Ben shu bao kuo shen jing shuai ruo gai shu, Shen jing shuai ruo zhi liao, Shen jing shuai ruo jia ting hu li, Shen jing shuai ruo kang fu, Shen jing shuai ruo yu fang deng

1 (p1): 第1章 行业内竞争:社会文化进化论 6 (p1-1): 组织种群的社会文化进化 7 (p1-2): 达尔文进化论和拉马克进化论 8 (p1-3): 变异 12 (p1-4): 选择性保留 18 (p1-5): r-K选择 23 (p1-6): r-K选择:影院行业 27 (p1-7): r-K选择:日报 37 (p2): 第2章 生态位理论 41 (p2-1): 竞争 43 (p2-2): 种群、群落、产业的概念 45 (p2-3): 空间:市场和群落 48 (p2-4): 资源维度 49 (p2-4-1): 满足 52 (p2-4-2): 满足机会 54 (p2-4-3): 时间支出和广告投放 56 (p2-4-4): 宏观维度和微观维度 57 (p2-5): 资源可用性:生态位宏观维度的关系 59 (p2-6): 资源限制 60 (p2-7): 媒体内容作为生态位维度 61 (p2-8): 生态位宽度和生态位重叠 65 (p2-9): 竞争优势 67 (p2-10): 竞争置换 68 (p2-11): 生态位分析的层次 70 (p2-12): 生态位和媒体竞争 73 (p3): 第3章 广告竞争 73 (p3-1): 报纸与广告公司 77 (p3-2): 广告媒体的可替代性 79 (p3-3): 广播的崛起 85 (p3-4): 电视对广播的置换 97 (p3-5): 电视对杂志的影响 99 (p3-6): 有线电视问世 103 (p3-7): 广告同资源种团:专业与综合并存 109 (p4): 第4章 生态位和战略集团:生态位宽度战略 110 (p4-1): 生态位和战略集团 114 (p4-2): 生态位宽度策略 118 (p4-3): 规模 118 (p4-4): 多元化 123 (p4-5): 范围经济 125 (p4-6): 跨部门合作 127 (p4-7): 生态位宽度策略 129 (p4-8): 跨行业集中 133 (p5): 第5章 满足-效用生态位 134 (p5-1): 环境与生态位 135 (p5-2): 满足-效用生态位:生态位宽度、重叠和优势的计算 140 (p5-3): 日常新闻媒体:报纸,广播和有线电视 150 (p5-4): 视频娱乐媒体 155 (p5-5): “视频革命”,相对常数原理,满足-效用以及电视媒体产业结构 160 (p5-6): 互联网 161 (p5-6-1): 互动领域:电子邮件 168 (p5-6-2): 互联网新闻 175 (p5-7): 结论:“满足机会”的重要性 177 (p6): 第6章 传媒竞争与共存的其他方面 178 (p6-1): 媒体内容生态位维度 178 (p6-1-1): 生态位宽度和媒体内容多样性 180 (p6-1-2): 生态位重叠:衡量媒体竞争的一个指标 191 (p6-1-3): 媒体内容生态位计算:一项说明性研究 194 (p6-2): 媒体的系列竞争 199 (p7): 第7章 群落层次的生态位差异、媒体共存和其他问题 200 (p7-1): 广告优势度下降 205 (p7-2): 媒体消费价格的差异 207 (p7-3): 媒体共存与复杂性 210 (p7-4): 未来的研究 213 (p8): 译后记 本书研究了在激烈的市场竞争中, 媒体公司及整个行业如何生生不息地延续下去的问题.作者在生态位理论研究中也融入了常规经济学理论

1 (p0-1): .药物治疗(35) 1 (p0-2): .劳逸结合(205) 1 (p0-3): 目录 1 (p0-4): .适度休息(135) 1 (p0-5): 神经衰弱的康复 1 (p0-6): .家属应如何对待神经衰弱患者(125) 1 (p0-7): 神经衰弱的家庭护理 1 (p0-8): 神经衰弱的预防 1 (p0-9): 神经衰弱的治疗 1 (p0-10): .神经衰弱青睐白领和脑力劳动者(3) 1 (p0-11): 神经衰弱概述 2 (p0-12): .减轻心理压力(207) 2 (p0-13): .服药注意事项(128) 2 (p0-14): .运动治疗(52) 2 (p0-15): .神经衰弱与性格有关(8) 2 (p0-16): .科学用脑(137) 3 (p0-17): .保持正常的睡眠和觉醒节律(210) 3 (p0-18): .如何定期到医院复查(130) 3 (p0-19): .神经衰弱产生的原因(11) 3 (p0-20): .保持良好的心态(141) 3 (p0-21): .饮食与药膳治疗(70) 4 (p0-22): .心理治疗(82) 4 (p0-23): .不要对生活有过高的要求(211) 4 (p0-24): .适当的体力劳动(148) 4 (p0-25): .饮食注意事项(130) 4 (p0-26): .神经衰弱的种种表现(16) 5 (p0-27): .如何才能提高心理素质(212) 5 (p0-28): .如何诊断神经衰弱(23) 5 (p0-29): .其他治疗(106) 5 (p0-30): .改变个性(150) 6 (p0-31): .合理安排自己的生活(151) 6 (p0-32): .扩展兴趣(214) 7 (p0-33): .建立良好的支持系统(152) 7 (p0-34): .保持良好的情绪(217) 8 (p0-35): .培养广泛的兴趣(153) 8 (p0-36): .增强适应能力(221) 9 (p0-37): .有规律的生活(223) 9 (p0-38): .烦恼的自我调节(154) 10 (p0-39): .加强体育锻炼 (224) 10 (p0-40): .疲劳感的自我调节(155) 11 (p0-41): .加强营养(227) 11 (p0-42): .失眠的自我调节(158) 12 (p0-43): .各种不同的冥想方式(165) 12 (p0-44): .普及医学心理卫生知识(230) 13 (p0-45): .呼吸调节(168) 14 (p0-46): .饮用红茶(171) 15 (p0-47): .压力的自我调节(173) 16 (p0-48): .紧张状态的自我调节(182) 17 (p0-49): .静默疗法(184) 18 (p0-50): .想像调节(186) 19 (p0-51): .自我催眠(189) 20 (p0-52): .自体发生训练疗法(193) 21 (p0-53): .建立良好的人际关系(197) 22 (p0-54): .瑜伽松弛疗法(198) 23 (p0-55): .坐弹 (200) 24 (p0-56): .数学疗法(200) Ben shu bao kuo shen jing shuai ruo gai shu, Shen jing shuai ruo zhi liao, Shen jing shuai ruo jia ting hu li, Shen jing shuai ruo kang fu, Shen jing shuai ruo yu fang deng

Ben shu bao kuo shen jing shuai ruo gai shu, Shen jing shuai ruo zhi liao, Shen jing shuai ruo jia ting hu li, Shen jing shuai ruo kang fu, Shen jing shuai ruo yu fang deng

本书据1998年教育部颁布本科最新专业目录编写, 分有机高分子材料助剂, 无机非金属材料加工助剂两部分, 讲述了材料的增塑剂, 材料的增韧剂, 材料的增强剂等

本书据1998年教育部颁布本科最新专业目录编写, 分有机高分子材料助剂, 无机非金属材料加工助剂两部分, 讲述了材料的增塑剂, 材料的增韧剂, 材料的增强剂等

封面 1 书名 2 版权 3 前言 4 目录 10 1 13 2 14 3 15 4 16 5 17 6 18 7 19 8 20 9 21 10 22 11 23 12 24 13 25 14 26 15 27 16 28 17 29 18 30 19 31 20 32 21 33 22 34 23 35 24 36 25 37 26 38 27 39 28 40 29 41 30 42 31 43 32 44 33 45 34 46 35 47 36 48 37 49 38 50 39 51 40 52 41 53 42 54 43 55 44 56 45 57 46 58 47 59 48 60 49 61 50 62 51 63 52 64 53 65 54 66 55 67 56 68 57 69 58 70 59 71 60 72 61 73 62 74 63 75 64 76 65 77 66 78 67 79 68 80 69 81 70 82 71 83 72 84 73 85 74 86 75 87 76 88 77 89 78 90 79 91 80 92 81 93 82 94 83 95 84 96 85 97 86 98 87 99 88 100 89 101 90 102 91 103 92 104 93 105 94 106 95 107 96 108 97 109 98 110 99 111 100 112 101 113 102 114 103 115 104 116 105 117 106 118 107 119 108 120 109 121 110 122 111 123 112 124 113 125 114 126 115 127 116 128 117 129 118 130 119 131 120 132 121 133 122 134 123 135 124 136 125 137 126 138 127 139 128 140 129 141 130 142 131 143 132 144 133 145 134 146 135 147 136 148 137 149 138 150 139 151 140 152 141 153 142 154 143 155 144 156 145 157 146 158 147 159 148 160 149 161 150 162 151 163 152 164 153 165 154 166 155 167 156 168 157 169 158 170 159 171 160 172 161 173 162 174 163 175 164 176 165 177 166 178 167 179 168 180 169 181 170 182 171 183 172 184 173 185 174 186 175 187 176 188 177 189 178 190 179 191...

187p

Includes index

This new edition features research from nearly 60 of the profession's most distinguished international authorities. Recognizing emerging developments in biopolymer systems research with fully updated and expanded chapters, the second edition discusses the biopolymer-based multilayer structures and their application in biosensors, the progress made in the understanding of protein behaviour at the air-water interface, experimental findings in ellipsometry and reflectometry, and recent developments concerning protein interfacial behaviour in microfabricated total analysis systems and microarrays. With over 3000 references, this is an essential reference for professionals and students in surface, pharmaceutical, colloid, polymer, and medicinal chemistry; chemical, formulation, and application engineering; and pharmacy.

Biopolymers at Interfaces......Page 2 Preface......Page 8 Contents......Page 9 Contributors......Page 12 MACROMOLECULES ARE SOFT PARTICLES......Page 16 Table of Contents......Page 0 ADSORPTION AND PARTICLE DEFORMATION......Page 18 FORMATION OF AN ADSORBED LAYER......Page 19 THE HOMOGENEOUS LAYER IN EQUILIBRIUM......Page 20 ADSORPTION AND DESORPTION RATES......Page 23 STRUCTURE OF ADSORBED LAYERS......Page 24 POLYMER MIXTURES: PREFERENCE AND EXCHANGE......Page 25 SPREADING: EXPERIMENTAL EVIDENCE......Page 26 POLYELECTROLYTES AND POLYAMPHOLYTES......Page 29 REFERENCES......Page 33 INTRODUCTION......Page 36 TRENDS IN THE ADSORPTION BEHAVIOR OF UNCHARGED AND CHARGED FLEXIBLE POLYMERS......Page 37 STRUCTURE AND STABILITY OF GLOBULAR PROTEINS IN AQUEOUS SOLUTION......Page 40 Coulomb Interaction......Page 41 Lifshitz – van der Waals Interactions......Page 42 Bond Lengths and Bond Angles......Page 43 ADSORPTION OF PROTEINS FROM AQUEOUS SOLUTION ONTO SOLID SURFACES......Page 45 Redistribution of Charged Groups Resulting from Overlapping Electrical Double Layers......Page 46 Dispersion Interaction......Page 51 Hydration Changes......Page 52 Rearrangements in the Protein Structure......Page 53 CONCLUSIONS......Page 54 REFERENCES......Page 55 INTRODUCTION......Page 59 Dynamic Approach......Page 60 Amino Acids......Page 61 Linear Peptides......Page 70 Nucleic Acid Bases......Page 76 Nucleotides......Page 79 CONCLUSIONS AND FUTURE PROSPECTS......Page 82 REFERENCES......Page 83 INTRODUCTION......Page 85 Electrostatics......Page 88 van der Waals Interactions......Page 92 Solvation Forces......Page 95 RELATION TO BULK ADSORPTION MEASUREMENTS......Page 96 Protein – Surface Interactions......Page 97 Protein – Protein Interactions......Page 100 REFERENCES......Page 104 INTRODUCTION......Page 109 INTERFACIAL BEHAVIOR OF NATURALLY OCCURRING PROTEIN VARIANTS......Page 110 INTERFACIAL BEHAVIOR OF STABILITY MUTANTS......Page 111 INTERFACIAL BEHAVIOR OF INTERACTION MUTANTS......Page 116 INTERFACIAL BEHAVIOR OF ASSOCIATION MUTANTS......Page 124 ACKNOWLEDGMENTS......Page 125 REFERENCES......Page 126 INTRODUCTION......Page 128 Preparation of Antibodies and Their Fragments......Page 132 Chemical Modification of Antibodies and Their Fragments......Page 133 Immobilization of Antibodies......Page 137 Immunoassays......Page 140 Orientation of Immobilized Antibodies......Page 145 Activity of Immobilized Antibodies......Page 146 Packing and Orientation of Acid-Pretreated Antibodies Immobilized by Physical Adsorption......Page 162 Applications of Immobilized Antibodies......Page 168 CONCLUSIONS......Page 169 REFERENCES......Page 170 INTRODUCTION......Page 177 van der Waals Forces......Page 179 Electrostatic Double-Layer Forces......Page 181 Repulsive Short-Range Forces......Page 182 Hydrogen Bonds......Page 183 Interactions Due to Adsorbed Uncharged Polymer Layers......Page 184 METHODS......Page 185 Sugar-Based Surfactants......Page 188 Glycolipids......Page 192 Polysaccharides......Page 195 Glycoproteins......Page 201 SUMMARY......Page 204 REFERENCES......Page 205 INTRODUCTION — THE KINETIC IMPERATIVE......Page 210 FUNDAMENTAL CHARACTERISTICS OF AN ADSORPTION PROCESS......Page 211 EXPERIMENTAL PREREQUISITES......Page 215 Measuring the Rate of Accumulation......Page 216 Obtaining Complementary Information......Page 217 The Memory Function......Page 218 The Adsorption Rate Coefficient......Page 219 Transport Phenomena......Page 220 Exclusion Zones......Page 221 Postadsorption Changes and Desorption......Page 223 COLLECTIVE EFFECTS......Page 224 Adsorption to a Continuum......Page 225 Adsorption to Discrete Receptor Sites......Page 226 PERSPECTIVES......Page 227 LIST OF PRINCIPAL SYMBOLS......Page 228 REFERENCES......Page 229 INTRODUCTION......Page 232 Two-Dimensional Order......Page 233 Relevance to Experimentation: Effect of Protein Mobility on Scanning Probe Microscopy......Page 234 Basic Insight into Adsorbed Layer Heterogeneity......Page 235 INDIRECT EVIDENCE FOR ADSORBED PROTEIN MOBILITY......Page 236 Fluorescence Recovery After Photobleaching......Page 238 Other Techniques......Page 247 WHICH DIFFUSION COEFFICIENT IS MEASURED?......Page 248 DIRECT MEASUREMENTS OF SURFACE DIFFUSION......Page 250 Lateral Interactions: Effect of Coverage......Page 252 Origin of the Immobile Fraction......Page 255 SURFACE DIFFUSION MECHANISM......Page 257 Comparison of Adsorbed Proteins......Page 259 FUTURE RESEARCH......Page 263 REFERENCES......Page 264 INTRODUCTION......Page 269 Insulin......Page 271 b-Lactoglobulin......Page 281 ADSORPTION OF SELF-ASSOCIATING PROTEINS WITH UNORDERED STRUCTURE......Page 284 ADSORPTION IN RELATION TO (HEAT) AGGREGATION OF PROTEINS......Page 291 ACKNOWLEDGMENT......Page 296 REFERENCES......Page 297 INTRODUCTION......Page 305 EXPERIMENTAL TECHNIQUES FOR STUDIES OF COMPETITIVE AND SEQUENTIAL ADSORPTION REACTIONS......Page 307 STUDIES OF THE REACTION MECHANISM OF EXCHANGE: GENERAL RESULTS......Page 311 PERSPECTIVES AND CONCLUDING REMARKS......Page 320 REFERENCES......Page 323 GENERAL FEATURES OF THE INTERACTIONS BETWEEN PROTEINS AND SURFACTANTS AT SOLID INTERFACES......Page 331 Removal of Proteins from Solid Interfaces by Surfactants......Page 332 Competitive Adsorption of Proteins and Surfactants......Page 334 Surfactant......Page 335 Protein......Page 339 Surface......Page 341 Cleaning Food Processing Equipment......Page 344 Dental Applications......Page 345 Biochemical Applications......Page 346 CONCLUDING REMARKS......Page 347 REFERENCES......Page 348 INTRODUCTION......Page 354 Interactions of Proteins and Polyelectrolytes in Solution......Page 356 Adsorption of Proteins on Polyelectrolyte Multilayers......Page 357 Structure of Proteins Adsorbed on or Embedded in Polyelectrolyte Multilayers......Page 360 Diffusion of Proteins on and in Polyelectrolyte Multilayers......Page 362 Construction of Polyelectrolyte Multilayers with Natural Polyelectrolytes......Page 363 Interaction of Polyelectrolyte Multilayers with Cells......Page 365 BIOMINERALIZATION INDUCTION BY POLYELECTROLYTE MULTILAYER FILMS......Page 370 REFERENCES......Page 372 INTRODUCTION: ALTERNATE LAYER-BY-LAYER ADSORPTION AS A NOVEL METHODOLOGY FOR PROTEIN ORGANIZATION......Page 376 PRACTICAL PROCEDURE AND ADVANTAGES......Page 378 EVALUATION OF ASSEMBLING PROCESS......Page 380 PLANAR FILM – TYPE ENZYME NANOREACTOR......Page 385 PROTEIN ASSEMBLY ON MICROTEMPLATE......Page 390 ENZYME-CONTAINING POLYION CAPSULE......Page 394 FUTURE PERSPECTIVE......Page 396 REFERENCES......Page 397 BIOCHEMICAL BASIS OF THE BIOLOGICAL ACTIVITY OF ADSORBED PROTEINS......Page 401 Affinity of the Adhesion Proteins......Page 403 Types of Nonfouling Materials......Page 404 Poly(Ethylene Oxide) – Like Nonfouling Materials......Page 405 Antibody Binding Studies......Page 410 Cell Interactions......Page 413 REFERENCES......Page 416 Model Membranes......Page 422 Monolayer Characterization: Surface Pressure and Surface Potential......Page 424 Protein Interfacial Activity and Surface Tension......Page 425 Light Reflection at the Air – Water Interface......Page 426 Electrostatic Binding of Proteins to Monolayers......Page 427 Amphiphile Miscibility, Phases, and Protein Adsorption......Page 428 Enhanced Protein Adsorption to Mixed Monolayers: Ferritin Binding to Mixed Cationic/Neutral Monolayers......Page 429 Amphiphile Miscibility and Mixing Diagrams......Page 431 PEO Surface Density Versus PEO Brush Length......Page 434 In Situ SPR Measurements of PS-PEO Monolayer Protein Interactions......Page 436 Protein – PS-PEO Monolayer Interactions Sensed by the Surface Pressure Changes......Page 438 REFERENCES......Page 439 Interaction of Protein Molecules with Light......Page 442 Surface Versus Bulk Sensitivity......Page 443 Proteins’ Private and Public Lives......Page 446 Local Versus Global Spectroscopic Probes of Protein Structure and Dynamics......Page 447 Protein Fluorescence......Page 449 Total Internal Reflection Fluorescence Spectroscopy......Page 452 INFRARED SPECTROSCOPY AND CIRCULAR DICHROISM AS GLOBAL PROBES OF PROTEIN MOLECULES......Page 458 Infrared Spectroscopy......Page 459 Analysis of Protein Conformation from IR Spectra......Page 462 Circular Dichroism......Page 464 REMAINING PROBLEMS AND FUTURE OUTLOOK......Page 466 REFERENCES......Page 467 INTRODUCTION......Page 474 Sampling Modes......Page 475 Basics of Attenuated Total Internal Reflection......Page 476 Quantification of Adsorbed Proteins......Page 477 CAN H2O BE SUBTRACTED FROM PROTEIN SPECTRA?......Page 480 Relationship to X-Ray Crystallography......Page 483 Quantitation of Secondary Structure......Page 484 FTIR and Blood Proteins......Page 485 FTIR and Orientation......Page 486 FTIR AND MULTIPLE PROTEIN SOLUTIONS......Page 487 ATOMIC FORCE MICROSCOPY AND SURFACES......Page 488 SURFACE MODIFICATION STRATEGIES......Page 490 Self-Assembled Monolayers for Surface Modification......Page 491 SAMs in Biomaterials Research......Page 492 RGD Peptides on Surfaces......Page 493 CONCLUSIONS......Page 495 REFERENCES......Page 496 CONFORMATIONAL CHANGES OF PROTEINS AT SOLID SURFACES......Page 504 THE MOLTEN GLOBULE STATE......Page 505 Bovine Serum Albumin......Page 506 Human Carbonic Anhydrase II......Page 507 Circular Dichroism......Page 508 Fluorescence......Page 509 CONFORMATIONAL CHANGES OF STABILITY MUTANTS OF BACTERIOPHAGE T4 LYSOZYME ADSORBED ONTO COLLOIDAL SILICA PARTICLES......Page 510 TRUNCATED VARIANTS OF HCAII ADSORBED TO NANOPARTICLES OBTAIN A MOLTEN GLOBULE-LIKE STATE......Page 513 ACKNOWLEDGMENTS......Page 518 REFERENCES......Page 519 INTRODUCTION — PROTEINS AT INTERFACES......Page 523 TRANSITION ENTHALPIES AS STABILITY CHARACTERISTICS......Page 524 THE DSC MEASUREMENT OF PROTEINS IN SOLUTION......Page 525 HEAT CAPACITY INCREASES DUE TO THE INCREASE IN HYDROPHOBICITY DURING DENATURATION......Page 528 PROTEINS AT INTERFACES AS SEEN BY DSC......Page 530 Substrate Effects on Conformation......Page 531 Interaction with Separation Matrices......Page 533 Stabilization Through Formation of Solid Phase Affinity Complexes......Page 536 Antibodies as Affinity Anchors......Page 538 Direct Adsorption versus Tethered Attachment......Page 539 ACKNOWLEDGMENTS......Page 541 REFERENCES......Page 542 METHODOLOGY......Page 545 Ellipsometry......Page 546 Reflectometry......Page 549 Surfaces......Page 551 Surface Modifications......Page 555 Comparison with Other Methods......Page 559 Multilayers......Page 561 Examples of Adsorbed Layer Structure in Biopolymer Systems......Page 562 INVESTIGATIONS OF OPTICAL PROPERTIES OF ADSORBED PROTEINS......Page 564 Mass Transport......Page 565 Affinity Measurements......Page 566 Adsorbed Layer Formation......Page 567 Multicomponent Systems......Page 571 Interfacial Degradation and Synthesis......Page 577 REFERENCES......Page 580 INTRODUCTION......Page 589 SURFACE PLASMON SPECTROSCOPY AND SURFACE PLASMON FIELD-ENHANCED FLUORESCENCE SPECTROSCOPY......Page 590 Monitoring Protein Adsorption/Desorption Processes by SPR......Page 591 Simultaneous SPR and SPFS Studies......Page 593 MINIMIZING NONSPECIFIC ADSORPTION TO POLYMER-MODIFIED SURFACES......Page 595 SURFACE RECONSTITUTION OF CYTOCHROME b562......Page 599 INTERACTION OF SINGLE STRAND BINDING PROTEINS WITH SURFACE-ATTACHED OLIGONUCLEOTIDES......Page 602 RECOGNITION OF STEROL MOLECULES IN TETHERED MEMBRANES......Page 607 CONCLUSIONS AND OUTLOOK......Page 611 REFERENCES......Page 612 INTRODUCTION......Page 614 NEUTRON REFLECTION AND DATA ANALYSIS......Page 615 EXCHANGE OF LABILE HYDROGENS......Page 617 ADSORPTION AT THE HYDROPHILIC SILICON OXIDE – WATER INTERFACE......Page 621 ADSORPTION AT THE HYDROPHOBIC SOLID – WATER INTERFACE......Page 626 ADSORPTION AT THE C15OH – WATER INTERFACE......Page 631 ADSORPTION AT THE PC MONOLAYER – SOLUTION INTERFACE......Page 639 SUMMARY......Page 642 REFERENCES......Page 644 INTRODUCTION......Page 646 General Considerations......Page 648 Characterization of Protein Adsorption......Page 649 Limitations of the Technique......Page 653 General Considerations......Page 654 Static ToF-SIMS Analysis of Peptides and Proteins......Page 655 Challenges and Advances in Static ToF-SIMS Analysis of Proteins......Page 656 Static ToF-SIMS Chemical State Imaging......Page 659 Emerging Technologies and Applications......Page 660 General Considerations......Page 661 Characterization of Adsorbed Protein Films......Page 663 Study of Competitive Protein Adsorption and Displacement......Page 666 Present Limitations......Page 667 CONCLUSIONS......Page 669 REFERENCES......Page 670 Synthetic Membranes and Biotechnology......Page 675 Analyzing the Problem......Page 677 Overview of Phenomena......Page 678 Protein Adsorption......Page 679 Protein Deposition......Page 685 Properties of Protein Deposits......Page 690 Protein – Protein Interactions......Page 692 Biological Molecule Interactions (Nonproteins)......Page 693 Protein – Polymer Interactions......Page 694 Control of Solution Conditions......Page 700 Use of Surface Modification Techniques......Page 701 REFERENCES......Page 707 INTRODUCTION......Page 714 Micelles......Page 715 Liposomes......Page 716 Others......Page 717 Methodology......Page 718 Effects of Wettability......Page 719 Effects of Charge......Page 720 Mixed Phospholipid Systems......Page 722 Effects of Lipid Fluidity......Page 723 Adsorption from Serum and Plasma......Page 724 Complement Activation......Page 725 Controlled Circulation Time and Tissue Distribution Through Use of PEG-Containing Carriers......Page 726 Mechanisms of Protein Rejection......Page 727 Different Types of PEG Modification......Page 729 Effects of Chain Length......Page 730 Effects of Chain Density......Page 731 Effects of Anchoring......Page 733 Mechanisms and Effects of Solvency......Page 734 CONCLUDING REMARKS......Page 735 REFERENCES......Page 736 INTRODUCTION......Page 743 PRINCIPLES OF SOLID-PHASE DIAGNOSTICS......Page 744 PRINCIPLES OF THERAPEUTIC APHERESIS......Page 745 Protein Adsorption......Page 747 Poly(Ethylene Glycol) – Grafted Surfaces......Page 748 Immobilization of Proteins to Poly(Ethylene Glycol) – Grafted Surfaces......Page 758 Site-Specific Immobilization......Page 761 SOLID-PHASE DIAGNOSTICS ON HYDROPHILIZED PLATES......Page 762 NONSPECIFIC THERAPEUTIC APHERESIS: REMOVAL OF LOW-MOLECULAR-WEIGHT PROTEINS......Page 764 SPECIFIC THERAPEUTIC APHERESIS: REMOVAL OF HIGH-MOLECULAR-WEIGHT PROTEINS ON HYDROPHILIZED CARTRIDGES......Page 765 Removal of Antibodies of a Defined Specificity......Page 766 CONCLUSIONS......Page 768 REFERENCES......Page 769 INTRODUCTION......Page 774 Surface Area – to – Bulk Volume Ratio......Page 775 Diffusion Length......Page 777 Electroosmotic Flow......Page 778 Other Methods for Fluid Control......Page 781 SEPARATION OF PROTEINS USING CAPILLARY ELECTROPHORESIS......Page 782 IMMUNOASSAYS......Page 784 Tryptic Digestion......Page 793 MICROARRAYS......Page 798 CONCLUSIONS......Page 804 REFERENCES......Page 805 INTRODUCTION......Page 812 SALIVARY PROTEINS......Page 813 Globular......Page 815 Flexible......Page 816 Protein Association Phenomena and Structure Formation in Saliva......Page 818 ORAL INTERFACES......Page 819 PELLICLE......Page 821 Adsorption from Salivary Solutions — Physicochemical Properties......Page 823 Behavior of Isolated Protein Fractions......Page 831 Aspects of Composition and Development......Page 835 PLAQUE FORMATION......Page 838 ROUTES FOR MODULATION OF PLAQUE GROWTH......Page 841 SALIVARY SUBSTITUTES......Page 843 REFERENCES......Page 844 INTRODUCTION......Page 857 b-Casein......Page 859 Adsorbed b-Lactoglobulin......Page 865 Surface Studies......Page 866 KINETICS OF ADSORPTION OF PROTEINS AT FLUID INTERFACES......Page 867 Protein Adsorption at the Oil – Water Interface......Page 869 Protein Adsorption at the Air – Water Interface......Page 872 Adsorbed Protein Films at the Oil – Water Interface......Page 875 Adsorbed and Spread Protein Films at the Air – Water Interface......Page 876 Long-Term Relaxation Phenomena of Spread Protein Films at the Air – Water Interface......Page 878 Surface Dilatational Characteristics of Spread Protein Films at the Air – Water Interface......Page 880 GELATION OF ADSORBED PROTEIN FILMS AT THE OIL – WATER INTERFACE......Page 882 Interactions Between Protein-Coated Surfaces......Page 884 Comparison of as1-Casein and b-Casein Behavior......Page 885 COMPETITIVE DISPLACEMENT......Page 886 Physical Methods......Page 887 Competitive Adsorption and Displacement in Protein – Lipid Mixed Systems......Page 889 CONCLUDING REMARKS......Page 894 REFERENCES......Page 895

Biopolymers at Interfaces......Page 2 Preface......Page 8 Contents......Page 9 Contributors......Page 12 MACROMOLECULES ARE SOFT PARTICLES......Page 16 Table of Contents......Page 0 ADSORPTION AND PARTICLE DEFORMATION......Page 18 FORMATION OF AN ADSORBED LAYER......Page 19 THE HOMOGENEOUS LAYER IN EQUILIBRIUM......Page 20 ADSORPTION AND DESORPTION RATES......Page 23 STRUCTURE OF ADSORBED LAYERS......Page 24 POLYMER MIXTURES: PREFERENCE AND EXCHANGE......Page 25 SPREADING: EXPERIMENTAL EVIDENCE......Page 26 POLYELECTROLYTES AND POLYAMPHOLYTES......Page 29 REFERENCES......Page 33 INTRODUCTION......Page 36 TRENDS IN THE ADSORPTION BEHAVIOR OF UNCHARGED AND CHARGED FLEXIBLE POLYMERS......Page 37 STRUCTURE AND STABILITY OF GLOBULAR PROTEINS IN AQUEOUS SOLUTION......Page 40 Coulomb Interaction......Page 41 Lifshitz – van der Waals Interactions......Page 42 Bond Lengths and Bond Angles......Page 43 ADSORPTION OF PROTEINS FROM AQUEOUS SOLUTION ONTO SOLID SURFACES......Page 45 Redistribution of Charged Groups Resulting from Overlapping Electrical Double Layers......Page 46 Dispersion Interaction......Page 51 Hydration Changes......Page 52 Rearrangements in the Protein Structure......Page 53 CONCLUSIONS......Page 54 REFERENCES......Page 55 INTRODUCTION......Page 59 Dynamic Approach......Page 60 Amino Acids......Page 61 Linear Peptides......Page 70 Nucleic Acid Bases......Page 76 Nucleotides......Page 79 CONCLUSIONS AND FUTURE PROSPECTS......Page 82 REFERENCES......Page 83 INTRODUCTION......Page 85 Electrostatics......Page 88 van der Waals Interactions......Page 92 Solvation Forces......Page 95 RELATION TO BULK ADSORPTION MEASUREMENTS......Page 96 Protein – Surface Interactions......Page 97 Protein – Protein Interactions......Page 100 REFERENCES......Page 104 INTRODUCTION......Page 109 INTERFACIAL BEHAVIOR OF NATURALLY OCCURRING PROTEIN VARIANTS......Page 110 INTERFACIAL BEHAVIOR OF STABILITY MUTANTS......Page 111 INTERFACIAL BEHAVIOR OF INTERACTION MUTANTS......Page 116 INTERFACIAL BEHAVIOR OF ASSOCIATION MUTANTS......Page 124 ACKNOWLEDGMENTS......Page 125 REFERENCES......Page 126 INTRODUCTION......Page 128 Preparation of Antibodies and Their Fragments......Page 132 Chemical Modification of Antibodies and Their Fragments......Page 133 Immobilization of Antibodies......Page 137 Immunoassays......Page 140 Orientation of Immobilized Antibodies......Page 145 Activity of Immobilized Antibodies......Page 146 Packing and Orientation of Acid-Pretreated Antibodies Immobilized by Physical Adsorption......Page 162 Applications of Immobilized Antibodies......Page 168 CONCLUSIONS......Page 169 REFERENCES......Page 170 INTRODUCTION......Page 177 van der Waals Forces......Page 179 Electrostatic Double-Layer Forces......Page 181 Repulsive Short-Range Forces......Page 182 Hydrogen Bonds......Page 183 Interactions Due to Adsorbed Uncharged Polymer Layers......Page 184 METHODS......Page 185 Sugar-Based Surfactants......Page 188 Glycolipids......Page 192 Polysaccharides......Page 195 Glycoproteins......Page 201 SUMMARY......Page 204 REFERENCES......Page 205 INTRODUCTION — THE KINETIC IMPERATIVE......Page 210 FUNDAMENTAL CHARACTERISTICS OF AN ADSORPTION PROCESS......Page 211 EXPERIMENTAL PREREQUISITES......Page 215 Measuring the Rate of Accumulation......Page 216 Obtaining Complementary Information......Page 217 The Memory Function......Page 218 The Adsorption Rate Coefficient......Page 219 Transport Phenomena......Page 220 Exclusion Zones......Page 221 Postadsorption Changes and Desorption......Page 223 COLLECTIVE EFFECTS......Page 224 Adsorption to a Continuum......Page 225 Adsorption to Discrete Receptor Sites......Page 226 PERSPECTIVES......Page 227 LIST OF PRINCIPAL SYMBOLS......Page 228 REFERENCES......Page 229 INTRODUCTION......Page 232 Two-Dimensional Order......Page 233 Relevance to Experimentation: Effect of Protein Mobility on Scanning Probe Microscopy......Page 234 Basic Insight into Adsorbed Layer Heterogeneity......Page 235 INDIRECT EVIDENCE FOR ADSORBED PROTEIN MOBILITY......Page 236 Fluorescence Recovery After Photobleaching......Page 238 Other Techniques......Page 247 WHICH DIFFUSION COEFFICIENT IS MEASURED?......Page 248 DIRECT MEASUREMENTS OF SURFACE DIFFUSION......Page 250 Lateral Interactions: Effect of Coverage......Page 252 Origin of the Immobile Fraction......Page 255 SURFACE DIFFUSION MECHANISM......Page 257 Comparison of Adsorbed Proteins......Page 259 FUTURE RESEARCH......Page 263 REFERENCES......Page 264 INTRODUCTION......Page 269 Insulin......Page 271 b-Lactoglobulin......Page 281 ADSORPTION OF SELF-ASSOCIATING PROTEINS WITH UNORDERED STRUCTURE......Page 284 ADSORPTION IN RELATION TO (HEAT) AGGREGATION OF PROTEINS......Page 291 ACKNOWLEDGMENT......Page 296 REFERENCES......Page 297 INTRODUCTION......Page 305 EXPERIMENTAL TECHNIQUES FOR STUDIES OF COMPETITIVE AND SEQUENTIAL ADSORPTION REACTIONS......Page 307 STUDIES OF THE REACTION MECHANISM OF EXCHANGE: GENERAL RESULTS......Page 311 PERSPECTIVES AND CONCLUDING REMARKS......Page 320 REFERENCES......Page 323 GENERAL FEATURES OF THE INTERACTIONS BETWEEN PROTEINS AND SURFACTANTS AT SOLID INTERFACES......Page 331 Removal of Proteins from Solid Interfaces by Surfactants......Page 332 Competitive Adsorption of Proteins and Surfactants......Page 334 Surfactant......Page 335 Protein......Page 339 Surface......Page 341 Cleaning Food Processing Equipment......Page 344 Dental Applications......Page 345 Biochemical Applications......Page 346 CONCLUDING REMARKS......Page 347 REFERENCES......Page 348 INTRODUCTION......Page 354 Interactions of Proteins and Polyelectrolytes in Solution......Page 356 Adsorption of Proteins on Polyelectrolyte Multilayers......Page 357 Structure of Proteins Adsorbed on or Embedded in Polyelectrolyte Multilayers......Page 360 Diffusion of Proteins on and in Polyelectrolyte Multilayers......Page 362 Construction of Polyelectrolyte Multilayers with Natural Polyelectrolytes......Page 363 Interaction of Polyelectrolyte Multilayers with Cells......Page 365 BIOMINERALIZATION INDUCTION BY POLYELECTROLYTE MULTILAYER FILMS......Page 370 REFERENCES......Page 372 INTRODUCTION: ALTERNATE LAYER-BY-LAYER ADSORPTION AS A NOVEL METHODOLOGY FOR PROTEIN ORGANIZATION......Page 376 PRACTICAL PROCEDURE AND ADVANTAGES......Page 378 EVALUATION OF ASSEMBLING PROCESS......Page 380 PLANAR FILM – TYPE ENZYME NANOREACTOR......Page 385 PROTEIN ASSEMBLY ON MICROTEMPLATE......Page 390 ENZYME-CONTAINING POLYION CAPSULE......Page 394 FUTURE PERSPECTIVE......Page 396 REFERENCES......Page 397 BIOCHEMICAL BASIS OF THE BIOLOGICAL ACTIVITY OF ADSORBED PROTEINS......Page 401 Affinity of the Adhesion Proteins......Page 403 Types of Nonfouling Materials......Page 404 Poly(Ethylene Oxide) – Like Nonfouling Materials......Page 405 Antibody Binding Studies......Page 410 Cell Interactions......Page 413 REFERENCES......Page 416 Model Membranes......Page 422 Monolayer Characterization: Surface Pressure and Surface Potential......Page 424 Protein Interfacial Activity and Surface Tension......Page 425 Light Reflection at the Air – Water Interface......Page 426 Electrostatic Binding of Proteins to Monolayers......Page 427 Amphiphile Miscibility, Phases, and Protein Adsorption......Page 428 Enhanced Protein Adsorption to Mixed Monolayers: Ferritin Binding to Mixed Cationic/Neutral Monolayers......Page 429 Amphiphile Miscibility and Mixing Diagrams......Page 431 PEO Surface Density Versus PEO Brush Length......Page 434 In Situ SPR Measurements of PS-PEO Monolayer Protein Interactions......Page 436 Protein – PS-PEO Monolayer Interactions Sensed by the Surface Pressure Changes......Page 438 REFERENCES......Page 439 Interaction of Protein Molecules with Light......Page 442 Surface Versus Bulk Sensitivity......Page 443 Proteins’ Private and Public Lives......Page 446 Local Versus Global Spectroscopic Probes of Protein Structure and Dynamics......Page 447 Protein Fluorescence......Page 449 Total Internal Reflection Fluorescence Spectroscopy......Page 452 INFRARED SPECTROSCOPY AND CIRCULAR DICHROISM AS GLOBAL PROBES OF PROTEIN MOLECULES......Page 458 Infrared Spectroscopy......Page 459 Analysis of Protein Conformation from IR Spectra......Page 462 Circular Dichroism......Page 464 REMAINING PROBLEMS AND FUTURE OUTLOOK......Page 466 REFERENCES......Page 467 INTRODUCTION......Page 474 Sampling Modes......Page 475 Basics of Attenuated Total Internal Reflection......Page 476 Quantification of Adsorbed Proteins......Page 477 CAN H2O BE SUBTRACTED FROM PROTEIN SPECTRA?......Page 480 Relationship to X-Ray Crystallography......Page 483 Quantitation of Secondary Structure......Page 484 FTIR and Blood Proteins......Page 485 FTIR and Orientation......Page 486 FTIR AND MULTIPLE PROTEIN SOLUTIONS......Page 487 ATOMIC FORCE MICROSCOPY AND SURFACES......Page 488 SURFACE MODIFICATION STRATEGIES......Page 490 Self-Assembled Monolayers for Surface Modification......Page 491 SAMs in Biomaterials Research......Page 492 RGD Peptides on Surfaces......Page 493 CONCLUSIONS......Page 495 REFERENCES......Page 496 CONFORMATIONAL CHANGES OF PROTEINS AT SOLID SURFACES......Page 504 THE MOLTEN GLOBULE STATE......Page 505 Bovine Serum Albumin......Page 506 Human Carbonic Anhydrase II......Page 507 Circular Dichroism......Page 508 Fluorescence......Page 509 CONFORMATIONAL CHANGES OF STABILITY MUTANTS OF BACTERIOPHAGE T4 LYSOZYME ADSORBED ONTO COLLOIDAL SILICA PARTICLES......Page 510 TRUNCATED VARIANTS OF HCAII ADSORBED TO NANOPARTICLES OBTAIN A MOLTEN GLOBULE-LIKE STATE......Page 513 ACKNOWLEDGMENTS......Page 518 REFERENCES......Page 519 INTRODUCTION — PROTEINS AT INTERFACES......Page 523 TRANSITION ENTHALPIES AS STABILITY CHARACTERISTICS......Page 524 THE DSC MEASUREMENT OF PROTEINS IN SOLUTION......Page 525 HEAT CAPACITY INCREASES DUE TO THE INCREASE IN HYDROPHOBICITY DURING DENATURATION......Page 528 PROTEINS AT INTERFACES AS SEEN BY DSC......Page 530 Substrate Effects on Conformation......Page 531 Interaction with Separation Matrices......Page 533 Stabilization Through Formation of Solid Phase Affinity Complexes......Page 536 Antibodies as Affinity Anchors......Page 538 Direct Adsorption versus Tethered Attachment......Page 539 ACKNOWLEDGMENTS......Page 541 REFERENCES......Page 542 METHODOLOGY......Page 545 Ellipsometry......Page 546 Reflectometry......Page 549 Surfaces......Page 551 Surface Modifications......Page 555 Comparison with Other Methods......Page 559 Multilayers......Page 561 Examples of Adsorbed Layer Structure in Biopolymer Systems......Page 562 INVESTIGATIONS OF OPTICAL PROPERTIES OF ADSORBED PROTEINS......Page 564 Mass Transport......Page 565 Affinity Measurements......Page 566 Adsorbed Layer Formation......Page 567 Multicomponent Systems......Page 571 Interfacial Degradation and Synthesis......Page 577 REFERENCES......Page 580 INTRODUCTION......Page 589 SURFACE PLASMON SPECTROSCOPY AND SURFACE PLASMON FIELD-ENHANCED FLUORESCENCE SPECTROSCOPY......Page 590 Monitoring Protein Adsorption/Desorption Processes by SPR......Page 591 Simultaneous SPR and SPFS Studies......Page 593 MINIMIZING NONSPECIFIC ADSORPTION TO POLYMER-MODIFIED SURFACES......Page 595 SURFACE RECONSTITUTION OF CYTOCHROME b562......Page 599 INTERACTION OF SINGLE STRAND BINDING PROTEINS WITH SURFACE-ATTACHED OLIGONUCLEOTIDES......Page 602 RECOGNITION OF STEROL MOLECULES IN TETHERED MEMBRANES......Page 607 CONCLUSIONS AND OUTLOOK......Page 611 REFERENCES......Page 612 INTRODUCTION......Page 614 NEUTRON REFLECTION AND DATA ANALYSIS......Page 615 EXCHANGE OF LABILE HYDROGENS......Page 617 ADSORPTION AT THE HYDROPHILIC SILICON OXIDE – WATER INTERFACE......Page 621 ADSORPTION AT THE HYDROPHOBIC SOLID – WATER INTERFACE......Page 626 ADSORPTION AT THE C15OH – WATER INTERFACE......Page 631 ADSORPTION AT THE PC MONOLAYER – SOLUTION INTERFACE......Page 639 SUMMARY......Page 642 REFERENCES......Page 644 INTRODUCTION......Page 646 General Considerations......Page 648 Characterization of Protein Adsorption......Page 649 Limitations of the Technique......Page 653 General Considerations......Page 654 Static ToF-SIMS Analysis of Peptides and Proteins......Page 655 Challenges and Advances in Static ToF-SIMS Analysis of Proteins......Page 656 Static ToF-SIMS Chemical State Imaging......Page 659 Emerging Technologies and Applications......Page 660 General Considerations......Page 661 Characterization of Adsorbed Protein Films......Page 663 Study of Competitive Protein Adsorption and Displacement......Page 666 Present Limitations......Page 667 CONCLUSIONS......Page 669 REFERENCES......Page 670 Synthetic Membranes and Biotechnology......Page 675 Analyzing the Problem......Page 677 Overview of Phenomena......Page 678 Protein Adsorption......Page 679 Protein Deposition......Page 685 Properties of Protein Deposits......Page 690 Protein – Protein Interactions......Page 692 Biological Molecule Interactions (Nonproteins)......Page 693 Protein – Polymer Interactions......Page 694 Control of Solution Conditions......Page 700 Use of Surface Modification Techniques......Page 701 REFERENCES......Page 707 INTRODUCTION......Page 714 Micelles......Page 715 Liposomes......Page 716 Others......Page 717 Methodology......Page 718 Effects of Wettability......Page 719 Effects of Charge......Page 720 Mixed Phospholipid Systems......Page 722 Effects of Lipid Fluidity......Page 723 Adsorption from Serum and Plasma......Page 724 Complement Activation......Page 725 Controlled Circulation Time and Tissue Distribution Through Use of PEG-Containing Carriers......Page 726 Mechanisms of Protein Rejection......Page 727 Different Types of PEG Modification......Page 729 Effects of Chain Length......Page 730 Effects of Chain Density......Page 731 Effects of Anchoring......Page 733 Mechanisms and Effects of Solvency......Page 734 CONCLUDING REMARKS......Page 735 REFERENCES......Page 736 INTRODUCTION......Page 743 PRINCIPLES OF SOLID-PHASE DIAGNOSTICS......Page 744 PRINCIPLES OF THERAPEUTIC APHERESIS......Page 745 Protein Adsorption......Page 747 Poly(Ethylene Glycol) – Grafted Surfaces......Page 748 Immobilization of Proteins to Poly(Ethylene Glycol) – Grafted Surfaces......Page 758 Site-Specific Immobilization......Page 761 SOLID-PHASE DIAGNOSTICS ON HYDROPHILIZED PLATES......Page 762 NONSPECIFIC THERAPEUTIC APHERESIS: REMOVAL OF LOW-MOLECULAR-WEIGHT PROTEINS......Page 764 SPECIFIC THERAPEUTIC APHERESIS: REMOVAL OF HIGH-MOLECULAR-WEIGHT PROTEINS ON HYDROPHILIZED CARTRIDGES......Page 765 Removal of Antibodies of a Defined Specificity......Page 766 CONCLUSIONS......Page 768 REFERENCES......Page 769 INTRODUCTION......Page 774 Surface Area – to – Bulk Volume Ratio......Page 775 Diffusion Length......Page 777 Electroosmotic Flow......Page 778 Other Methods for Fluid Control......Page 781 SEPARATION OF PROTEINS USING CAPILLARY ELECTROPHORESIS......Page 782 IMMUNOASSAYS......Page 784 Tryptic Digestion......Page 793 MICROARRAYS......Page 798 CONCLUSIONS......Page 804 REFERENCES......Page 805 INTRODUCTION......Page 812 SALIVARY PROTEINS......Page 813 Globular......Page 815 Flexible......Page 816 Protein Association Phenomena and Structure Formation in Saliva......Page 818 ORAL INTERFACES......Page 819 PELLICLE......Page 821 Adsorption from Salivary Solutions — Physicochemical Properties......Page 823 Behavior of Isolated Protein Fractions......Page 831 Aspects of Composition and Development......Page 835 PLAQUE FORMATION......Page 838 ROUTES FOR MODULATION OF PLAQUE GROWTH......Page 841 SALIVARY SUBSTITUTES......Page 843 REFERENCES......Page 844 INTRODUCTION......Page 857 b-Casein......Page 859 Adsorbed b-Lactoglobulin......Page 865 Surface Studies......Page 866 KINETICS OF ADSORPTION OF PROTEINS AT FLUID INTERFACES......Page 867 Protein Adsorption at the Oil – Water Interface......Page 869 Protein Adsorption at the Air – Water Interface......Page 872 Adsorbed Protein Films at the Oil – Water Interface......Page 875 Adsorbed and Spread Protein Films at the Air – Water Interface......Page 876 Long-Term Relaxation Phenomena of Spread Protein Films at the Air – Water Interface......Page 878 Surface Dilatational Characteristics of Spread Protein Films at the Air – Water Interface......Page 880 GELATION OF ADSORBED PROTEIN FILMS AT THE OIL – WATER INTERFACE......Page 882 Interactions Between Protein-Coated Surfaces......Page 884 Comparison of as1-Casein and b-Casein Behavior......Page 885 COMPETITIVE DISPLACEMENT......Page 886 Physical Methods......Page 887 Competitive Adsorption and Displacement in Protein – Lipid Mixed Systems......Page 889 CONCLUDING REMARKS......Page 894 REFERENCES......Page 895

With his own literary production and his literary scholarship and criticism, Ludwig Tieck (1773‐1853) was a determining figure in literature and cultural activity around 1800 and in the epochal situation after the (Goethean) ‘art period’. This reference work presents Tieck’s life and times, locates his work in its aesthetic tradition and describes his poetics and commitment as a literary critic, editor and literary scholar. Individual texts are analysed in detail, within the context of his complete work and within the context of their time. Another strong focus lies on the impact and reception of Tieck’s work. The articles are complemented by a complete bibliography of research. * Extensive presentation of the life and work of Ludwig Tieck * Elucidates Tieck’s position in the aesthetic tradition * Overview of the complete work * Interpretations of individual texts within the context of their time * Overview of reception and impact * Complete research bibliography

This new edition features research from nearly 60 of the profession's most distinguished international authorities. Recognizing emerging developments in biopolymer systems research with fully updated and expanded chapters, the second edition discusses the biopolymer-based multilayer structures and their application in biosensors, the progress made in the understanding of protein behaviour at the air-water interface, experimental findings in ellipsometry and reflectometry, and recent developments concerning protein interfacial behaviour in microfabricated total analysis systems and microarrays. With over 3000 references, this is an essential reference for professionals and students in surface, pharmaceutical, colloid, polymer, and medicinal chemistry; chemical, formulation, and application engineering; and pharmacy.

This new edition features research from nearly 60 of the profession's most distinguished international authorities. Recognizing emerging developments in biopolymer systems research with fully updated and expanded chapters, the second edition discusses the biopolymer-based multilayer structures and their application in biosensors, the progress made in the understanding of protein behaviour at the air-water interface, experimental findings in ellipsometry and reflectometry, and recent developments concerning protein interfacial behaviour in microfabricated total analysis systems and microarrays. With over 3000 references, this is an essential reference for professionals and students in surface, pharmaceutical, colloid, polymer, and medicinal chemistry; chemical, formulation, and application engineering; and pharmacy.