Annotation Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death - from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead

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nexusstc/Proteases: Structure and Function/9b50bc66b99b26b1042da7526efae6bb.pdf

scihub/10.1007/978-3-7091-0885-7.pdf

zlib/Science (General)/Neil D. Rawlings (auth.), Klaudia Brix, Walter Stöcker (eds.)/Proteases: Structure and Function_2318593.pdf

Klaudia Brix, Walter Stöcker, editors

Brix, Klaudia; Stöcker, Walter

Springer Vienna : Imprint : Springer

Springer Verlag GmbH

Springer Nature, Vienna, 2013

Wien, New York, Austria, 2013

New York, Feb. 2014

Austria, Austria

Vienna, 2012

2013, 2014

sm22966493

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Includes bibliographical references and index.

Protease Families, Evolution and Mechanism of Action -- Neil D. Rawlings
Kinetics of the Interaction of Peptidases with Substrates and Modifiers -- Antonio Baici, Marko Novinec and Brigita Lenarčič
Compartmentalization of Proteolysis -- Klaudia Brix, Christopher J. Scott and Margarete M. S. Heck
Cathepsins: Getting in Shape for Lysosomal Proteolysis -- Ann H. Erickson, Ciro Isidoro, Lukas Mach and John S. Mort
Limited and Degradative Proteolysis in the Context of Posttranslational Regulatory Networks: Current Technical and Conceptional Advances -- Stefan Tholen, Maria Magdalena Koczorowska, Zon Weng Lai and Joern Dengjel...
Exploring Systemic Functions of Lysosomal Proteases: The Perspective of Genetically Modified Mouse Models -- Martina Gansz, Ursula Kern, Christoph Peters and Thomas Reinheckel
Astacins: Proteases in Development and Tissue Differentiation -- Walter Stöcker and F. Xavier Gomis-Rüth
Proteases in Death Pathways -- Andreas Flütsch and Markus G. Grütter
ADAM Proteases in Physiology and Pathophysiology: Cleave to Function in Health or to Cause Disease -- Joachim Grötzinger and Stefan Rose-John
Proteases in the Nervous System -- Holger Cynis, Stefan F. Lichtenthaler, Leona Wagner and Hans-Ulrich Demuth
Proteases in the Mammalian Digestive System -- S. Gaylen Bradley, Toni M. Antalis and Judith S. Bond
Calpains in Health and Disease -- John Anagli, Kevin K. W. Wang, Yasuko Ono and Hiroyuki Sorimachi
Metalloproteinases in Cartilage Matrix Breakdown: The Roles in Rheumatoid Arthritis and Osteoarthritis -- Hideaki Nagase and Gillian Murphy
MMP-Mediated Collagen Remodeling and Vessel Functions -- Agnès Noel and Nor Eddine Sounni
Proteases in Cancer: Significance for Invasion and Metastasis -- Bonnie F. Sloane, Karin List, Barbara Fingleton and Lynn Matrisian.

Front Matter....Pages i-xii
Protease Families, Evolution and Mechanism of Action....Pages 1-36
Kinetics of the Interaction of Peptidases with Substrates and Modifiers....Pages 37-84
Compartmentalization of Proteolysis....Pages 85-125
Cathepsins: Getting in Shape for Lysosomal Proteolysis....Pages 127-173
Limited and Degradative Proteolysis in the Context of Posttranslational Regulatory Networks: Current Technical and Conceptional Advances....Pages 175-216
Exploring Systemic Functions of Lysosomal Proteases: The Perspective of Genetically Modified Mouse Models....Pages 217-233
Astacins: Proteases in Development and Tissue Differentiation....Pages 235-263
Proteases in Death Pathways....Pages 265-302
ADAM Proteases in Physiology and Pathophysiology: Cleave to Function in Health or to Cause Disease....Pages 303-318
Proteases in the Nervous System....Pages 319-371
Proteases in the Mammalian Digestive System....Pages 373-393
Calpains in Health and Disease....Pages 395-431
Metalloproteinases in Cartilage Matrix Breakdown: The Roles in Rheumatoid Arthritis and Osteoarthritis....Pages 433-469
MMP-Mediated Collagen Remodeling and Vessel Functions....Pages 471-489
Proteases in Cancer: Significance for Invasion and Metastasis....Pages 491-550
Back Matter....Pages 551-564

2014-02-12