It is not certain that the editors of Antibiotics I (1967), Drs. GOTTLffiB and SHAW, fully realized that they were laying the foundation for an entire series of which we present here Vol. VI. For some time to come, this will be the last volume of the Antibiotics series. There are several reasons for this. Firstly, the discovery of medicinally useful antibiotics has leveled off, because the number of microbiological products with antimicrobial properties is not infinite. In 1972 some 2500 antibiotic substances were known, of which approximately one per cent are clinically useful. Further search for antibiotics has led to increasing frequency of rediscoveries and drasti cally decreasing frequency of discoveries of new antibiotics. As the search for antibiotics with a standard methodology in conventional ecological niches has exhausted itself, there is a paucity of new and interesting substances on which to undertake modes/mechanisms of action studies. Secondly, the mechanism of action field has come of age and its results are now academic knowledge. This also holds true for synthetic chemothera peutic drugs and becomes the case rapidly for toxic substances with anti-eukar yotic action. The study of mechanisms of action was undertaken for two reasons: one was the basic scientific desire to know how antimicrobial substances inter fered with microbial biochemistry; the second one was the hope that such infor mation would be useful in the premeditated design of synthetic antimicrobials.
Erscheinungsdatum: 06.12.2011

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nexusstc/Modes and Mechanisms of Microbial Growth Inhibitors/e37d13f5cd4c9e16e95bafa391baa7c7.pdf

scihub/10.1007/978-3-642-68946-8.pdf

zlib/Medicine/C. H. Hassall (auth.), Professor Fred E. Hahn Ph.D. (eds.)/Modes and Mechanisms of Microbial Growth Inhibitors_2138006.pdf

Spektrum Akademischer Verlag. in Springer-Verlag GmbH

Steinkopff. in Springer-Verlag GmbH

Springer Science & Business Media

Springer-verlag New York, Llc

Springer; Springer-Verlag

Springer London, Limited

Springer Nature, Berlin, Heidelberg, 2012

Antibiotics, 6, Berlin, Heidelberg, 1983

Germany, Germany

Dec 06, 2011

1, 2012

lg984080

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Source title: Modes and Mechanisms of Microbial Growth Inhibitors (Antibiotics (6))

Front Matter....Pages I-X
Alafosfalin (Ro 03-7008, Alaphosphin)....Pages 1-11
Arabinosylcytosine....Pages 12-33
Chloramphenicol....Pages 34-45
Emetine, Cryptopleurine, Tylocrebrine and Other Functionally Related Alkaloids....Pages 46-70
Kirromycin and Related Antibiotics....Pages 71-89
Anti- β -Lactamase Agents....Pages 90-107
Mefloquine....Pages 108-120
Metronidazole....Pages 121-135
Neothramycin....Pages 136-152
Pyrazofurin....Pages 153-160
Ribavirin....Pages 161-186
Rubradirin....Pages 187-198
Silver Sulfadiazine....Pages 199-232
Sporamycin....Pages 233-237
Streptothricin F....Pages 238-247
Novel Inhibitors of Translation in Eukaryotic Systems....Pages 248-254
Tunicamycin and Related Antibiotics....Pages 255-278
Viral Translation Inhibitors....Pages 279-295
Properties of Virginiamycin-like Antibiotics (Synergimycins), Inhibitors Containing Synergistic Components....Pages 296-332
Back Matter....Pages 333-343

2013-08-01