The potential for malfunction of this large number of complex biological systems is great, leading to the many behavioral and cognitive deficits observed in human psychiatric and neurological disorders. Genomics, Proteomics, and the Nervous System discusses research designed to increase our understanding of the nervous system and its structures and activities. This volume of Advances in Neurobiology discusses the utilization of genomic and proteomic technologies, to address facets of neurobiology including development and epigenetic regulation, functions in learning and memory, and changes associated with neurological and psychiatric disorders.

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nexusstc/Genomics, Proteomics, and the Nervous System/ff6f9837281958a02ee018de1a7e42b7.pdf

scihub/10.1007/978-1-4419-7197-5.pdf

zlib/Medicine/Phoebe M. Y. Lynn, Evangelia Stergiakouli, William Davies (auth.), James D Clelland (eds.)/Genomics, Proteomics, and the Nervous System_865217.pdf

James D. Clelland, editor

Clelland, James D

Springer Verlag

Advances in neurobiology -- 2, Advances in neurobiology -- 2., Berlin, Germany, 2011

Advances in neurobiology, 2, New York, ©2011

Advances in neurobiology, New York, 2010

United States, United States of America

Springer Nature, New York, 2011

2011, 2010

до 2011-01

sm41108608

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Includes bibliographical references and index.

Front Matter....Pages i-xv
Front Matter....Pages 1-1
The Genomics of Turner Syndrome and Sex-Biased Neuropsychiatric Disorders....Pages 3-20
Mental Retardation and Human Chromosome 21 Gene Overdosage: From Functional Genomics and Molecular Mechanisms Towards Prevention and Treatment of the Neuropathogenesis of Down Syndrome....Pages 21-86
Epigenetic Programming of Stress Responses and Trans-Generational Inheritance Through Natural Variations in Maternal Care....Pages 87-112
Prenatal Viral Infection in Mouse: An Animal Model of Schizophrenia....Pages 113-136
Proteomic Actions of Growth Hormone in the Nervous System....Pages 137-158
Front Matter....Pages 159-159
Gene Expression and Signal Transduction Cascades Mediating Estrogen Effects on Memory....Pages 161-176
Diagnostic Genome Profiling in Mental Retardation....Pages 177-194
Genomic Imprinting and Sexual Experience-Dependent Learning in the Mouse....Pages 195-225
Proteomic Analysis of the Postsynaptic Density....Pages 227-249
Front Matter....Pages 251-251
Functional Genomic Dissection of Speech and Language Disorders....Pages 253-278
Studying Human Circadian Behaviour Using Peripheral Cells....Pages 279-302
Genome-Wide Expression Profiles of Amygdala and Hippocampus in Mice After Fear Conditioning....Pages 303-329
Front Matter....Pages 331-331
Genetic Studies of Schizophrenia....Pages 333-380
Proteomics of the Anterior Cingulate Cortex in Schizophrenia....Pages 381-398
Proteome Effects of Antidepressant Medications....Pages 399-441
Front Matter....Pages 443-443
MicroRNAs in Neurodegenerative Disorders....Pages 445-454
Specific and Surrogate Cerebrospinal Fluid Markers in Creutzfeldt–Jakob Disease....Pages 455-467
Genome-Wide Expression Studies in Autism-Spectrum Disorders: Moving from Neurodevelopment to Neuroimmunology....Pages 469-487
Protein Expression Profile of Alzheimer’s Disease Mouse Model Generated by Difference Gel Electrophoresis (DIGE) Approach....Pages 489-510
Proteomic Analysis of CNS Injury and Recovery....Pages 511-536
Front Matter....Pages 443-443
MALDI Imaging of Formalin-Fixed Paraffin-Embedded Tissues: Application to Model Animals of Parkinson Disease for Biomarker Hunting....Pages 537-556
Comparative Proteomic Analysis as a Method to Investigate Inflammatory and Neuropathic Pain....Pages 557-582
Back Matter....Pages 583-592

Complex behaviours are the product of intercellular signalling events, but their intracellular effectors are present in most cell types. The best-studied example of such architecture is the circadian clock, which directs all diurnal behaviour and physiology, and whose central mechanism is present in most body cells. We present below a method to look at its properties via transcriptional reporters virally delivered to primary cells. By studying primary fibroblasts cultivated from skin biopsies in different human subjects, we have been able to analyse the molecular underpinnings of variance in human daily behaviour. Similar methodologies could be applied to other signalling pathways

This newest volume of "Advances in Neurobiology" discusses the utilization of genomic and proteomic technologies, to address facets of neurobiology including development and epigenetic regulation, functions in learning and memory, and changes associated with neurological and psychiatric disorders

2011-06-04