The publication of this volume of The Viruses entitled The Togaviridae and Flaviviridae comes at an appropriate time. The structure and rep lication strategies of these viruses are now known to be sufficiently di verse to warrant the removal of flaviviruses from the Togaviridae family and establish them as an independent family. Flaviviridae have a special place in the history of virology. The prototype virus-yellow fever virus was the first virus to be identified as the cause of a human disease. Some of the history of this discovery is described in Chapter 1 of this volume; in Chapter 10 the complete sequence of the RNA genome of the virus is presented. This sequence not only defines the primary structure of the viral proteins, it also clarifies the mechanism of translation of the fla vivirus genome. Knowledge of the sequence of the structural proteins of these viruses represents an important step in the potential goal of using purified flavivirus glycoproteins as vaccines. Many of the chapters in this volume focus on the structure and replication of the Togaviridae. These viruses have provided valuable models for studies in cell biology, partic ularly with regard to the cotranslational and posttranslational steps re quired for the synthesis and localization of membrane glycoproteins. Fur thermore, Togaviridae have been pivotal in our growing understanding of how enveloped viruses enter and exit from cells. The broad outlines of the structure and gene expression of Togavir idae and Flaviviridae are known, but important questions remain.
Erscheinungsdatum: 26.11.2012

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nexusstc/The Togaviridae and Flaviviridae/ee04399b1e3004f90ad1f1b88dd38b2b.pdf

zlib/Medicine/James S. Porterfield (auth.), Sondra Schlesinger, Milton J. Schlesinger (eds.)/The Togaviridae and Flaviviridae_2138463.pdf

Springer London, Limited

Springer New York

Plenum Press

Softcover reprint of the original 1st ed. 1986, 2012

United States, United States of America

Springer Nature, New York, NY, 2013

The Viruses Ser, New York, NY, 1986

Viruses, Boston, MA, 1986

lg984537

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Front Matter....Pages i-xv
Comparative and Historical Aspects of the Togaviridae and Flaviviridae....Pages 1-19
Alphavirus Structure....Pages 21-34
Structure and Replication of the Alphavirus Genome....Pages 35-90
Entry of Alphaviruses....Pages 91-119
Formation and Assembly of Alphavirus Glycoproteins....Pages 121-148
Defective RNAs of Alphaviruses....Pages 149-169
Replication of Alphaviruses in Mosquito Cells....Pages 171-207
Alphavirus Pathogenesis and Immunity....Pages 209-249
The Use of Monoclonal Antibodies in Studies of the Structural Proteins of Togaviruses and Flaviviruses....Pages 251-278
Structure of the Flavivirus Genome....Pages 279-326
Replication of Flaviviruses....Pages 327-374
Pathobiology of the Flaviviruses....Pages 375-440
Back Matter....Pages 441-453

2013-08-01