This Book Contains A Systematic And Comprehensive Exposition Of Lobachevskian Geometry And The Theory Of Discrete Groups Of Motions In Euclidean Space And Lobachevsky Space. The Authors Give A Very Clear Account Of Their Subject Describing It From The Viewpoints Of Elementary Geometry, Riemannian Geometry And Group Theory. The Result Is A Book Which Has No Rival In The Literature. Part I Contains The Classification Of Motions In Spaces Of Constant Curvature And Non-traditional Topics Like The Theory Of Acute-angled Polyhedra And Methods For Computing Volumes Of Non-euclidean Polyhedra. Part Ii Includes The Theory Of Cristallographic, Fuchsian, And Kleinian Groups And An Exposition Of Thurston's Theory Of Deformations. The Greater Part Of The Book Is Accessible To First-year Students In Mathematics. At The Same Time The Book Includes Very Recent Results Which Will Be Of Interest To Researchers In This Field. I. Geometry Of Spaces Of Constant Curvature / D.k. Alekseevskij, E.b. Vinberg, A.s. Solodovnikov -- Ii. Discrete Groups Of Motions Of Spaces Of Constant Curvature / E.b. Vinberg, O.v. Shvartsman. (ed.) H.b. Vinberg. Translation Of: Geometrii︠a︡ Ii, Issued As V. 29 Of The Serial: Itogi Nauki I Tekhniki. Sovremennye Problemy Matermatiki. Fundamentalʹnye Napravlenii︠a︡. Includes Bibliographical References And Indexes.

This Book Contains A Systematic And Comprehensive Exposition Of Lobachevskian Geometry And The Theory Of Discrete Groups Of Motions In Euclidean Space And Lobachevsky Space. The Authors Give A Very Clear Account Of Their Subject Describing It From The Viewpoints Of Elementary Geometry, Riemannian Geometry And Group Theory. The Result Is A Book Which Has No Rival In The Literature. Part I Contains The Classification Of Motions In Spaces Of Constant Curvature And Non-traditional Topics Like The Theory Of Acute-angled Polyhedra And Methods For Computing Volumes Of Non-euclidean Polyhedra. Part Ii Includes The Theory Of Cristallographic, Fuchsian, And Kleinian Groups And An Exposition Of Thurston's Theory Of Deformations. The Greater Part Of The Book Is Accessible To First-year Students In Mathematics. At The Same Time The Book Includes Very Recent Results Which Will Be Of Interest To Researchers In This Field. I. Geometry Of Spaces Of Constant Curvature / D.k. Alekseevskij, E.b. Vinberg, A.s. Solodovnikov -- Ii. Discrete Groups Of Motions Of Spaces Of Constant Curvature / E.b. Vinberg, O.v. Shvartsman. (ed.) H.b. Vinberg. Translation Of: Geometrii︠a︡ Ii, Issued As V. 29 Of The Serial: Itogi Nauki I Tekhniki. Sovremennye Problemy Matermatiki. Fundamentalʹnye Napravlenii︠a︡. Includes Bibliographical References And Indexes.

It is essential for Criminal Behaviour students to have specific content on the Canadian criminal justice system, Canadian research and Canadian crime. Criminal Behaviour and Psychology is very accessible, and has a focus on empirical research to support key theories and practice. Contemporary themes are also highlighted to give this book a truly Canadian perspective.

Driven by Purpose, Destined for Change is a heartwarming, candid and frank biography of one of Singapore's most prominent entrepreneur and multi-hyphenate, Elim Chew. Elim shares her lesser known familial histories, pangs of growing up, days of being wild, history of retail icon 77th Street, social enterprise, youth mentorships as well as her latest love, fishing. Through the book, we get a deeper understanding of who multi-hyphenate Elim Chew really is, get to share in and learn from her community leadership, business experiences, unique perspective on life and a whole lot of Singlish. She al

The Enlightenment signaled diminished popular reliance on the religious “cure of the soul,” and witnessed the emergence of psychoanalysis. From its inception, Freud’s psychoanalysis was accused of being a “Jewish science,” and he countered by including non-Jewish Swiss psychiatrists in his movement. Carl Jung eventually broke with Freud due to differences concerning psychoanalytical theory and practice. This text explores the religious underpinnings of psychoanalysis, contrasting the textual and mystical traditions of Judaism with those of Christianity. It convincingly demonstrates that differences in the fundamental tenets of Judaism and Christianity have had a profound and continued influence on psychoanalysis.

Die Religionsphilosophie bietet eine zentrale Perspektive auf die Philosophie als ganze. In dieser Perspektive werden die Religion selbst und durch sie Wirklichkeit und Wahrheit philosophisch gedeutet. Auf systematische Fragen der Religion antwortet die Philosophie mit reflexiver Anstrengung.Das Buch verfolgt insbesondere zwei Absichten: Erstens rückt es die Religionsphilosophie von einer randständigen Position ins Zentrum der Philosophie: Religionsphilosophie ist zuallererst Philosophie. Zweitens wird auf diese Weise ein Raum geschaffen, in dem eine Reflexion von Religion möglich ist, die, unabhängig von konfessionell eingeschränkter oder kulturell eingeengter Forschung, dem Wesen der Religion näher kommt. Die Religion ist sowohl für das Menschenbild als auch für die Gesellschaftsordnung eine prägende Kraft. Erscheinungsdatum: 15.06.2017

Die Raumvorstellung des Apostels Paulus bei der Taufe »in Christus« als »neues Sein« des Menschen hat eine große Wirkung auf die verschiedensten Texte des entstehenden Neuen Testaments gehabt. Sie kann mit ihrer breiten Wirkungsgeschichte ein Schlüssel für die in den vergangenen Jahren begonnene Entdeckung der Kirchenraum-Pädagogik und ihre Deutung in Religionspädagogik und Kulturwissenschaft sein. Wie auch der Reformator Martin Luther das Evangelium phänomenologisch räumlich-körperlich ›begriff‹ und für die Kirchengebäude und ihre Raum­gestaltung fruchtbar machen konnte (z.?B. beim Abendmahl), bildet in der Vorbereitung für das Reformationsjubiläum 2017 einen ökumenischen Beitrag in der Debatte um das »Heilige«: »Heilig – in Christus«!

Life narratives and fiction that represent experiences of hermaphroditism and intersex are at the core of Michaela Koch's study. The analyzed texts from the 19th to the early 21st century are embedded within and contrasted with contemporary debates in medicine, psychology, or activism to reveal the processes of negotiation about the meaning of hermaphroditism and intersex. This cultural studies-informed work challenges both strictly essentialist and constructivist notions. It argues for a differentiated perspective on intersex and hermaphrodite experiences as historically contingent, fully embodied, and nevertheless discursive subject positions. Erscheinungsdatum: 01.06.2017

Gerald is careful. Piggie is not. Piggie cannot help smiling. Gerald can. Gerald worries so that Piggie does not have to. Gerald and Piggie are best friends. In I Really Like Slop! , Piggie invites Gerald to try her favorite food . . . slop. But Gerald is not so sure he's going to like it. At all.

El narrador de Doctor Pasavento persigue el destino del escritor suizo Robert Walser, de quien admira su afán por pasar desapercibido, la vida de bella infelicidad que llevó y la extrema repugnancia que le producían el poder y la grandeza literaria. Quiere apartarse, y un día desaparece. Cree que indagarán pero a Pasavento no le busca nadie y poco a poco va imponiéndose la sencilla verdad

Commencing with a self-contained overview of atomic collision theory, this monograph presents recent developments of R-matrix theory and its applications to a wide-range of atomic molecular and optical processes. These developments include the electron and photon collisions with atoms, ions and molecules which are required in the analysis of laboratory and astrophysical plasmas, multiphoton processes required in the analysis of superintense laser interactions with atoms and molecules and positron collisions with atoms and molecules required in antimatter studies of scientific and technologial importance. Basic mathematical results and general and widely used R-matrix computer programs are summarized in the appendices. Erscheinungsdatum: 28.03.2011

In the last decade, the USA and its allies have invaded Afghanistan; Russia has sent troops into Ukraine; Britain and France helped topple a regime in Libya; the militant group ISIS has emerged in the Middle East; and across West Africa, the quest for precious minerals has both financed and caused conflicts. Other conflicts are less bloody, but still dangerous -- the nervous stand-off between India and Pakistan in Kashmir, for instance, or the continuing stalemate between nuclear-armed, totalitarian North Korea and capitalist, democratic South Korea. Can we be truly confident that these arguments will not lead to armed conflict -- whether by design or by human error? In The World in Conflict, John Andrews tackles head-on the reasons why global conflict is an ever-present in our lives. He analyses today's conflicts continent by continent, considering the causes, participants, impact and likely outcomes. He looks at recently-ended wars that remain prone to intermittent fighting. And, crucially, he considers where, why and how new conflicts might erupt. This is a book for our times, an essential guide for anyone and everyone who wants to know more about the world's main danger spots and how and why war and terrorism persist -- in short, how we might better understand our world in conflict.

Collection de documentaires présentant la provenance et la croissance des aliments. On explique dans des termes clairs et concis leurs caractéristiques, leurs provenances et leurs propriétés nutritives. Des recettes, des activités et des encadrés intitulés "Le savais-tu?" agrémentent le tout. Ici, il est question des produits céréaliers et plus spécifiquement de la culture du riz, du blé et du maïs. Des couleurs vibrantes, une mise en pages dynamique et de nombreuses photographies animent le tout. L'assistance d'un adulte est recommandée pour réaliser les recettes. En fin d'ouvrage, des activités sont proposées aux parents et aux enseignants. [SDM].

xi, 191 pages ; 23 cm, Includes bibliographical references (pages 185-191), Machine derived contents note: Preface; 1. Introduction; 2. Silent judgements; 3. Loves and lovers; 4. Pastoral and puritan; 5. Innocence and experience; 6. Action and retirement; 7. Paradise's only map; 8. Panegyrics and satires; Bibliography

Merkwürdig, dass an diesem Abend anscheinend nicht nur Bob und Peter zufällig das Haus des längst verstorbenen Mathias Green besichtigen, das abgerissen werden soll. Mehr als merkwürdig, nämlich höchst gruselig, wenn dann plötzlich ein grün schimmernder Geist erscheint, den auch noch andere bezeugen können. Ein neuer Fall für die drei ???

Collection de documentaires présentant la provenance et la croissance des aliments. On explique dans des termes clairs et concis leurs caractéristiques, leurs provenances et leurs propriétés nutritives. Des recettes, des activités et des encadrés intitulés "Le savais-tu?" agrémentent le tout. Ici, il est question des légumes et plus spécifiquement de la culture des petits pois, de la carotte, de la courgette et de la pomme de terre

At the edge of the forest lives a little mouse. He's the grumpiest and grouchiest mouse for miles around -- until he meets a little lost badger, who desperately needs his help. A heartwarming tale about the happiness that comes from making friends

Merkwürdig, daß an diesem Abend anscheinend nicht nur Bob und Peter zufällig das Haus des längst verstorbenen Mathias Green besichtigen, das abgerissen werden soll. Mehr als merkwürdig, nämlich höchst gruselig, wenn dann plötzlich ein grün schimmernder Geist erscheint, was außer den beiden immerhin sechs ausgewachsene Männer (oder waren es sieben?) bezeugen können. Justus dagegen findet den Bericht seiner Freunde weder sehr merkwürdig noch sehr gruselig, sondern sehr verdächtig - und schon stecken die drei ??? in den Ermittlungen zu einem neuen Fall. Bald stellt sich heraus, daß irgend jemand hinter einer wertvollen Perlenkette her ist, die in dem Abbruchhaus gefunden wurde. Sie ist dem Unbekannten sogar eine Entführung wert, wie Bob, Peter und ein neuer Freunde am eigenen Leibe zu spüren bekommen. Doch Justus wäre nicht Justus, käme ihm nicht rechtzeitig die rettende Erleuchtung... ϡ쯦랠

Merkwürdig, dass an diesem Abend anscheinend nicht nur Bob und Peter zufällig das Haus des längst verstorbenen Mathias Green besichtigen, das abgerissen werden soll. Mehr als merkwürdig, nämlich höchst gruselig, wenn dann plötzlich ein grün schimmernder Geist erscheint, den auch noch andere bezeugen können. Ein neuer Fall für die drei ???. [kinder]

Collection de documentaires présentant la provenance et la croissance des aliments. On explique dans des termes clairs et concis leurs caractéristiques, leurs provenances et leurs propriétés nutritives. Des recettes, des activités et des encadrés intitulés "Le savais-tu?" agrémentent le tout. Ici, il est question des produits laitiers et plus spécifiquement du fromage, du beurre et du lait

Pourquoi faire appel à un cabinet de relations publiques? Quelle valeur ajoutée peut-on tirer de la consultation? Quelle formation, quelle expérience et quelles habiletés les consultants doivent-ils posséder? Comment répondre efficacement aux besoins de la clientèle et en même temps savoir gérer et rentabiliser un cabinet? Voilà quelques-unes des questions auxquelles répond l'auteur de cet ouvrage en esquissant un portrait des meilleures pratiques de la gestion de la clientèle et de celle du cabinet lui-même. Il retrace aussi l'évolution des cabinets de relations publiques au Québec et celle des cabinets et réseaux mondiaux, permettant ainsi au lecteur de mieux saisir les changements profonds qui affectent aujourd'hui la pratique des relations publiques, particulièrement le développement fulgurant des médias sociaux. Les consultants exerceront-ils le même contrôle qu'auparavant sur la communication publique des organisations? Quelles transformations les cabinets devront-ils opérer pour conserver le leadership de la communication? Autant de questions fondamentales pour l'avenir de la profession des relations publiques et de sa pratique en cabinet. Cet ouvrage ne manquera pas d'intéresser les chefs d'entreprises, les conseillers en relations publiques tant dans les organisations que dans les cabinets, ainsi que les enseignants et les étudiants en relations publiques.

Norman W. Simmonds. Bibliography: P. 88-95.

Pourquoi faire appel à un cabinet de relations publiques ? Quelle valeur ajoutée peut-on tirer de la consultation ? Quelle formation, quelle expérience et quelles habiletés les consultants doivent-ils posséder ? Comment répondre efficacement aux besoins de la clientèle et en même temps savoir gérer et rentabiliser un cabinet ? Voilà quelques-unes des questions auxquelles répond l’auteur de cet ouvrage en esquissant un portrait des meilleures pratiques de la gestion de la clientèle et de celle du cabinet lui-même.Il retrace aussi l’évolution des cabinets de relations publiques au Québec et celle des cabinets et réseaux mondiaux, permettant ainsi au lecteur de mieux saisir les changements profonds qui affectent aujourd’hui la pratique des relations publiques, particulièrement le développement fulgurant des médias sociaux. Les consultants exerceront-ils le même contrôle qu’auparavant sur la communication publique des organisations ? Quelles transformations les cabinets devront-ils opérer pour conserver le leadership de la communication ? Autant de questions fondamentales pour l’avenir de la profession des relations publiques et de sa pratique en cabinet.Cet ouvrage ne manquera pas d’intéresser les chefs d’entreprises, les conseillers en relations publiques tant dans les organisations que dans les cabinets, ainsi que les enseignants et les étudiants en relations publiques.

96 p. : 20 cm, The Scream Team's track-and-field season includes events like the wrong jump and the spooky-yard dash. When Patsy the zombie loses her head before the finish line, it's up to Karl and the other speed-demons to help her out, Appeals to 2nd-3rd graders, Reading level grade 3

xxi, 112 p. : 28 cm, \"Prepared for the Department of Veterans Affairs.\", \"National Defense Research Institute and Rand Health.\", \"MG-163-DVA\"--P. [4] of cover, Includes bibliographical references (p. 111-112)

The second volume of the trans-disciplinary series “Research in Peace and Reconciliation” looks at ways of dealing with the past in Sub-Saharan Africa in recent decades and highlights the variety of peaceful strategies and processes. It asks to what extent this variety fosters the development of alternative methods for the transformation of violent conflict.The contributions focus on different African countries and regions as Chad, Nigeria, Rwanda, Uganda, Namibia, Zimbabwe, and South Africa. They take into account the influence of particular cultural contexts on processes of reconciliation. In doing so, they emphasize the importance of religions, rites, and tribal customs as well as the complex legacy of colonialism. They also look at the presentation of the topic in Western media.Many thanks go to the Ernst-Abbe-Foundation (Jena) for its generous support of the publication. Erscheinungsdatum: 16.07.2014

Poster And Theatre Designer, Lithographer, Painter And Creator Of Typefaces, Cassandre, One Of The Greatest Commercial Artists Of This Century, Was Born In The Ukraine In 1901 And Lived For Almost 80 Years. A Friend Of Balthus And De Chirico, Whose Art He Deeply Admired, He Reconciled The Ideas Of Such Contemporary Avant-garde Movements As Cubism, Surrealism And Neue Sachlichkeit, With The Demands Of Commercial Art. Today, Cassandre's Posters Are Avidly Collected By Individuals And Museums. Since The Primary Purpose Of A Poster Is To Generate Consumer Interest, It Is Rare To Find Mint Examples--most Of Them Were Intended As Temporary Displays To Be Posted On Kiosks And Walls, Or To Be Hung In The Offices Of Travel Agents Or Transport Companies. Happily, The Illustrations In This Volume Reproduce Perfect Impressions Of His Finest Posters, Including The Celebrated Dubonnet Piece, The Normandie Poster And The Ones For Pathé Records And The Etoile Du Nord Train. Cassandre's Unerring Graphic Sensibility Was Expressed In A Brilliant Manipulation Of Typography And Image. With Extraordinary Imagination He Transformed Mechanistic Elements Into Components Of An Almost Classical Grandeur. He Also Had A Splendid Colour Sense. This Study--written By His Son Henri Mouron--is The First To Deal With Cassandre's Unique Achievement. With Almost 400 Illustrations, Including Work For The Theatre And For The Great Typesetters Of The Time, As Well As His Posters, It Is A Fascinating Insight Into The World Of Commercial Art, And An Indispensable Tool For Those Interested In The Applied Arts And Advertising. -- Inside Jacket Flap. Henri Mouron ; [translated From The French By Michael Taylor]. Translation Of: A.m. Cassandre. Includes Index. Bibliography: P. 309.

Claudio Moreschini focuses on selected and as yet still understudied aspects of Boethius‘ life and works. He presents Boethius in the culture of the sixth century in Italy, outlines his great cultural project and discusses the problem of his Christian faith. The Consolatio Philosophiae is examined from the point of view of Latin Platonism, highlighting the aims of its poetry and its philosophical tenets. Moreschini also shows how Boethius combined Christian faith and philosophy in order to solve theological issues, most notably the Christological debates of his times or the question of the Trinity. Erscheinungsdatum: 16.07.2014

Gerald is careful. Piggie is not. Piggie cannot help smiling. Gerald can. Gerald worries so that Piggie does not have to. Gerald and Piggie are best friends. In I Really Like Slop! , Piggie invites Gerald to try her favorite food . . . slop. But Gerald is not so sure he's going to like it. At all.

The Enlightenment signaled diminished popular reliance on the religious -cure of the soul, - and witnessed the emergence of psychoanalysis. From its inception, Freud's psychoanalysis was accused of being a -Jewish science, - and he countered by including non-Jewish Swiss psychiatrists in his movement. Carl Jung eventually broke with Freud due to differences concerning psychoanalytical theory and practice. This text explores the religious underpinnings of psychoanalysis, contrasting the textual and mystical traditions of Judaism with those of Christianity. It convincingly demonstrates that differences in the fundamental tenets of Judaism and Christianity have had a profound and continued influence on psychoanalysis.

In the second decade of each century, a new global order commonly starts to assert itself. In the 19th, Napoleon's defeat gave birth to the world of rivalrous European powers. In the 20th, the First World War triggered a wave of revolutions that cleared a path for the American era. Ours appears to be no different.The world is once again on the move: China extends its influence across the globe; Europe is struggling to maintain unity and the United States looks hollowed out by its own past adventures. Meanwhile Russia is up to a lot of startlingly bold new tricks.In this expanded new edition of The World in Conflict, John Andrews tackles head-on the reasons why global violence is ever-present in our lives. He analyses every single one of today's major conflicts region by region, considering the causes, contexts, participants, impacts and likely outcomes. He looks at recently-ended wars that still spawn intermittent fighting. And he considers where, why and how new conflicts might erupt. This is a must-read for our interesting times, a guide to our new world of terrorism, kompromat and cyber war, shifting powers and enduring strife. If you want to know who is fighting where, for what, and whether they can win, The World in Conflict is indispensable.

Bruna es una mujer asediada por las culpas y los miedos, los conflictos y desafíos propios de su generación, a partir del nacimiento de Luz, afectada por parálisis cerebral. A sus treinta y cinco años, tras un largo peregrinaje en busca de raíces, un camino de reconstrucción entre los pedazos dejados por la separación de sus padres, varias parejas fallidas y un aborto a cuestas, la vida decide poner a prueba una vez más a la joven madre, “compañera de barco de la gran familia humana”. La presencia de Luz implica una transformación radical que llevará a Bruna a una forma de ser más madura, profundamente conectada con los valores de la naturaleza y la comunidad, devolviéndole una libertad interior que desemboca en un nuevo sentido de integridad personal. El amor era esto traza una noción de amor basada en el respeto de todas las formas de vida, un tipo de amor que “va más allá de los músculos atrofiados, de la dentadura torcida y la mirada estrábica”, un amor que rompe las barreras que llevan la discapacidad infantil a la exclusión, abandono o rechazo. Un cuento que contempla la preciosa complejidad de los seres, la variabilidad constante, la necesidad de autodescubrimiento y de expresión, un llanto desgarrador que grita sí a la vida. Erscheinungsdatum: 24.01.2021

Gerald is careful. Piggie is not. Piggie cannot help smiling. Gerald can. Gerald worries so that Piggie does not have to. Gerald and Piggie are best friends. In I Love My New Toy! , Piggie can't wait to show Gerald her brand new toy. But will an accidentally broken toy accidentally break a friendship?

Stem Cells Contents Preface Part I Basic Biology 1 Epigenetic Regulation in Pluripotent Stem Cells 1 Introduction 2 DNA Methylation 3 Histone Modifications and Histone Variants 4 Higher-Order Structure of Chromatin 5 X-Chromosome Inactivation 6 Regulation of ESC Pluripotency and Differentiation by miRNAs 7 Telomere Function and Genomic Stability in ESCs 8 Imprinting and ESC Stability 9 Epigenetic Interconversion among Mouse ESCs, EpiSCs, and Human ESCs 10 Summary References 2 Induced Pluripotent Stem Cells 1 Introduction 1.1 What Is Nuclear Reprogramming? 1.2 Knowledge Obtained Using ES Cells 1.3 The Blind Side of ES Cells 2 iPSCs 2.1 Discovery of the Reprogramming Factors 2.2 The Sources of iPS Cells 2.3 The Generation of iPSCs 3 Application of iPS Cells 3.1 iPS Cells as Disease Models 3.2 iPSCs for Regenerative Medicine 4 Conclusions Acknowledgments References 3 Naturally Occurring Adult Pluripotent Stem Cells 1 Introduction 2 What Are Adult Pluripotent Stem Cells? 3 What Are Progenitor Cells? 4 Isolation and Characterization of Pluripotent Stem Cells 5 Differences Between Induced Pluripotent Stem (iPS) Cells and Naturally Occurring Adult Pluripotent Stem Cells 69 6 Locations of Adult Pluripotent Stem Cells 7 Normal Functions of Adult Pluripotent Stem Cells 8 Obtaining Adult Pluripotent Stem Cells 9 The Use of Adult Pluripotent Stem Cells in Regenerative Medicine 10 Proposed Uses for Adult Pluripotent Stem Cells Acknowledgments References 4 Spermatogonial stem cell (SSCs) system Abbreviations 1 Introduction 2 Understanding Stem Cell Genes 2.1 Techniques for Identifying the Anatomy of the Stem Cell 3 The Mammalian Spermatogonial Stem Cell 4 Crucial Signaling Pathways in Regulating the Fate of SS Cells 4.1 Src Signaling Pathway 4.2 Phosphoinositide 3-Kinase (PI3K)/Akt Pathway 4.3 Ras/Erk1/2 Signaling Pathway 4.4 Smad Signaling Pathway 5 MicroRNAs in the Regulation of Spermatogenesis 6 Isolation, Characterization, and Culture of Mouse and Human Spermatogonia 106 6.1 Isolation and Characterization of Rodent Spermatogonia 6.1.1 C-kit in Immature Testis 6.1.2 C-kit and GFRα-1 in Adult Testis 6.1.3 Other Studies and Markers for Mouse SS Cells 6.1.4 Isolation and Characterization of Adult Mouse SS Cells and Aging 6.2 Isolation and Characterization of Human Spermatogonia 6.2.1 GPR125 6.2.2 Other Human Spermatogonial Markers 7 The Significance of SS Cells Outside Their Niche: The Emergence of the Pluripotent Adult Stem Cell 8 Concluding Remarks: Summary of the Significance of SS Cells Acknowledgments References 5 Stem Cell Dormancy: Maintaining a Reserved Population 1 Introduction 2 Purpose of Stem Cell Quiescence and Dormancy 3 History 4 Factors Regulating Quiescence 4.1 Extrinsic Factors Regulating Quiescence: The Stem Cell Niche 4.2 Intrinsic Regulators of Quiescence 5 Factors Regulating Dormancy 5.1 Extrinsic Factors Regulating Dormancy: The Stem Cell Niche 5.2 Intrinsic Regulators of Dormancy 6 Cancer Relevance References 6 Stem Cells in the Adult Brain: Neurogenesis 1 Brief Historical Significance 2 Identity and Properties of Adult Neural Stem Cells 3 Adult Neurogenesis Niche 3.1 The Subventricular Zone (SVZ) 3.2 The Subgranular Zone (SGZ) 4 Regulation of Adult Neural Stem Cells and Neural Progenitor Cells 4.1 Extrinsic Signals 4.2 Intrinsic Regulators 4.3 Neuronal Activity Control 5 Evolving Concepts of Adult Neural Stem Cells 5.1 The Lineages of Adult Neural Stem Cells 5.2 Adult Neural Stem Cell Heterogeneity 5.3 Adult Neurogenesis in Humans 6 Conclusions Acknowledgments References 7 Embryonic Stem Cells 1 Embryonic Development 2 Derivation of ES Cells 3 Basic Properties of ES Cells 4 Similarities and Differences Among ES Cells Derived from Different Species 5 Culturing ES Cells 6 Differentiation of ES Cells and Other Pluripotent Cells 7 Other Stem Cell Populations, ES-Like Cells, Primordial Germ Cell, and Epiblast Cells 8 iPSCs 9 Uses of ES Cells and Other Pluripotent Cells References Further Reading Part II Laboratory Methods 8 Cardiomyocytes from Human Embryonic Stem 1 Introduction 2 Signaling and Regulation in Heart Development: Molecular Insights into hESC Differentiation 2.1 Essential Signaling Pathways in Cardiac Development 2.2 Transcription Factors within Cardiac Regulatory Networks 3 Differentiation of hESCs to Cardiomyocytes 3.1 Spontaneous Differentiation by Embryoid Body Formation 3.2 END2 Coculture 3.3 Directed Differentiation in Defined Media 4 Characterization of hESC-Derived Cardiomyocytes 4.1 Molecular Phenotype 4.2 Transcriptome Analysis 4.3 Electrophysiological Characterization 5 Scale-Up and Enrichment of hESC-CMs 5.1 Scale-Up Platforms 5.2 hESC-CM Enrichment Strategies 6 Translational Research in hESC-CMs 6.1 Cell Therapy for Heart Regeneration 6.2 hESC-CMs for Drug Discovery 7 Conclusions and Future Outlook Acknowledgements References 9 Cloned Mice from Adult Stem Cells 1 Introduction 2 The Success Rate of Mammalian Cloning and Differentiation Status of Donor Cells 2.1 Speculation That the Cloning Efficiency from Adult Stem Cells Is Better Than from Differentiated Cells 2.2 Cloned Mice from Hematopoietic Stem Cells 2.3 Cloned Mice from Neural Stem Cells 2.4 Cloned Mice from Mesenchymal Stem Cells 2.5 Cloned Mice from Keratinocyte Stem Cells 2.6 Cloned Deer from Antler Stem Sells 2.7 Current Understanding of Adult Stem Cells as Nuclear Donors 3 Epigenetic Status of Cloned Animals 3.1 Aberrant Epigenetic Modifications in Cloned Embryos 3.2 Effects of Histone Deacetylase Inhibitors 3.3 Somatic Cell Nuclear Transfer and Telomere Length 4 Application of Somatic Cell Nuclear Transfer Technology 4.1 Establishment of ES Cells Derived from SCNT-Generated Blastocysts 4.2 Therapeutic Application of ntES Cells 4.3 Generating Cloned Mice from ‘‘Unclonable’’ Strains 4.4 Producing Offspring from Infertile Mice 4.5 Possibility of Resurrecting Extinct Animals 5 Conclusions References 10 Cloned Mice from Embryonic Stem Cells 1 Introduction 2 Improvements in the Success Rate of Mouse Somatic Cell Cloning 3 Establishment of ES Cells from Somatic Cells via Nuclear Transfer 3.1 How Normal Are ntES Cells? 3.2 Ethical Problems Regarding ntES Cells 3.3 Avoiding Ethical Problems Associated with ntES Cells by Using Lethally Vulnerable Embryos, or Using Embryos without their Destruction 4 The Value of Mouse Cloning Using an ntES Cell Line 4.1 Applications of ntES Cell Techniques for Therapeutic Medicine 4.2 Improving the Differentiation Potential of Parthenogenetic ES Cells by Nuclear Transfer 4.3 Producing Offspring from Individual Mice, Including Infertile Mice 4.4 The Possibility of Resurrecting an Extinct Animal 5 Conclusions References 11 Haploid Embryonic Stem Cells 1 Introduction 2 History and Rationale 2.1 Haploidy in Evolution 2.2 Haploid Somatic Cell Culture 2.3 Attempts Towards Haploid ES Cell Culture 2.4 Rationale 3 Approaches to Haploid ES Cell Culture 3.1 Production of Haploid Embryos 3.2 Cell Culture Derivation 3.3 Culture Conditions 3.4 Generation of Stable Haploid ES Cell Lines 3.5 Characterization of Haploid ES Cells 3.6 Stable Growth and Genetic Stability 4 Applications of Haploid ES Cells 4.1 Semicloning 4.2 Haploid Genetic Screens 5 Concluding Remarks Acknowledgments References Notes added to proof 12 Muscle Stem Cells: Their Discovery, Properties, and In-Vitro Manipulation 1 Seeking the Source of Skeletal Muscle’s Vast Ability to Repair 1.1 A Brief Overview of Skeletal Muscle Structure, Function, and Regeneration 1.2 The Discovery of Satellite Cells Provides a Candidate Cellular Agent Driving Muscle Regeneration 1.3 Improved Methods for Handling and Characterizing Satellite Cells Enrich Understanding, but Call into Question Muscle Stem Cell Status 2 Vindicating the Satellite Cell as a Muscle Stem Cell: Verification as the Physiological Muscle Stem Cell 2.1 Muscle Stem Cells Must Possess Two Key Traits 2.2 Evidence Emerges for Satellite Cell Self-Renewal In Vivo, Reconfirming Them as the Physiological Muscle Stem Cell 2.3 Satellite Cells Represent a Heterogeneous Population with Varying Potentials 2.4 Cellular Polarization and Stochastic Events Facilitate Satellite Cell Self-Renewal 2.5 Other Cell Types Can Contribute to Myogenesis, Albeit with Varying Efficacies 3 Regulating Muscle Stem Cell Self-Renewal in Culture: In Vivo Lessons and In Vitro Implementations 3.1 Muscle Stem Cell Fate Is Controlled by Multiple Layers of Regulation 3.2 Niche Cues Orient Satellite Cell Polarity and Asymmetry 3.3 Local Factors Crosstalk to Decide Satellite Cell Fate 3.4 Systemic Factors Exert a Long-Range Influence on Satellite Cell Fate 3.5 Mimicking the Muscle Microenvironment In Vitro 3.5.1 Soluble Factors 3.5.2 Substrate and Physical Factors 4 Ongoing Optimization of Muscle Stem Cell Self-Renewal in Culture Acknowledgments References 13 Nuclear Transfer for Cloning Animals 1 Introduction and Brief Historical Overview 2 Key Elements and Critical Aspects of NT Technology 2.1 Nuclear Reprogramming and Epigenetics 2.1.1 DNA Methylation 2.1.2 Histone Modifications 2.1.3 Nuclear Reprogramming by the Blastocyst Stage in Cloned Embryos 2.1.4 Imprinting and Imprinted Genes in Cloned Animals 2.2 Epigenetic Differences between Donor Ce 2.2.1 Embryonic Cell Cloning 2.2.2 Germ Cell Cloning 2.2.3 Somatic Cell Cloning 2.3 Genetic Differences between Donor Cells 2.3.1 Genetic Integrity 2.3.2 Telomeres 2.3.3 Mitochondrial Heteroplasmy 2.3.4 Genetic Background 2.4 Choice of Nuclear Donor Cell Cycle Stage 2.4.1 The Donor Cell Cycle 2.4.2 Cell Cycle Coordination to Maintain Normal Ploidy 2.4.3 Cell Cycle Coordination to Promote Reprogramming 2.5 Reprogramming Ability of the Recipient Cell 2.6 Enucleation 2.7 NT Method 2.7.1 Nuclear Injection 2.7.2 Fusion 2.8 Artificial Activation 2.9 In Vitro Culture of Cloned Embryos 2.10 Transfer of Cloned Embryos 2.11 Pregnancy Monitoring and Progeny Pr 2.12 Adult Clone Phenotypes 2.13 Trans-Generational Effects 3 Applications of NT in Different Species 3.1 Non-Mammalian Species: Frog and Fish 3.2 Laboratory Animal Species: Mouse, Rat, and Rabbit 3.3 Farm Animal Species: Sheep, Cattle, Goat, Pig, Buffalo, and Horse 3.3.1 Safety of Food Products from Cloned Farm Animals 3.4 Endangered Species and Companion Animals 3.5 Humans and Nonhuman Primates 3.6 Ethical and Animal Welfare Aspects of NT Research 4 Future Perspectives of NT Acknowledgments References 14 Induction of Pluripotent Stem Cells from Umbilical Cord Blood 1 Introduction 2 The iPSC Technology 3 Sources of Human Cells for hiPSC Generation 4 Cord Blood as the Premium Tissue for Reprogramming 5 Reprogramming Human Cord Blood with Integrating Vectors 6 Reprogramming Cord Blood with Non-Integrating Episomal System 7 Epigenetic Memory and Genetic Stability of Blood-Derived iPSCs 8 Concluding Remarks Acknowledgments References 15 Development and Renewal of Ventricular Heart Muscle from Intrinsic Progenitor Cells 1 Introduction 2 Perspectives on Stem/Progenitor Cells in the Developing Heart 3 Emergence of Cardiac Progenitors in the Embryo 4 Specification of the Early Cardiogenic Fate 5 Progenitors in the First Heart Field 6 Progenitors in the Second Heart Field 7 Regional Specification of the Developing Heart 8 Epicardial Progenitor Cells 9 Postnatal Cardiomyocyte Turnover 10 Postnatal and Adult Cardiac Stem/Progenitor Cells 11 Cardiac Stem/Progenitor Cells for Postnatal Myocardial Regeneration 12 Conclusion References Part III Stem Cell Therapy 16 Gene Therapy of Genetic Diseases of Blood Cells 1 Genetic Diseases of Blood Cells 2 Allogeneic HSCT as Treatment of Genetic Diseases of Blood Cells 3 Gene Therapy 4 Severe Combined Immune Deficiency (SCID) 4.1 Introduction 4.2 SCID due to ADA Deficiency 4.3 X-Linked SCID 5 Wiskott–Aldrich Syndrome 6 Chronic Granulomatous Disease 7 Hemoglobinopathies 8 Lysosomal Storage Diseases and Metabolic Diseases 9 Gene Correction by Homologous Recombination 10 Summary References 17 Mesenchymal Stem Cells Characteristics, Niches, and Applications for Cell Therapy 1 Introduction 2 MSC Sources and Isolation 2.1 Historical Perspective of MSCs 2.2 Sources and Isolation of MSCs 2.3 Bone Marrow Stem Cell Niche 3 MSC Characteristics 3.1 In Vitro Culture 3.2 Differentiation 4 MSCs and Immunomodulation 4.1 MSC Effects on Immune Cells 4.2 Mechanisms of MSC Immunosuppression 5 MSC Therapy 5.1 Animal Models 5.2 Clinical Trials 6 MSCs and Cancer 6.1 MSCs: Cancer-Promoting or Cancer-Suppressive? 6.2 MSCs as Delivery Vectors for Cancer Therapy 7 Concluding Remarks Acknowledgments References 18 Stem Cells and Parkinson’s Disease 1 Introduction 1.1 Parkinson’s Disease and the Nigrostriatal Dopaminergic System 1.2 Current Therapy of PD 2 Neuroregeneration and Cell Therapy 2.1 Principle 2.2 The Foundation of Neural Cell Transplantation in PD 3 Novel Stem Cell Sources for Neural Cell Therapy 3.1 Overview and Definitions 3.2 Somatic Stem Cells 3.2.1 Fetal Neural Stem Cells 3.2.2 Adult Neural Stem Cells 3.2.3 Other Somatic Cell Types (e.g., Mesenchymal Stem Cells) 3.3 Pluripotent Stem Cells 3.3.1 Overview 3.3.2 Pluripotent Stem Cells: Embryonic Stem Cells 3.3.3 Pluripotent Stem Cells: Induced Pluripotent Stem Cells 3.3.4 Markers of Pluripotency 4 Neural and Dopaminergic Differentiation of Human Pluripotent Stem Cells 4.1 Neural Induction and Early Midbrain Domain Patterning 4.1.1 Markers of Neural Differentiation 4.2 Dopaminergic Differentiation 4.2.1 Markers of Dopaminergic Differentiation 5 Neural Cell Sorting 6 Current Challenges and Outlook 6.1 Clinical Demands 6.2 In-Vitro Assays 6.3 Direct Conversion 6.4 In-Vivo Recruitment 7 Summary and Conclusion References 19 Stem Cell-Based Approaches to Spinal Cord Injury 1 Introduction 1.1 Epidemiology 1.2 Pathophysiology 1.3 Stem Cell Transplantation Benefits 2 Stem Cells: An Overview 3 Endogenous Neural Progenitor Cells 3.1 Bone Marrow Stem Cells, Mesenchymal Stem Cells, and Umbilical Cord Stem Cells 3.2 iPS Cells 4 Embryonic Stem Cells 5 Stem Cell Growth 6 Predifferentiation of ESC Cells 6.1 OPCs 6.2 MNP Cells 7 Clinical Trials 8 Clinical Concerns 9 Summary and Conclusion References 20 Therapeutics against Cancer Stem Cells: Targeting the Root of Cancer 1 Introduction 2 Cancer Stem Cells 2.1 Properties of Cancer Stem Cells 2.2 Complexities of the Cancer Stem Cell Model 3 Stem Cell-Related Signaling Pathways 3.1 Wnt/β-Catenin 3.2 Hedgehog 3.3 Notch 4 Additional Cancer Stem Cell Targets 4.1 NF-κB 4.2 PI3K/AKT/mTOR 4.3 Telomerase 5 Cancer Stem Cell Niche 6 CSCs in Drug Discovery 7 Concluding Remarks References 21 Translating Stem Cells to the Clinic: From Modeling Disease to CellularProducts 1 Introduction 1.1 Generation, Regeneration, and Cellular Plasticity: An Historical Overview 1.2 The Birth of Stem Cell Research 2 The Promises of Pluripotency 2.1 Achieving Pluripotency in a Culture Dish: State of the Art 2.1.1 Embryonal Carcinoma Cells 2.1.2 Embryonic Stem Cells 2.1.3 Embryonic Germ Cells 2.1.4 Induced Pluripotent Stem Cells 2.2 The Dark Side of Pluripotent Stem Cells: Slowing Down Therapeutic Applications 2.2.1 Ethical Issues 2.2.2 The Pluripotency-Associated Cancer Risks 2.2.3 Pluripotent-Associated Immunogenicity 2.3 Pluripotent Cells and Differentiation: Raising Hopes for the Clinic 2.3.1 Generation of Clinically Relevant Cells in a Culture Dish 3 Lineage Conversion and Plasticity: New Kids for the Future of Regenerative Medicine 4 Multipotent Adult Stem Cells: The Alternative to Pluripotency 4.1 Generalities 4.2 Mesenchymal Stem Cells: On the Way to the Clinic 5 Gene Editing and Disease Modeling 6 Conclusions References Part IV Stem Cells and Disease 22 Cancer Stem Cells 1 Introduction 2 Identification and Characterization of the CSCs 2.1 Identification 2.2 Cell of Origin of CSCs 2.3 Are CSCs a Rare Population within a Tumor? 2.4 Quiescence of the Stem Cells 2.5 Cell Plasticity 2.6 Circulating Tumor Cells 3 Signaling Pathways and Factors Involved in the Regulation of CSCs 3.1 Wnt/β-Catenin Canonical Signaling Pathways 3.2 Hedgehog (Hh) Signaling Pathway 3.3 Notch Signaling Pathw 3.4 PI3K/Akt/PTEN Signaling Pathway 3.5 Tumor Suppressor p53 3.6 MicroRNAs (miRNAs) 4 CSCs and the Microenvironment 5 Radiation and Chemotherapy Resistance of CSCs 6 Targeting CSCs 6.1 Targeting CSCs and Their Microenvironment 6.2 Targeting CSCs while Sparing the Normal Stem Cells 7 Conclusions References 23 Normal and Neoplastic Stem Cells 1 Introduction 2 Characteristics and Functions of Stem cells 2.1 General Characteristics 2.2 The Hierarchy of the Hematopoietic System as Model 2.3 Intestinal Stem Cells 2.4 Regulatory Network 2.4.1 Wnt-Signaling 2.4.2 Notch Signaling 2.4.3 The Hedgehog–BMP Axis 2.4.4 The Polycomb Group Gene Bmi1 3 Neoplastic Stem Cells 3.1 Tumor as an Abnormal Organ 3.2 Recent Evidence for Neoplastic Stem Cells in Acute Myeloid Leukemia and Breast Cancer 3.3 Self-Renewal 3.4 Deregulation of Signaling 3.5 Epithelial–Mesenchymal Transition, Metastases, and Neoplastic Stem Cells 3.6 Drug Resistance 4 Implications of Neoplastic Stem Cells for the Treatment of Cancer 4.1 Agents Targeting Surface Markers and Receptors 4.2 Agents Targeting Neoplastic Stem Cell-Specific Signaling Pathways 4.3 Targeting Downstream/Interacting Pathways of Neoplastic Stem Cell Signaling 4.4 Epigenetic Approaches 4.5 Combination Therapy Options 5 Conclusions References 24 Prostate Tissue Stem Cells and Prostate Cancer Progression 1 Introduction 1.1 Conceptual Overview: Stem Cells and Cancer Stem Cells 1.2 Prostate Histology, Cell Lineages, and Morphogenesis 1.3 Prostate Cancer Pathology 2 Mouse Prostate Stem and Progenitor Cells 2.1 Normal Prostate Tissue Reconstituting Cells 2.2 Tumor Initiation and CSCs in Basal and Luminal Cell Compartments 3 Human Prostate Stem Cells 3.1 Normal Human Prostate (NHP) Cells and Immortalization 3.2 CSC Analysis in Prostate Cancer Cell Lines and Xenografts 3.3 Primary Human Prostate Cancer 4 Molecular Mechanisms Regulating Prostate Cell Fate 5 Outstanding Questions Acknowledgments References 25 The Stem Cell Niche and Its Role in Self-Renewal, Aging, and Malignancy 1 The Stem Cell Niche and Its Role in Stem Cell Self-Renewal 1.1 Concept of the Stem Cell 1.1.1 Stem Cell Self-Renewal 1.1.2 Cell-Intrinsic Machinery Controls Stem Cell Self-Renewal 1.2 Concept of the Stem Cell Niche and Regulation of Stem Cell Self-Renewal 1.2.1 Stationary Components of the Stem Cell Niche 1.2.2 Support Cells 1.2.3 Extracellular Components 2 The Stem Cell Niche and Its Role in Aging 2.1 Age-Associated Changes in Stem Cell Behaviors 2.1.1 Aging in Hematopoietic Stem Cells 2.1.2 Aging in Neural Stem Cells 2.1.3 Aging in Muscle Stem Cells 2.2 Aging-Related Alterations in Cell-Intrinsic Signaling Pathways 2.3 The Aging Stem Cell Niche 3 The Stem Cell Niche and Its Role in Carcinogenesis 3.1 Cancer Stem Cell Concept 3.1.1 Cancer Initiator Cells, the Origin of Cancer 3.1.2 Cancer Stem Cells, Cancer Progression, Metastasis, and Relapse 3.1.3 Cancer Stem Cells are Relatively Chemo- and Radio-Resistant 3.1.4 Complexity of Cancer Stem Cells 3.2 Cancer Stem Cell Niches 3.2.1 Contribution of the Niche Microenvironment to Tumorigenesis 3.2.2 The Role of the Normal Stem Cell Niche in Tumorigenesis 3.2.3 The Potential Components of CSC Niches 3.2.4 The Contribution of BM-Derived Inflammatory Cells to the CSC Niche 3.2.5 The CSC Niche and Drug Resistance References 26 Stem Cells and Colon Cancer 1 Colorectal Cancer 1.1 Stochastic versus Hierarchical Model in Cancer Origin 1.2 Colon Crypt and Cancer Stem Cell Characterization 1.3 Stemness Niche: Definition, Role, and Pathways Involved in Its Modulation 2 Treatment Option Overview: Strategy of Treatment by Stage 2.1 Adjuvant Chemotherapy for Stage II CRC 2.2 Adjuvant Chemotherapy for Stage III CRC 2.3 Adjuvant Chemotherapy for Stage IV and Recurrent Colon Can 2.4 Target Therapy: Bevacizumab, Cetuximab/Panitumumab 2.5 Alternative Therapies: mTOR, Protein Kinase C, and Src Inhibitors 3 Targeting the Differentiation and Survival Signaling in CSCs 3.1 Immunotherapy Acknowledgments References Index

Driven by Purpose, Destined for Change is a heartwarming, candid and frank biography of one of Singapore’s most prominent entrepreneur and multi-hyphenate, Elim Chew. Elim shares her lesser known familial histories, pangs of growing up, days of being wild, history of retail icon 77th Street, social enterprise, youth mentorships as well as her latest love, fishing. Through the book, we get a deeper understanding of who multi-hyphenate Elim Chew really is, get to share in and learn from her community leadership, business experiences, unique perspective on life and a whole lot of Singlish. She also provides insight into newly independent Singapore in the 1970s as well as an insider’s glimpse into pop culture in the rocking 1980s and 1990s. You will also get to know more of Elim’s hair-raising past, present motivations and future visions. The book is written with reflections, take away lessons, engaging entrepreneurial tips and activities for anyone who wishes to be Driven by Purpose and Destined for Change.

By Dale L. Hiestand And Dean W. Morse ; Foreword By Eli Ginzberg. Landmark Studies.

<p>Cries in the Night is the story of seven Catholic women who defied Hitler and the Nazis during the Holocaust by saving Jews. Phayer and Fleischner show that these women, motivated by compassion and a sense of justice, to be sure, also strongly desired that their church take up the cause of the Jews during the Holocaust. These women beleived that the true mission of the Chruch lay not in preserving the Chruch's external structure and buildings, but in defending the oppressed.</p>

El narrador de Doctor Pasavento persigue el destino del escritor suizo Robert Walser, de quien admira su afn por pasar desapercibido, la vida de bella infelicidad que llev y la extrema repugnancia que le producan el poder y la grandeza literaria. Quiere apartarse, y un da desaparece. Cree que indagarn pero a Pasavento no le busca nadie y poco a poco va imponindose la sencilla verdad: nadie piensa en l. Le veremos entonces recurrir a esa estrategia de la renuncia que es el acto extremo con el cual algunos raros escritores se aseguran el nico modo de captar el destello de la vida plena e inexpresable, no sofocada por el poder. Viaja al manicomio suizo donde Walser vivi tantos aos apartado del mundo y se acerca al ejercicio de un arte muy peculiar y en el que su escritor ms admirado fue un consumado maestro: el arte de convertirse en nada.

NEW YORK TIMES BESTSELLER • “A gem of a novel.”—Jodi Picoult, #1 New York Times bestselling author of A Spark of Light and Small Great ThingsFrom the #1 New York Times bestselling author of The Party Crasher and Love Your Life comes an irresistible story of love and empowerment about a young woman with a complicated family, a handsome man who might be “the one,” and an IOU that changes everything.Fixie Farr has always lived by her father's motto: “Family first.” And since her dad passed away, leaving his charming housewares store in the hands of his wife and children, Fixie spends all her time picking up the slack from her siblings instead of striking out on her own. The way Fixie sees it, if she doesn't take care of her father's legacy, who will? It's simply not in Fixie's nature to say no to people. So when a handsome stranger in a coffee shop asks her to watch his laptop for a moment, she not only agrees—she ends up saving it from certain disaster. To thank Fixie for her quick thinking, the computer's owner, Sebastian, an investment manager, scribbles an IOU on a coffee sleeve and attaches his business card. Fixie laughs it off—she'd never actually claim an IOU from a stranger. Would she? But then Fixie's childhood crush, Ryan, comes back into her life, and his lack of a profession pushes all of Fixie's buttons. As always, she wants nothing for herself—but she'd love Seb to give Ryan a job. No sooner has Seb agreed than the tables are turned once more and a new series of IOUs between Seb and Fixie—from small favors to life-changing moments—ensues. Soon Fixie, Ms. Fixit for everyone else, is torn between her family and the life she really wants. Does she have the courage to take a stand? Will she finally grab the life, and love, she really wants?Praise for I Owe You One“This book is a shot of pure joy!”—Jenny Colgan, author of The Bookshop on the Corner “A humorous exploration of family life, finding love and the difficulties of coming into one's own as a young professional woman... The entertaining cast of characters... will certainly remind readers why nineteen years after her first hit Kinsella remains one of the reigning queens of women's fiction.”—The Washington Post “I Owe You One is another impossibly delightful story by Sophie Kinsella, a must-read for her die-hard fans and new readers alike.”—PopSugar

El narrador de Doctor Pasavento persigue el destino del escritor suizo Robert Walser, de quien admira su afn por pasar desapercibido, la vida de bella infelicidad que llev y la extrema repugnancia que le producan el poder y la grandeza literaria. Quiere apartarse, y un da desaparece. Cree que indagarn pero a Pasavento no le busca nadie y poco a poco va imponindose la sencilla verdad: nadie piensa en l. Le veremos entonces recurrir a esa estrategia de la renuncia que es el acto extremo con el cual algunos raros escritores se aseguran el nico modo de captar el destello de la vida plena e inexpresable, no sofocada por el poder. Viaja al manicomio suizo donde Walser vivi tantos aos apartado del mundo y se acerca al ejercicio de un arte muy peculiar y en el que su escritor ms admirado fue un consumado maestro: el arte de convertirse en nada.

Die Auseinandersetzung mit Konstruktivismus und Sprachpragmatik sowie der cultural turn in den Sozialwissenschaften eröffnen auch für die Psychologie neue Perspektiven. In welchem Sinn sind psychische Phänomene soziokulturelle Konstruktionen? Worauf beziehen sich dann psychologische Begriffe? Der Soziale Konstruktionismus nimmt diese Fragen auf und plädiert für eine Psychologie, die soziale Prozesse und Diskurse ins Zentrum rückt. Die Autorin verknüpft seine Rekonstruktion mit der Problematisierung des kognitivistischen Wissensbegriffs und des ihm zugrunde liegenden Sprachmodells. Abschließend werden pragmatistische und kulturpsychologische Erweiterungen stark gemacht. Durch den breiten und systematischen Zugang ist der Band auch als Einführung in die Wissenspsychologie geeignet. Erscheinungsdatum: 01.04.2004

NEW YORK TIMES BESTSELLER • “A gem of a novel.”—Jodi Picoult, #1 New York Times bestselling author of A Spark of Light and Small Great ThingsFrom the #1 New York Times bestselling author of The Party Crasher and Love Your Life comes an irresistible story of love and empowerment about a young woman with a complicated family, a handsome man who might be “the one,” and an IOU that changes everything.Fixie Farr has always lived by her father's motto: “Family first.” And since her dad passed away, leaving his charming housewares store in the hands of his wife and children, Fixie spends all her time picking up the slack from her siblings instead of striking out on her own. The way Fixie sees it, if she doesn't take care of her father's legacy, who will? It's simply not in Fixie's nature to say no to people. So when a handsome stranger in a coffee shop asks her to watch his laptop for a moment, she not only agrees—she ends up saving it from certain disaster. To thank Fixie for her quick thinking, the computer's owner, Sebastian, an investment manager, scribbles an IOU on a coffee sleeve and attaches his business card. Fixie laughs it off—she'd never actually claim an IOU from a stranger. Would she? But then Fixie's childhood crush, Ryan, comes back into her life, and his lack of a profession pushes all of Fixie's buttons. As always, she wants nothing for herself—but she'd love Seb to give Ryan a job. No sooner has Seb agreed than the tables are turned once more and a new series of IOUs between Seb and Fixie—from small favors to life-changing moments—ensues. Soon Fixie, Ms. Fixit for everyone else, is torn between her family and the life she really wants. Does she have the courage to take a stand? Will she finally grab the life, and love, she really wants?Praise for I Owe You One“This book is a shot of pure joy!”—Jenny Colgan, author of The Bookshop on the Corner “A humorous exploration of family life, finding love and the difficulties of coming into one's own as a young professional woman... The entertaining cast of characters... will certainly remind readers why nineteen years after her first hit Kinsella remains one of the reigning queens of women's fiction.”—The Washington Post “I Owe You One is another impossibly delightful story by Sophie Kinsella, a must-read for her die-hard fans and new readers alike.”—PopSugar

Gerald is careful. Piggie is not. Piggie cannot help smiling. Gerald can. Gerald worries so that Piggie does not have to. Gerald and Piggie are best friends. In I Love My New Toy! , Piggie can't wait to show Gerald her brand new toy. But will an accidentally broken toy accidentally break a friendship?

El narrador de Doctor Pasavento persigue el destino del escritor suizo Robert Walser, de quien admira su afán por pasar desapercibido, la vida de bella infelicidad que llevó y la extrema repugnancia que le producían el poder y la grandeza literaria. Quiere apartarse, y un día desaparece. Cree que indagarán pero a Pasavento no le busca nadie y poco a poco va imponiéndose la sencilla verdad: nadie piensa en él. Le veremos entonces recurrir a esa estrategia de la renuncia que es el acto extremo con el cual algunos raros escritores se aseguran el único modo de captar el destello de la vida plena e inexpresable, no sofocada por el poder. Viaja al manicomio suizo donde Walser vivió tantos años apartado del mundo y se acerca al ejercicio de un arte muy peculiar y en el que su escritor más admirado fue un consumado maestro: el arte de convertirse en nada.

xi, 336 p. : 26 cm "Proceedings of the Technology Commercialization Conference, held March 1993, in Sante Fe, New Mexico"--T.p. verso Includes bibliographical references and index

Wie viel Liebe verträgt eine Freundschaft?Dieser Roman handelt vom verpassten und verspielten Glück und von dem Unglück, im rechten Moment die falschen Worte gesagt zu haben. Er erzählt die Geschichte zweier Männer und einer Frau, die ihre Freundschaft und ihre Liebe aufs Spiel setzen. Tom Holler, halbwegs erfolgreicher Pianist und frisch getrennt von seiner Frau, tourt mit seiner Berliner Band durch Italien. In Neapel hofft er seine große Liebe wiederzutreffen: Betty Morgenthal. Doch je näher ihre Begegnung rückt, desto tiefer taucht Tom in die Vergangenheit ein. Denn vor vielen Jahren verunglückte Marc, sein bester Freund und Bettys Lebensgefährte. Er hat keine andere Wahl, als die fatale Dreiecksgeschichte noch einmal zu erleben. Berlin und Italien, Leichtsinn und Schwermut, Witz und Dramatik, die lauten und die leisen Töne – dieser Debütroman ist voller Musik. „Es ist unerhört selten, dass eine Frau mit dieser Gerechtigkeit, jenseits aller Klischees, über einen Mann schreibt. Was für ein Roman!“ Michael Kumpfmüller „Untergründig und scharfsinnig und im nächsten Moment sehr poetisch und heiter." Rainer MerkelWörter : 155805Auszeichnung : DBP - 2013 - Shortlist

Our frequent urban companion, cooing in the eaves of train stations or scavenging underfoot for breadcrumbs and discarded French fries, the pigeon has many detractors—and even some fans. Written out of love for and fascination with this humble yet important bird, Barbara Allen's Pigeon explores its cultural significance, as well as its similarities to and differences from its close counterpart, the dove. While the dove is seen as a symbol of love, peace, and goodwill, the pigeon is commonly perceived as a filthy, ill-mannered flying rodent, a "rat with wings." Readers will find in Pigeon an enticing exploration of the historical and contemporary bonds between humans and these two unique and closely related birds. For polluting statues and architecture, the pigeon has earned a bad reputation, but Barbara Allen offers several examples of the bird's importance—as a source of food and fertilizer, a bearer of messages during times of war, a pollution monitor, and an aid to Charles Darwin in his pivotal research on evolutionary theory. Allen also comments on the literary love and celebration of pigeons and doves in the work of such writers and poets as Shakespeare, Dickens, Beatrix Potter, Proust, and Isaac Bashevis Singer. Along the way, Allen corrects the many stereotypes about pigeons in the hope that the rich history of one of the oldest human-animal partnerships will be both admired and celebrated.