Since 1952, postgraduate courses for practising physicians and speci alists have been given by the Medical Faculty of the University of Leiden in the Boerhaave Quarter, in which most of its clinics and laboratories are located. During these years, recent advances in a wide variety of m~dical fields and subjects have been discussed by distin guished speakers from many countries. The steadily increasing atten dance has shown that, as could be expected from the rapid progress of modern medicine, there is a widely felt need for this form of postgra duate study. In 1957, therefore, the Leiden Medical Faculty appointed a permanent committee for the organization of postgraduate medical education. Of the courses given since then, certain material proved to have sufficient immediate scientific value to justify publication, and it now gives the Committee great pleasure to announce that in collaboration with the Leiden University Press it will publish the Boerhaave Series for Postgraduate Medical Education. The first volume of this new series is the product of the course on Human Blood Coagulation given in Novem ber 1968. It is our hope that this book will prove valuable not only to those who participated in the course but also to many others working in this and associated fields.
Erscheinungsdatum: 05.11.2011

lgrsnf/A:\Springer\bok%3A978-94-010-3423-4.pdf

nexusstc/Human Blood Coagulation: Biochemistry, Clinical Investigation and Therapy/c9f23d0bdcfc9616ca78fa0daf6b39c6.pdf

zlib/Medicine/H. C. Hemker M.D., E. A. Loeliger M.D., J. J. Veltkamp M.D. (auth.), H. C. Hemker M.D., E. A. Loeliger M.D., J. J. Veltkamp M.D. (eds.)/Human Blood Coagulation: Biochemistry, Clinical Investigation and Therapy_2241708.pdf

H. C. Hemker, E. A. Loelinger, J. J. Veltkamp

Springer Science + Business Media BV

Boerhaave Series for Postgraduate Medical Education, Proceedings of the Boerhaave Courses Organized by the Faculty of Medicine, University of Leiden, The Netherlands, 1, Dordrecht, 1969

Springer Nature, Dordrecht, 2012

Netherlands, Netherlands

2011

lg1072742

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Front Matter....Pages I-XV
Blood Coagulation in Medicine and Biochemistry....Pages 1-3
Back Matter....Pages 117-140
Front Matter....Pages 5-5
The Formation of the Fibrin Clot from Fibrinogen....Pages 7-12
Discussion....Pages 13-17
On the Structure of Thrombin and Prothrombin....Pages 18-21
Discussion....Pages 22-23
The Interactions of Prothrombin and Factors V and X with Phospholipids and Calcium Ions....Pages 24-36
Discussion....Pages 37-39
The Nature of Prothrombinase....Pages 40-44
Discussion....Pages 45-47
The Interaction of Factors VIII, IX, and X....Pages 48-53
Discussion....Pages 54-57
The Nature of the Factor IX Activating Principle....Pages 58-72
Discussion....Pages 73-76
The Possible Role of Factor VII in the Intrinsic System....Pages 77-81
Discussion....Pages 82-82
Factor VII and Tissue Thromboplastin....Pages 83-88
Discussion....Pages 89-93
Enzyme Systems Triggered by the Contact Factors....Pages 94-98
Discussion....Pages 99-103
Enzyme Kinetic Evaluation of Coagulation Systems....Pages 104-110
Front Matter....Pages 5-5
Discussion....Pages 111-116
Front Matter....Pages 141-141
The Mechanism of Haemostasis....Pages 143-146
Morphology of the Process of Haemostasis....Pages 147-149
Indication, Assay Procedures, Diagnosis, and Advice....Pages 152-221
The Role of Fibrinogen and Fibrin Degradation Products in the Blood....Pages 224-227
Quantification of Split Products....Pages 228-233
General Considerations Concerning Treatment of Haemorrghaic Diathesis....Pages 236-241
Platelet Transfusion in Patients with Platelet ISO-Antibodies....Pages 242-250
Purification and Clinical Application of the Four Factors of the Prothrombin Complex....Pages 251-256
Four-Clotting-Factor Concentrate....Pages 257-259
Preparation and Clinical Application of Cryoprecipitate....Pages 260-269
Some Remarks Concerning the Production and Administration of Cryoprecipitates....Pages 270-273
Genetic Counselling in Haemostatic Disorders....Pages 274-279
Front Matter....Pages 281-281
General Considerations on a Coumarin-Induced Hypocoagulability and Its Control....Pages 283-285
The Netherlands Thrombosis Service....Pages 286-287
The Manchester Comparative Reagent....Pages 290-295
Discussion....Pages 296-297
The History of Thrombotest....Pages 300-308
Quality Control of Thrombotest (TT) and Normotest (NT)....Pages 309-313
Introduction of Thrombotest at the Netherlands Thrombosis Services....Pages 314-317
Front Matter....Pages 281-281
Introduction of Thrombotest at the Amsterdam Thrombosis Service....Pages 318-319
Thrombotest Versus Conventional Thromboplastins....Pages 320-324
Discussion....Pages 325-327
Thrombotest Levels in Relation to Recurrences and Bleeding Complications in Long-Term Treatment of Patients Suffering from Coronary Heart Disease....Pages 330-335
The Utrecht Double Blind Trial of Long -Term Anticoagulant Treatment after Myocardial Infarction....Pages 336-338
The Leiden Double-Blind Trial of Long-Term Anticoagulant Treatment After Myocardial Infarction....Pages 339-341
Discussion....Pages 342-344
Vitamin K 1 Therapy....Pages 345-357
Front Matter....Pages 359-359
Blood Coagulation and Liver Function....Pages 361-364
The Thrombotest Dilution Curve and Its Diagnostic Significance....Pages 365-368
Normotest in the Evaluation of Liver Function....Pages 369-378
Clinical Experience with Normotest....Pages 379-380
Preliminary Experience with Normotest....Pages 381-385
Discussion....Pages 386-388
Back Matter....Pages 389-397

2013-12-12