The mouse was first used in immunological research by Paul Ehrlich in 1891 in an extraordinary series of experiments on the maternal transfer of antitoxic immunity. A short 22 years later in 1913 Halsey Bagg acquired a stock of albino mice from a commercial dealer and used them in a series of experiments on learning. Because he was interested in the genetics of intelligence, Halsey Bagg began breeding a pedigreed line of these mice that were subsequently named for him - Bagg Albino. Though Halsey Bagg is not credited with initiating the inbred strains of mice, his stock curiously has played an indisputably important role. Bagg Albinos were progenitors of the present day BALB/c family of sublines - the subject of this book. They were also used as one of the parents in the development of inbred strains A, CBA and C3H, three other very famous strains. Today the BALB/c mouse is among the five most widely used inbred strains in biomedical research and a particular favorite in immunology and infectious disease research. The hallmark of the BALB/c response to so many kinds of infections is susceptibility and sometimes an exaggerated susceptibility, but this paradoxically is not associated with immunodeficiency as BALB/c is an excellent responder to immuni zation. These characteristics have made the BALB/c mouse a model for identifying genes that determine susceptibility to infectious and neoplastic diseases. In 1985 the laboratory BALB/c mouse became 72 years old. The current filial generations are somewhere around 350 generations [MURPHY].
Erscheinungsdatum: 06.12.2011

lgrsnf/A:\Springer\bok%3A978-3-642-70740-7.pdf

nexusstc/The BALB/c Mouse: Genetics and Immunology/e11669677045e0bde1f559243a9e4fc2.pdf

scihub/10.1007/978-3-642-70740-7.pdf

zlib/Medicine/M. Potter (auth.), Michael Potter M.D. (eds.)/The BALB/c Mouse: Genetics and Immunology_2265881.pdf

Michael Potter; National Cancer Institute (U.S.)

A Clarke

Spektrum Akademischer Verlag. in Springer-Verlag GmbH

Brand: Springer; Springer Berlin Heidelberg

Steinkopff. in Springer-Verlag GmbH

Springer London, Limited

Current topics in microbiology and immunology, 122, Berlin, Heidelberg, 1985

Springer Nature, Berlin, Heidelberg, 2012

Germany, Germany

1, 2011-12-06

Dec 06, 2011

sm32939869

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Source title: The BALB/c Mouse: Genetics and Immunology (Current Topics in Microbiology and Immunology)

Front Matter....Pages I-XVI
History of the BALB/c Family....Pages 1-5
Front Matter....Pages 7-7
Some Unusual Genetic Characteristics of BALB/c and Evidence for Genetic Variation Among BALB/c Substrains....Pages 9-18
Genetic Differences in BALB/c Sublines....Pages 19-30
A Series of Recombinant Inbred Strains Between the BALB/cHeA and STS/A Mouse Strains....Pages 31-37
Characteristics of the wm Substrain of BALB/c Mice....Pages 38-42
Qa2 Expression in BALB/c Sublines and a BALB/cLAC Tumor....Pages 43-49
Studies into the raf and Rif Genes in the Mouse....Pages 50-52
Genetic Analysis of Alphafetoprotein Levels in BALB/c Sublines....Pages 53-57
The Origin and Meiotic Instability of a Polymorphic Repetitive Sequence PRI Family....Pages 58-65
Genetic Variation in Catecholamine Responsive Metabolic Pathways — A Hypothesis for a Common Regulatory Mechanism in BALB/c Sublines....Pages 66-70
DNA Hybridization Subtraction: Differences Detected Between BALB/cAnPt and BALB/cJax at the DNA Level....Pages 71-77
Differential Susceptibility of BALB/c Sublines to Diabetes Induction by Multi-Dose Streptozotocin Treatment....Pages 78-85
Genetically Contaminated BALB/c Nude Mice....Pages 86-88
The Genetic Stability of Endogenous Type B and C Retroviruses in BALB/c Sublines....Pages 89-94
Front Matter....Pages 95-95
Response of BALB/c Mice to Leishmanial Infection....Pages 97-106
Immunoprophylaxis in BALB/c Mice: A Model for Development of Protection Against Primary and Secondary Infection with Leishmania major ....Pages 107-114
Genetic Control of Systemic Leishmania major Infection: Identification of Subline Differences for Susceptibility to Disease....Pages 115-121
Role of T Cells in the Unusual Cutaneous Responses to Leishmania in BALB/c Mice....Pages 122-127
Susceptibility of BALB/c Sublines to Infection with Listeria Monocytogenes ....Pages 128-133
Genetic Control of the Macrophage Inflammatory Response Elicited in a Subcutaneous Site....Pages 134-137
Front Matter....Pages 95-95
Interaction of Nocardia asteroides in BALB/c Mice: Modulation of Macrophage Function, Enzyme Activity and the Induction of Immunologically Specific T-Cell Bactericidal Activity....Pages 138-147
The BALB/c Mouse as a Model to Study Orthopoxviruses....Pages 148-153
Genetic Control of Multisystem Autoimmune Disease in Encephalomyocarditis Virus Infected BALB/cCUM and BALB/cBYJ Mice....Pages 154-161
Susceptibility to Abelson or Moloney Murine Leukemia Viruses....Pages 162-168
Front Matter....Pages 169-169
Immunological Tolerance in BALB/c Mice....Pages 171-175
The Tol-1 Gene in BALB/c Mice....Pages 176-180
Differential Susceptibility to Experimental Autoimmune Orchitis in BALB/c Substrains....Pages 181-188
Variation in Responsiveness of BALB/c Sublines and Congenic Mice to Phase I Coxiella burnetii Infection and Vaccination....Pages 189-199
Isotype-Specific Interactions Between Regulatory T Cells and Secreted and Membrane-Bound Monoclonal Immunoglobulins....Pages 200-204
Genetic Control of Inununoglobulin Isotype Restriction....Pages 205-209
Front Matter....Pages 211-211
Pristane-Induced Arthritis in BALB/c Mice....Pages 213-220
Response of the Peritoneal Mesothelium to the Mineral Oil, Pristane....Pages 221-233
BALB/c Subline Differences in Susceptibility to Plasmacytoma Induction....Pages 234-241
Differences in the Peritoneal Response to Pristane in BALB/cAnPt and BALB/cJ Mice....Pages 242-253

2013-12-12