This volume contains the Proceedings of the invited lectures of the Second International Sym­ posium on SEROTONIN from Cell Biology to Pharmacology and Therapeutics held in Houston, Texas September 15-18, 1992. The meeting was held under the co-sponsorship of the Serotonin Club, the Giovanni Lorenzini Medical Foundation, and the Fondazione Giovanni Lorenzini. This volume discusses the major exploration in knowledge that has occurred recently of the complex role that 5- hydroxytryptamine (serotonin) plays in health and disease. In par­ ticular, these Proceedings highlight major breakthroughs in molecular biology and classification of receptor subtypes that are responsible for the many actions of the monoamine. The ever­ increasing importance of serotonin in central regulation, whether autonomic or behavioral is represented by a large number of chapters prepared by world experts. Additionally, the role of serotonin in peripheral organs is also discussed. Hence, this volume provides the reader with a unique, up-to-date review of this exciting and novel area of science. These Proceedings obviously are of great interest, not only to the researchers directly engaged in the quest for the understanding and unraveling of the actions of the interactions with serotonin as a major neurohumoral mediator, but also to all scholars and clinicians who wish to acquire a better understanding of the functioning of the brain and of peripheral organs. Since this volume was constructed as a compilation of invited lectures, the scientific content and the opinions expressed in the chapters are the sole responsibility of the authors.

lgrsnf/A:\Springer\bok%3A978-94-011-1920-7.pdf

nexusstc/Serotonin: From Cell Biology to Pharmacology and Therapeutics/dce63385621a729f735d59f742462211.pdf

zlib/Medicine/Jean C. Shih, Qin-Shi Zhu, Joseph Grimsby, Kevin Chen, Jack Shih (auth.), P. M. Vanhoutte, P. R. Saxena, R. Paoletti, N. Brunello, A. S. Jackson (eds.)/Serotonin: From Cell Biology to Pharmacology and Therapeutics_2242187.pdf

Rodolfo Paoletti; International Symposium on "Serotonin: from Cell Biology to Pharmacology and Therapeutics"

Paul M Vanhoutte; International Symposium on "Serotonin: from Cell Biology to Pharmacology and Therapeutics"

Editor-paul M. Vanhoutte; Editor-rodolfo Paoletti; Editor-nicoletta Brunello; Editor-franco M. Maggi

Paul M. Vanhoutte, Ann S. Jackson, P. R. Saxena, Rodolfo Paoletti, Nicoletta Brunello

Paul M. Vanhoutte; P.R. Saxena; Rodolfo Paoletti; Nicoletta Brunello; Ann S. Jackson

Rodolfo Paoletti; Paul M Vanhoutte; Nicoletta Brunello; Franco M Maggi

edited by Rodolfo Paoletti ... [et al.]

Kluwer Academic Publishers ; Sold and distributed in the U.S.A. and Canada by Kluwer Academic Publishers

Kluwer Academic Publishers ; Fondazione Giovanni Lorenzini ; Giovanni Lorenzini Medical Foundation

Springer Science + Business Media BV

Paul M Vanhoutte; Springer

Medical science symposia series, v. 5, Dordrecht, Boston, Milan, Italy, ©1993

Softcover reprint of the original 1st ed. 1993, 2012

Dordrecht, Boston, Norwell, MA, Netherlands, 1990

United States, United States of America

Springer Nature, Dordrecht, 2012

1 edition, December 31, 1989

Netherlands, Netherlands

Oct 23, 2012

1990, 1989

lg1073221

{"container_title":"Medical Science Symposia Series","edition":"1","isbns":["0792305310","9401048495","9401119201","9780792305316","9789401048491","9789401119207"],"issns":["0928-9550"],"last_page":435,"publisher":"Springer Netherlands","series":"Medical Science Symposia Series 5"}

Includes bibliographical references.
"Proceedings of the invited lectures of the First International Symposium on "Serotonin from Cell Biology to Pharmacology and Therapeutics" which was held in Florence on March 29-April 1, 1989"--Pref.
Includes index.

Source title: Serotonin (Medical Science Symposia Series)

Front Matter....Pages i-xii
Different Organization of Human Monoamine Oxidase (Mao) A and B Promoters....Pages 1-8
Molecular Biology of Serotonin Uptake Sites....Pages 9-19
Molecular biology of 5-HT, receptors....Pages 21-31
5-HT 1b/D „-Receptor Agonists Block C-Fos-Li Within Trigeminal Nucleus Caudalis in Response to Noxious Meningeal Stimulation....Pages 33-39
A Reappraisal of 5-HT Receptor Classification....Pages 41-47
Classification of Agents Used in Serotonin Research....Pages 49-54
Electrophysiology of Central Serotonin Neurotransmission....Pages 55-63
Immunohistochemical Visualization of 5-HT 1A Receptors in the Rat Brain....Pages 65-71
In Vitro Functional Correlates Of 5-HT,-Like Receptors....Pages 73-84
5-HT 1D Receptor Subtypes....Pages 85-97
5-HT 3 Receptors....Pages 99-106
5-HT 4 Receptor: Current Status....Pages 107-117
Serotonergic Receptors: from Ligands to Sequence....Pages 119-126
Possible Mechanisms of Action of Drugs Effective Against Acute Migraine Attacks....Pages 127-133
SB 203186, A Potent 5-HT4 Antagonist for Cardiac 5-HT4 Receptors....Pages 135-139
Role of the Lateral Tegmental Field in the Sympatholytic Action of 5-HT1A Agonists....Pages 141-149
Urapidil: The Role of 5-HT 1A and α-Adrenergic Receptors in Blood Pressure Reduction....Pages 151-157
Clinical Aspects of Antiemesis: Role of the 5-HT, Antagonist s ....Pages 159-164
The Antiemetic Properties of 5-HT 3 Receptor Antagonists....Pages 165-170
Mechanisms of the Emetic Response to Chemotherapy and of the Antiemetic Action of 5-HT 3 Receptor Antagonists: Clinical Studies....Pages 171-178
Serotonin and Serotonergic Drugs in Emesis....Pages 179-186
Clinical Effects of 5-HT, Antagonists in Treating Nausea and Vomiting....Pages 187-196
Inhibitors of Serotonin Uptake....Pages 197-204
Preclinical Evidence for the Role of Serotonin Receptors in Anxiety....Pages 205-210
The Effects of Tryptophan Depletion in Depression....Pages 211-222
Anxiolytic Effects of Drugs Acting on 5-HT Receptor Subtypes....Pages 223-230
Obsessive Compulsive Disorders: A Neurobiological Hypothesis....Pages 231-237
Role of the Serotonergic System in Pituitary Hormone Secretion: The Pharmacologic Challenge Paradigm in Man....Pages 239-247
Serotonin in Anxiety and Related Disorders....Pages 249-254
Alcoholic Violent Offenders: Behavioral, Endocrine, Diurnal Rhythm, and Genetic Correlates of Low Csf 5-Hiaa Concentrations....Pages 255-261
Modulation of Dopaminergic Neurotransmission by 5-HT 2 Antagonism....Pages 263-270
Combined Serotonin 5-HT 2 and Dopamine Da 2 Antagonist Treatments in Chronic Schizophrenia....Pages 271-276
Is Serotonin Involved in the Pathogenesis of Schizophrenia?....Pages 277-288
Serotonin Antagonists as Antipsychotics....Pages 289-296
Pharmacological Analysis of 5-HT Receptors in Human Small Coronary Arteries....Pages 297-305
Platelets, Platelet Mediators, and Unstable Coronary Artery Disease Syndromes....Pages 307-319
Abnormal Coronary Vasoconstrictor Responses to Serotonin in Patients with Ischemic Heart Disease....Pages 321-328
5-HT And The Immune System....Pages 329-335
The Stimulatory Effects of D-Fenfluramine (D-Fen) on Blood and Splenic Immune Functions in the Fischer 344 Rat Are Age and Sex Dependent....Pages 337-343
Serotonergic Regulation of Natural Killer Cells: A Minireview....Pages 345-351
Interactions Between Serotonin and the Immune System: an Overview....Pages 353-357
The Role of Serotonin in the Cellular Physiological Effects of Cocaine....Pages 359-365
Serotonin Mechanisms in Ethanol Abuse....Pages 367-374
Serotonin Regulation of Alcohol Drinking....Pages 375-381
Hypothalamic Serotonin in Relation to Appetite for Macronutrients and Eating Disorders....Pages 383-391
Serotonergic Pharmacology of Appetite....Pages 393-399
Serotonin (5-HT) 1A Receptor Agonists and Neuroprotection....Pages 401-405
New Antidementia Molecules Which Selectively Influence Serotonin Receptor Subtypes....Pages 407-416
Pharmacological Modulation of the Serotonergic System: an Overview of the Effects on Normal and Pathological Sleep....Pages 417-424
Back Matter....Pages 425-435

This volume represents the proceedings ofthe invited lectures ofthe first International Symposium on'Serotonin from Cell Biology to Pharmacology and Therapeutics'which was held in Florence on March 29 -Aprill, 1989. This meeting, held under the co-sponsorship of the Serotonin Club and the Fondazione Giovanni Lorenzini, represents the first attempt to bring together scientists fascinated by the complexity of the action of 5-hydroxytryptamine throughout the body and in various species. Hence this volume provides the reader with the unique overview of the sources, effects, receptors, physiological actions and pathological role of Serotonin. As such it will be of interest not only to the person devoting herorhis research efforts to the study of 5-hydroxytryptamine but also to all scholars and even clinicians wanting to know how the powerful monoamine can modulate cellular functions. To accelerate the publication of these proceedings the Editors and the publishers have selected the camera ready format and have avoided a lengthy refereeing process. Hence the scientific content of, and the opinions expressed in the chapters are the sole responsibility of the authors. The Editors Milan and Houston The Editors want to thank Mrs. H. Liepman and her staff at Kluwer for the prompt and efficient handling of the manuscripts.

<p>This volume represents the proceedings of the invited lectures of the second International Symposium on Serotonin from Cell Biology to Pharmacology and Therapeutics, which was held in Houston, September 1992, under the co-sponsorship of the Serotonin Club, Baylor College of Medicine, the Giovanni Lorenzini Medical Foundation (Houston), and the Fondazione Giovanni Lorenzini (Milan). The symposium brought together pharmacologists, physiologists, molecular biologists, and clinical scientists working in the complex field of serotonin. Hence this volume provides the reader with a unique overview of the sources, effects, receptors, molecular biology, physiological actions and pathological roles of serotonin agonists and antagonists. As such the book will be of interest both to persons devoting their research efforts to serotonin as well as to all scholars and clinicians wanting to know how this powerful monoamine can modulate cellular functions. <br/></p>

This volume represents the proceedings ofthe invited lectures ofthe first International Symposium on "Serotonin from Cell Biology to Pharmacology and Therapeutics" which was held in Florence on March 29 -Aprill, 1989.

2013-12-12