For the clinician the sinus node is more or less a hidden structure and only by indirect assessment he is able to say something about the function of this center of pacemaker activity. The morphologist, however, is able to describe the structural microscopic and even electronmicroscopic features of this structure. The only disadvantage is that, as soon as he is coming into the picture, the tissue is dead. The physiologist tries to investigate the electrophysiological behavior of the sinus node. Since there is not a human being willing to give his sinus node for research, he has to do his investigation on isolated preparations of animals. Though there are a lot of experts in the field of the sinus node they nearly never speak the same 'language'. Therefore, it was my dream to bring all those people - or at least some of them -together on a workshop. I had the feeling that it was important to organize such a meeting without an audience but only with 'experts'.
Erscheinungsdatum: 13.10.2011

lgrsnf/A:\Springer\bok%3A978-94-009-9715-8.pdf

nexusstc/The Sinus Node/dc66935e127d0c84b6a3750938126e15.pdf

zlib/Medicine/Jay L. Jordan, Iwao Yamaguchi, William J. Mandel (auth.), Felix I. M. Bonke (eds.)/The Sinus Node: Structure, Function, and Clinical Relevance_2240779.pdf

Workshop on Sinus Node

Springer Science + Business Media BV

Springer London, Limited

Nijhoff Medical Division

Springer Nature, Dordrecht, 2012

Netherlands, Netherlands

The Hague, 1978

Dordrecht, 1978

2011

lg1071813

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Front Matter....Pages I-XII
Front Matter....Pages 1-1
Function and Dysfunction of the Sinus Node: Clinical Studies in the Evaluation of Sinus Node Function....Pages 3-22
Measurement of Sinus Node Recovery Time After Atrial Pacing....Pages 23-35
Programmed Atrial Stimulation Used for the Calculation of Sinoatrial Conduction Time (SACT) in Man....Pages 36-45
The Pattern of the First and Second Return Cycle After Premature Atrial Stimulation....Pages 46-55
Programmed Atrial Stimulation and Rapid Atrial Pacing in Patients with Sinus Pauses and Sinoatrial Exit Block....Pages 56-64
A New Technique for Measurement of Sinoatrial Conduction Time....Pages 65-76
Relevance of Diagnostic Atrial Stimulation for Pacemaker Treatment in Sinoatrial Disease....Pages 77-88
The Response of the Sinus Node to Premature Stimulation of the Atrium Studied with Microelectrodes in Isolated Atrial Preparations of the Rabbit Heart....Pages 89-102
Review of the Significance of Drugs in the Sick Sinus Node Syndrome....Pages 103-111
Effect of Propranolol on Normal and Abnormal Sinus Node Function....Pages 112-128
Dual Effect of Verapamil on Sinus Node Function in Man....Pages 129-138
General Conclusions: Limitations of Sinus Node Function Testing in Patients with Known or Suspected Sinus Node Disease....Pages 139-146
Front Matter....Pages 147-147
The Fine Structure of the Sinus Node: a Survey....Pages 149-165
The Development of the Sinoatrial Node....Pages 166-182
Techniques and Problems in Correlating Cellular Electrophysiology and Morphology in Cardiac Nodal Tissues....Pages 183-194
Ultrastructural and Functional Aspects of the Rabbit Sinoatrial Node....Pages 195-211
General Comments....Pages 212-222
Front Matter....Pages 223-223
A General Introduction About the Current Status of the Electrophysiology of the Sinus Node....Pages 225-232
Characterization of a Two-Component Upstroke in the Sinus Node Subsidiary Pacemaker....Pages 233-244
Pacemaker Shifts in the Sinus Node: Effects of Vagal Stimulation, Temperature and Reduction of Extracellular Calcium....Pages 245-257
Front Matter....Pages 223-223
Cardiac Glycosides and Pacemaker Activity of the Sinus Node — A Microelectrode Study on the Isolated Right Atrium of the Rabbit....Pages 258-269
Effects of Polarization and of Inhibitors of Ionic Conductances on the Action Potentials of Nodal and Perinodal Fibers in Rabbit Sinoatrial Node....Pages 270-278
The Accelatory Action of the Vagus on the Sinus Node....Pages 279-289
General Conclusions....Pages 290-298
Front Matter....Pages 299-299
Ionic Currents in Rabbit Sinoatrial Node Cells....Pages 301-310
Fine Structure of the Small Sinoatrial Node Specimen Used for the Voltage Clamp Experiment....Pages 311-319
Membrane Currents Underlying Rhythmic Activity in Frog Sinus Venosus....Pages 320-332
Involvement of the Chloride Ions in the Membrane Currents Underlying Pacemaking Activity in Frog Atrial Trabeculae....Pages 333-338
Which Ions are Important for the Maintenance of the Resting Membrane Potential of the Cells of the Sinotrial Node of the Rabbit?....Pages 339-347
Does Spontaneous Activity Arise from Phase 4 Depolarization or from Triggering?....Pages 348-356
On the Possible Mechanism Underlying Spontaneous Pacemaking....Pages 357-367
General Comments: Ionic Currents Underlying Spontaneous Rhythm of the Cardiac Primary Pacemaker Cells....Pages 368-375
Front Matter....Pages 377-377
Clinical Evidence for Sinus Node Reentry....Pages 379-388
Sequence of Atrial Activation in Patients with Atrial Echo Beats....Pages 389-408
Re-Entry within the Sinoatrial Node as Demonstrated by Multiple Micro-Electrode Recordings in the Isolated Rabbit Heart....Pages 409-421
Role of Sinus Node Re-Entry in the Genesis of Sustained Cardiac Arrhythmias....Pages 422-427
General Conclusions....Pages 428-428
Back Matter....Pages 429-459

2013-12-12