The most common cause of death in the civilized countries remains coronary heart dis­ ease, a multifactorial illness which might be best treatable by prophylactic means. In spite of improvements in diagnosis, drug therapy, monitoring, and particularly surgery morbi­ dity and mortality of our patients oblige us to look for new frontiers in understanding the pathophysiology of the disease and for new approaches in the treatment of myocardial dysfunction, the limiting factor in the activity of patients surviving an acute myocardial infarction. Salvage of viable myocardium still seems to be the most important challenge in the treatment of acute ischemia. Lysis therapy to reopen occluded coronary arteries seems to be promising in a great number of patients. However, several experimental re­ ports of reperfusion injury and clinical series with a considerable number of patients, who do not benefit from this intervention, need alternatives to reassess myocardial structure and function. The necessity to find solutions to this problem coincides with the develop­ ment of an alternate access route to deprived coronary vasculature. Starting with the ideas and results gathered in the last 60 years, Meerbaum and Corday in Los Angeles and our group here in Vienna developed two different approaches to myocardial protection via the coronary sinus.

lgli/10.1007%2F978-3-642-54127-8.pdf

lgrsnf/10.1007%2F978-3-642-54127-8.pdf

zlib/Medicine/M. v. Lüdinghausen, E. Ratajczyk-Pakalska, M. Tschabitscher, G. Maurer, D. Glogar (auth.), W. Mohl M.D., E. Wolner M.D., D. H. Glogar M.D. (eds.)/The Coronary Sinus: Proceedings of the 1st International Symposium on Myocardial Protection via the Coronary Sinus_2090248.pdf

International Symposium on Myocardial Protection via the Coronary Sinus

Spektrum Akademischer Verlag. in Springer-Verlag GmbH

Steinkopff. in Springer-Verlag GmbH

Heidelberg, 1984

Germany, Germany

Berlin, 1984

lg936361

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Content:
Front Matter....Pages I-XII
Nomenclature: Venae cardiacae — cardiac veins....Pages 1-4
Anatomy of the Coronary Arteries and Veins....Pages 5-7
Anatomy of Coronary Veins....Pages 8-25
The Microcirculatory Vascular Bed of the Dog’s Heart. A Scanning Electron Microscopy Study of Vascular Corrosion Casts....Pages 26-32
Automated Image Analysis for Measurement of Area of the Smallest Cardiac Veins in Ventricular Myocardium....Pages 33-39
Anatomical Basis for the Coronary Venous Outflow....Pages 40-46
The Vascularization Pattern in the Ventricular Wall in Different Species During Development....Pages 47-52
Functional Anatomy of the Coronary Sinusoids....Pages 53-59
Wave Reflections and Pressure Flow Relations in the Coronary Circulation....Pages 60-72
Fluid Dynamics in Proximal and Distal Coronary Artery Measured by Laser Doppler Velocimeter....Pages 73-78
Dynamic Characteristics of Diastolic Pressure — Flow Relation in the Canine Coronary Artery....Pages 79-85
Coronary Fluid Dynamics....Pages 86-91
Determinants of Cardiac Pump Efficiency. Comparison of a Theoretical Model With Experimental Data of Normo- and Hypothermic Dogs....Pages 92-99
Origin of Phasic Coronary Venous Flow and the Capacitance of Intramyocardial Coronary Vein....Pages 100-105
Determination of Myocardial Blood Flow with Transcoronary Dye Dilution....Pages 106-112
Diastolic Distribution of Intramural Pressure in the Canine Left Ventricle....Pages 113-117
Is Intramyocardial Pressure Measurable?....Pages 118-124
Cardiodynamics Governed by Intramyocardial Hydraulics....Pages 125-133
Purine Metabolism of the Heart....Pages 134-141
Sustained Anaerobic Metabolism After Recanalization of Coronary Artery in Acute Myocardial Infarction....Pages 142-147
Failure of Postischemic ATP Repletion by Adenosine to Improve Regional Myocardial Function....Pages 148-152
Metabolic Changes of Glucose, Lactate and Free Fatty Acids During Ischemia and Subsequent Reperfusion....Pages 153-159
Oxygen-Debt and -Repayment in the Early Phase of Myocardial Ischemia....Pages 160-166
Penetration of Coronary Venous Injections into Ischemic Myocardium....Pages 167-175
The Evaluation of Collateral Function by Contrast Medium-Induced Hyperemia....Pages 176-181
Quantitative Assessment of Collateral Flow in Patients with Ischemic Heart Disease....Pages 182-187
Left Main Coronary Artery Stenosis: Evaluation by Coronary Sinus Blood Flow, Lactate Metabolism and Holter Monitoring....Pages 188-193
Myocardial Protection, Complex Laboratory Examinations and their Computerized Evaluation....Pages 194-201
Acute Myocardial Ischemic Reduction with Ibuprofen in the Isolated Perfused Rabbit Heart....Pages 202-211
Effect of Dipyridamole on Coronary Flow: A Thermodilution Study of the Coronary Reserve....Pages 212-220
Coronary Blood Flow Modifications After Administration of Captopril....Pages 221-226
Cold Pressor Test, Incremental Cardiac Pacing, Coronary Hemodynamics and Coronary Sinus Blood Rheology in Patients with Angina Pectoris and Normal Coronary Angiogram....Pages 227-230
Hemodynamic Pattern of Cardiodepression Elicitable from Reflexogenic Areas in Left Coronary Venous System of the Dog....Pages 231-238
Present Knowledge of the Effects of Experimental Cardiac Lymphatic Obstruction....Pages 239-246
An Overview of Myocardial Protection in Open-heart Surgery....Pages 247-258
Cardiac Prostacyclin Metabolism During Canine Cardiopulmonary Bypass....Pages 259-265
Thermographic Evaluation of Retrograde Cardioplegia: Experimental and Clinical Studies....Pages 266-269
Myocardial Compliance Following Retrograde Versus Antegrade Cardioplegia in the Presence of Coronary Artery Obstruction....Pages 270-274
Cold Cardioplegia via Retrograde Coronary Sinus Infusion for Myocardial Protection....Pages 275-283
Metabolic and Ultrastructural Changes in the Ischemic Human Myocardium due to Additional Perfusion of the Coronary Sinus with “Bretschneider Cardioplegic Solution”....Pages 284-290
Pressure Controlled Intermittent Coronary Sinus Occlusion — an Alternative to Retrograde Perfusion of Arterial Blood....Pages 418-423
Myocardial Equilibration Aspects of Ante- and Retrograde Crystalloid Cardioplegic Perfusion....Pages 291-296
Coronary Venous Blood Parameters During Postischemic Reperfusion After Mitral Valve Replacement....Pages 297-304
Myocardial Protection via the Coronary Sinus in Cardiac Surgery: Comparative Evaluation of Two Techniques....Pages 305-311
Myocardial Protection: Antegrade versus Retrograde Cardioplegia, a Clinical Trial on 145 Patients....Pages 312-315
Cardioplegia via the Coronary Sinus. Our Experience in 331 Cases....Pages 316-319
The Beck Era: A Springboard for Renewed Research of Coronary Venous Retroperfusion Aimed at Treatment of Myocardial Ischemia....Pages 320-327
Arterialization of the Left Anterior Descending Coronary Vein in Dogs: Successful Long-Term Flow Evaluation....Pages 328-335
Selective Arterialization of the Coronary Venous System Under Low Pressure....Pages 336-342
Fundamental Consideration of Synchronized Coronary Venous Retroperfusion: an Alternate Vascular Channel for Protection of Jeopardized Ischemic Myocardium....Pages 343-346
Synchronized Coronary Venous Retroperfusion: A Safe and Effective Treatment of Acute Myocardial Ischemia....Pages 347-353
Failure of Regional Coronary Vasodilator Drugs to Potentiate the Retroperfusion Beneficial Effect in Ischemic Myocardium in Dogs....Pages 354-359
Use of Microspheres Technique to Assess Regional Myocardial Blood Flow Distribution with Coronary Sinus Retroperfusion....Pages 360-366
New Catheter-Pump System for Diastolic Synchronized Coronary Sinus Retroperfusion (D.S.R.)....Pages 367-374
Effects of Synchronized Retroperfusion on Left Ventricular Function Measured by Two Dimensional Echocardiography....Pages 375-379
Synchronized Coronary Sinus Retroperfusion: The Effect on the Coronary Sinus....Pages 380-384
Coronary Venous Retroinfusion of Procainamide in the Management of Inducible Ventricular Tachyarrhythmias in Conscious Dogs, During Chronic Myocardial Infarction....Pages 385-391
Superiority of Hypothermic vs. Normothermic Synchronized Coronary Venous Retroperfusion for Protection of Acutely Ischemic Myocardium....Pages 392-402
Effects of Hypothermic Coronary Venous Retroperfusion on Myocardial Temperature Distribution and Left Ventricular Function....Pages 403-410
The Effects of Arterial Reperfusion, Synchronized Diastolic Coronary Venous Retroperfusion and Pressure Controlled Intermittent Coronary Sinus Occlusion on the Morphologic Evolution of Myocardial Infarction....Pages 411-417
Coronary Sinus Assessment of Left Ventricular Pressure in Man....Pages 424-429
The Hemodynamic Consequences of Coronary Sinus Occlusion....Pages 430-436
Effects of PICSO on Hemodynamic Parameters....Pages 437-444
Pressure Controlled Intermittent Coronary Sinus Occlusion Effects the Myocardium at Risk and Reduces Infarct Size....Pages 445-453
Intermittent Obstruction of the Coronary Sinus Following Coronary Ligation in Dogs Reduces Ischemic Necrosis and Increases Myocardial Perfusion....Pages 454-464
Intermittent Coronary Sinus Occlusion: Effects on Regional Function of the Normal and Ischemic Myocardium....Pages 465-472
Effects of Pressure Controlled Intermittent Coronary Sinus Occlusion (PICSO) on Metabolism and Regional Function in the Normally Perfused and in the Underperfused Canine Myocardium....Pages 473-482
The Effect of Pressure Controlled Intermittent Coronary Sinus Occlusion During Ischemia....Pages 483-489
Effects of Pressure Controlled Intermittent Coronary Sinus Occlusion (PICSO) During Acute Coronary Occlusion: Effects on Regional Left Ventricular Function and Infarct Size....Pages 490-496
The Arteriovenous Density Gradient as an Index for Myocardial Function....Pages 497-507
Effects of PICSO on Purine Nucleotides in Ischemic Canine and Reperfused Human Hearts....Pages 508-515
Effects of Pressure Controlled Intermittent Coronary Sinus Occlusion on Regional Myocardial Blood Flow and Tissue Electrolytes....Pages 516-522
Changes in Coronary Artery Flow as Reaction to Coronary Sinus Occlusion....Pages 523-528
Optimization of Pressure Controlled Intermittent Coronary Sinus Occlusion Intervals by Density Measurement....Pages 529-536
Enhancement of Washout Induced by Pressure Controlled Intermittent Coronary Sinus Occlusion (PICSO) in the Canine and Human Heart....Pages 537-548
Summarizing Statement of the Panel of Working Groups....Pages 549-550
Closing Remarks....Pages 551-552
Back Matter....Pages 553-556

2013-07-23