This volume features a comprehensive set of protocols featuring a range of both old and new technologies that can be used to analyze drugs of abuse, including prescription drugs, new psychoactive substances and psychoactive plants. Chapters guide readers through the application of color tests, light microscopy-based particle imaging, GC-MS, Raman spectroscopy, capillary electrophoresis, ultra-high performance LC-tandem MS, DART-MS, MALDI-mass spectrometry imaging, LC-MS/MS and HPLC-ESI-MS/MS to the analysis of abused drugs in wastewater, hair, urine and plant-derived materials, among other matrices. Written in the highly successful __Methods in Molecular Biology__ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, __Analysis of Drugs of Abuse__ aims to ensure successful results in the further study of this vital field.

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Humana Press : Springer

Methods in molecular biology (Clifton, N.J.), v. 1810, New York, N.Y, 2018

Methods in Molecular Biology 1810, 1st ed., 2018

United States, United States of America

1st ed. 2018, 2018

Jul 05, 2018

sm70700375

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Source title: Analysis of Drugs of Abuse (Methods in Molecular Biology)

Front Matter ....Pages i-xii
Color Tests for the Preliminary Identification of New Psychoactive Substances (Kaitlyn Toole, Morgan Philp, Nadine Krayem, Shanlin Fu, Ronald Shimmon, Sonia Taflaga)....Pages 1-11
Illicit and Counterfeit Drug Analysis by Morphologically Directed Raman Spectroscopy (Andrew C. Koutrakos, Pauline E. Leary, Brooke W. Kammrath)....Pages 13-27
Analysis of Drugs of Abuse by Gas Chromatography–Mass Spectrometry (GC-MS) (Thomas A. Brettell, Benny J. Lum)....Pages 29-42
Toward Confirmatory On-Site Real-Time Detection of Emerging Drugs Using Portable Ultrafast Capillary Electrophoresis Mass Spectrometry (Mehdi Moini)....Pages 43-58
Use of DART-TOF-MS for Screening Drugs of Abuse (Robert R. Steiner)....Pages 59-68
Confirmation of Pharmaceutical Identifiers via DART-TOF-MS (Jacob Easter)....Pages 69-74
UPLC-Orbitrap® Screening for over 35 Drugs of Abuse and Metabolites in Biological Fluids in Under 10 min (Eshwar Jagerdeo, Jason E. Schaff)....Pages 75-87
Sensitivity Enhancement in Capillary Electrophoresis Using Magnetic Particles as Solid-Phase Extraction Sorbents for the Determination of Drugs of Abuse in Urine (Tatiana Baciu, Francesc Borrull, Carme Aguilar, Marta Calull)....Pages 89-96
High-Throughput Extraction and Detection of Drugs in Urine: Parallel Sampling with Solid-Phase Microextraction (SPME) Fibers Coupled with Direct Analysis in Real Time-Mass Spectrometry (DART-MS) Detection (Frederick Li, Brian Musselman)....Pages 97-106
Analysis of Drugs of Abuse in Hair Samples by Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry (UHPLC-MS/MS) (D. Di Corcia, A. Salomone, E. Gerace)....Pages 107-114
Comprehensive Drug Screening by Thermal Desorption and Pyrolysis Combined with Direct Analysis in Real Time-Mass Spectrometry (TDP/DART-MS) (Hiroko Abe, Chikako Takei, Motoshi Sakakura, Daisuke Yajima, Hirotato Iwase)....Pages 115-124
Detection of Diagnostic Plant-Derived Psychoactive Biomarkers in Fingerprints by MALDI-SpiralTOF-Mass Spectrometry Imaging (Cameron M. Longo, Rabi A. Musah)....Pages 125-132
Matrix-Assisted Laser Desorption Ionization Imaging Mass Spectrometry of Drug Distribution in Mouse Brain Tissue by High-Resolution Time-of-Flight Mass Spectrometry (Takaya Satoh, Ayumi Kubo, Hisanao Hazama)....Pages 133-139
Estimation of Community Usage of Drugs Utilizing Sewage Epidemiology (Bikram Subedi)....Pages 141-147
LC-MS-MS Method Development and Analysis of Stimulants, Opiates, Synthetic Opiates, PCP, and Benzodiazepines in Wastewater. Preponderance of these Drugs During Football Games (Waseem Gul, Shahbaz W. Gul, Brandon Stamper, Murrell Godfrey, Mahmoud A. ElSohly)....Pages 149-182
Analysis of Illicit Drugs in Wastewater Using High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (HPLC-ESI-MS/MS) (Katelyn S. Foppe, Bikram Subedi)....Pages 183-191
Analysis of Trace Drugs of Abuse by Direct Analysis in Real Time (DART) Mass Spectrometry (David D. Cunningham)....Pages 193-205
A Rapid, High-Throughput Validated Method for the Quantification of Atropine in Datura stramonium Seeds Using Direct Analysis in Real Time-High Resolution Mass Spectrometry (DART-HRMS) (Ashton D. Lesiak, Kristen L. Fowble, Rabi A. Musah)....Pages 207-215
Utilizing Direct Analysis in Real Time-High Resolution Mass Spectrometry-Derived Dark Matter Spectra to Classify and Identify Unknown Synthetic Cathinones (Kristen L. Fowble, Rabi A. Musah)....Pages 217-225
Back Matter ....Pages 227-231

Methods in Molecular Biology
Erscheinungsdatum: 05.07.2018

2018-08-15