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lgli/G:\!upload\!add\biology\Cell and Molecular Biology\Molecular Biology of the Parathyroid - Tally Naveh-Many.djvu
Molecular Biology of the Parathyroid (Molecular Biology Intelligence Unit) 🔍
[edited by] Tally Naveh-Many Springer US, Molecular Biology Intelligence Unit, 1, 2005
英语 [en] · DJVU · 4.1MB · 2005 · 📘 非小说类图书 · 🚀/lgli/lgrs · Save
描述
The unraveling of the biology and disease mechanisms of the parathyroid has taken great strides in the recent few years. Parathyroid molecular biology is the first book to describe in detail, recent studies and discoveries in the field. Key topics addressed include:
The study of the molecular biology of the parathyroid hormone gene and its regulation by calcium, phosphate and vitamin D.
The generation of Mice with genetic deletions of the parathyroid, as well as mice which fail to develop the parathyroid gland.
The parathyroids connection to the calcium receptor and it's effects such as regulation of PTH secretion, gene expression and proliferation.
The genetic mutations leading to diseases of decreased or excessive activity of the parathyroid
The mechanisms of actions associated with patients with chronic renal failure and the development of markedly excessive activity of the parathyroid that causes severe bone disease.
This book will be essential reading to everyone interested in the latest developments in this burgeoning field.
备用文件名
lgrsnf/G:\!upload\!add\biology\Cell and Molecular Biology\Molecular Biology of the Parathyroid - Tally Naveh-Many.djvu
备用出版商
Landes Bioscience/Eurekah.com ; Kluwer Academic/Plenum; Kluwer Academic/Plenum
备用出版商
Da Capo Press, Incorporated
备用出版商
Hachette Books
备用出版商
Hachette GO
备用版本
Molecular biology intelligence unit (Unnumbered), Georgetown, Tex. : New York, N.Y, ©2005
备用版本
Georgetown, TX, New York, NY, United States, 2004
备用版本
United States, United States of America
备用版本
Springer Nature, Georgetown, Tex, 2005
备用版本
1 edition, February 1, 2005
元数据中的注释
lg241722
元数据中的注释
Molecular Biology Intelligence Unit
备用描述
aintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu M lar calcium levels, by acting on bone, kidney and intestine. The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex pression to its intracellular processing and the sequences in the gene control ling its transcription as well as those regulating mRNA processing, stability and translation are described.
Erscheinungsdatum: 01.02.2005
备用描述
1. Development Of Parathyroid Glands / Thomas Gunther And Gerard Karsenty -- 2. Parathyroid Hormone, From Gene To Protein / Osnat Bell, Justin Silver And Tally Naveh-many -- 3. Toward An Understanding Of Human Parathyroid Hormone Structure And Function / Lei Jin, Armen H. Tashjian, Jr., And Faming Zhang -- 4. The Calcium Sensing Receptor / Shozo Yano And Edward M. Brown -- 5. Regulation Of Parathyroid Hormone Mrna Stability By Calcium And Phosphate / Rachel Kilav, Justin Silver And Tally Naveh-many -- 6. In Silico Analysis Of Regulatory Sequences In Human Parathyroid Hormone Gene / Alexander Kel, Maurice Scheer And Hubert Mayer -- 7. Regulation Of Parathyroid Hormone Gene Expression By 1,25-dihydroxyvitamin D / Tally Naveh-many And Justin Silver -- 8. Vitamin D Analogs For The Treatment Of Secondary Hyperparathyrodism In Chronic Renal Failure / Alex J. Brown -- 9. Parathyroid Gland Hyperplasia In Renal Failure / Adriana S. Dusso, Mario Cozzolino And Eduardo Slatopolsky -- 10. Molecular Mechanisms In Parathyroid Tumorigenesis / Eitan Friedman -- 11. Molecular Genetic Abnormalities In Sporadic Hyperparathyroidism / Trisha M. Shattuck, Sanjay M. Mallya And Andrew Arnold -- 12. Genetic Causes Of Hypoparathyroidism / Rachel I. Gafni And Michael A. Levine -- 13. Skeletal And Reproductive Abnormalities In Pth-null Mice / Dengshun Miao [and Others]. [edited By] Tally Naveh-many. Includes Bibliographical References And Index. Mode Of Access: World Wide Web.
开源日期
2010-04-25
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