"This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells' strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers."--Résumé de l'éditeur

lgrsnf/K:/!genesis/spr/10.1007%2F978-981-10-6955-0.pdf

nexusstc/DNA Replication/b4a7a06d6bd93cbf76c4d5606eef99a9.pdf

zlib/Biology and other natural sciences/Genetics/Hisao Masai, Marco Foiani, (eds.)/DNA Replication: From Old Principles to New Discoveries_3422265.pdf

Erma Z. Drobnis; Ajay K. Nangia

Masai, Hisao; Foiani, Marco

Springer Science + Business Media Singapore Pte Ltd

Springer Nature Singapore

Advances in experimental medicine and biology (Print), Springer, 2017

Advances in experimental medicine and biology, 1042, Singapore, 2017

Advances in Experimental Medicine and Biology, 2018

Springer Nature, Singapore, 2017

Singapore, Singapore

Jan 31, 2018

2, 20180122

0

lg2180945

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Source title: DNA Replication: From Old Principles to New Discoveries (Advances in Experimental Medicine and Biology (1042))

Front Matter ....Pages i-xii
Historical Perspective of Eukaryotic DNA Replication (Thomas Kelly)....Pages 1-41
Regulation of Replication Origins (Anna B. Marks, Haiqing Fu, Mirit I. Aladjem)....Pages 43-59
Molecular Mechanism for Chromatin Regulation During MCM Loading in Mammalian Cells (Nozomi Sugimoto, Masatoshi Fujita)....Pages 61-78
Initiation of DNA Replication at the Chromosomal Origin of E. coli, oriC (Tsutomu Katayama)....Pages 79-98
Initiation of DNA Replication in the Archaea (Stephen D. Bell)....Pages 99-115
Mechanism of Lagging-Strand DNA Replication in Eukaryotes (Joseph L. Stodola, Peter M. Burgers)....Pages 117-133
Functions of Multiple Clamp and Clamp-Loader Complexes in Eukaryotic DNA Replication (Eiji Ohashi, Toshiki Tsurimoto)....Pages 135-162
Termination of Eukaryotic Replication Forks (Agnieszka Gambus)....Pages 163-187
Structure of the MCM2-7 Double Hexamer and Its Implications for the Mechanistic Functions of the Mcm2-7 Complex (Yuanliang Zhai, Bik-Kwoon Tye)....Pages 189-205
Architecture of the Saccharomyces cerevisiae Replisome (Lin Bai, Zuanning Yuan, Jingchuan Sun, Roxana Georgescu, Michael E. O’Donnell, Huilin Li)....Pages 207-228
Replication Domains: Genome Compartmentalization into Functional Replication Units (Peiyao A. Zhao, Juan Carlos Rivera-Mulia, David M. Gilbert)....Pages 229-257
Rif1-Dependent Regulation of Genome Replication in Mammals (Sara B. C. Buonomo)....Pages 259-272
G-Quadruplexes and DNA Replication Origins (Marie-Noëlle Prioleau)....Pages 273-286
Interaction of Rif1 Protein with G-Quadruplex in Control of Chromosome Transactions (Kenji Moriyama, Mong Sing Lai, Hisao Masai)....Pages 287-310
Chromatin Replication and Histone Dynamics (Constance Alabert, Zuzana Jasencakova, Anja Groth)....Pages 311-333
The Temporal Regulation of S Phase Proteins During G1 (Gavin D. Grant, Jeanette G. Cook)....Pages 335-369
Roles of SUMO in Replication Initiation, Progression, and Termination (Lei Wei, Xiaolan Zhao)....Pages 371-393
The Multiple Roles of Ubiquitylation in Regulating Challenged DNA Replication (Sara Villa-Hernández, Avelino Bueno, Rodrigo Bermejo)....Pages 395-419
Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System (Tarek Abbas, Anindya Dutta)....Pages 421-454
Coordinating Replication with Transcription (Yathish Jagadheesh Achar, Marco Foiani)....Pages 455-487
Fragility Extraordinaire: Unsolved Mysteries of Chromosome Fragile Sites (Wenyi Feng, Arijita Chakraborty)....Pages 489-526
Cyclin E Deregulation and Genomic Instability (Leonardo K. Teixeira, Steven I. Reed)....Pages 527-547
Replication Through Repetitive DNA Elements and Their Role in Human Diseases (Advaitha Madireddy, Jeannine Gerhardt)....Pages 549-581

"This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells' strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers."--Résumé de l'éditeur

2018-02-03