The peptide hormones are small proteins that regulate cellular metabolism through their specific interactions with tissues of the endocrine, nervous, and immune systems, as well as in embry­ onic development. During the past ten years, refinements in the techniques of recombinant DNA technology have resulted in the cloning of genes encoding approximately 50 different hormonal and regulatory peptides, including those in which the peptides themselves and the mRNAs encoding the peptides are present in only trace amounts in the tissues of origin. In addition to provid­ ing the coding sequences of recognized hormonal and regulatory peptides, gene sequencing has uncovered new bioactive peptides encoded in the precursor pro hormones that are then liberated along with the hormonal peptides during cellular cleavages of the precursors. The encoding of multiple peptides in a single mono­ cistronic mRNA appears to be a genetic mechanism for the gener­ ation of biologic diversification without requiring amplification of gene sequences. Two of the objectives in the assembly of this book are to pre­ sent, in one volume, the known primary structures of the genes encoding several of the polypeptide hormones and related regulatory peptides, and to provide an account of the various ap­ proaches that have been used to identify and select the cloned genes encoding these polypeptides. The contents of the two in­ troductory chapters are intended to provide the reader with a brief background of the approaches to gene cloning and the struc­ ture and expression of hormone-encoding genes.

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nexusstc/Molecular Cloning of Hormone Genes/d27a225464f5af1fe24c9b980efd9839.pdf

scihub/10.1007/978-1-4612-4824-8.pdf

zlib/Biology and other natural sciences/Joel F. Habener (auth.), Joel F. Habener (eds.)/Molecular Cloning of Hormone Genes_2138717.pdf

Springer

Molecular biology and biophysics, Clifton, N.J, ©1987

Softcover reprint of the original 1st ed. 1987, 2011

United States, United States of America

Springer Nature, Totowa, NJ, 2012

sm42088029

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Front Matter....Pages i-xvii
Approaches to Gene Cloning....Pages 1-9
Gene Structure and Regulation....Pages 11-51
Insulin Genes....Pages 53-68
The Glucagon Genes....Pages 69-92
The Somatostatin Genes....Pages 93-119
The Human Growth-Hormone Gene Family....Pages 121-135
Glycoprotein Hormone Genes....Pages 137-172
Oxytocin and Vasopressin Genes....Pages 173-206
The Proopiomelanocortin Genes....Pages 207-228
Enkephalin Genes....Pages 229-276
Calcitonin and Calcitonin-Related Peptide Genes....Pages 277-301
Parathyroid Hormone Genes....Pages 303-319
The Renin Gene....Pages 321-342
Nerve Growth Factor....Pages 343-363
Bombesin-Like Peptide Genes....Pages 365-390
Biosynthesis of Peptides in the Skin of Xenopus laevis ....Pages 391-404
cDNA Encoding Precursors of the Bee-Venom Peptides Melittin and Secapin....Pages 405-412
Yeast α-Factor Genes....Pages 413-434
Back Matter....Pages 435-441

2013-08-01