This volume is based on the Proceedings of the International Conference on "Microbial Infections: Role of Biological Response Modifiers" held in Tampa, FL, May 29-31, 1991. The major purpose of this conference was to bring together in one forum prominent investigators from around the world studying a variety of microbial pathogens, including bacteria, viruses, and fungi, and the effects of biological response modifiers (BRM) on the immune response to these microorganisms. BRM have been widely utilized in the area of antitumor resistance and include not only experimental tumor cell vaccines, but also biologically active substances such as cytokines, i. e. , interferons, tumor necrosis factor, and interleukins, as well as products from bacteria which influence host resistance mechanisms. It is the belief of the organizers of this Conference that it was very timely to discuss in detail BRMs as they impact on microbial infections per se. It is now widely accepted that immunocompromised individuals, including those exposed to immunosuppressive substances such as antimetabolites used for chemothera py of malignancies, or infectious agents, such as the human immunodeficiency virus and other viruses which depress the immune response and, in turn, affect a host so as to become highly susceptible to opportunistic microorganisms, benefit from BRM stimulation of their immune system. A wide variety of immunomodulators are now being studied in terms of treating infectious diseases, as well as malignancy and autoimmune diseases.
Erscheinungsdatum: 01.11.2012

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Springer London, Limited

Advances in Experimental Medicine and Biology Ser, v.319, New York, NY, 1992

Advances in experimental medicine and biology, 319, Boston, MA, 1992

United States, United States of America

Springer Nature, New York, NY, 2012

Nov 01, 2012

1992, 2012

lg985990

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Source title: Microbial Infections (Advances in Experimental Medicine and Biology)

Front Matter....Pages i-x
Immunomodulatory Drugs of Relevance to the Management of Microbial Infections....Pages 1-11
Recent Thoughts on the Immunotherapy of Infectious Diseases Including HIV Infection....Pages 13-22
Identification and Characterization of Mammalian Cell Membrane Receptors for LPS-Endotoxin....Pages 23-29
Bacterial Polysaccharides, Endotoxins, and Immunomodulation....Pages 31-38
Immunomodulation of C3H/HeJ Cells by Endotoxin Associated Protein and Lipopolysaccharide Endotoxin....Pages 39-48
Bacterial Protein-LPS Complexes and Immunomodulation....Pages 49-61
Suppression of Antibody Forming Cells by Lipid a Analogs....Pages 63-67
BRM Activities of Low-Toxic Bordetella Pertussis Lipopolysaccharides....Pages 69-76
Interleukin-2 and the Regulation of Activated Macrophage Cytotoxic Activities....Pages 77-88
Protective Effects of Cytokines in Murine Salmonell....Pages 89-95
Legionella Pneumophila Infection and Cytokine Production....Pages 97-104
Cytokine Activation of Killer Cells in Mycobacterial Immunity....Pages 105-112
T Cell-Monocyte Interactions Induced by Listeria Monocytogenes ....Pages 113-123
Antigen Specific Suppressor T Cells Respond to Cytokines Released by T Cells....Pages 125-135
“Inverse” Effects of Cortisone in Experimental Infection of Mice....Pages 137-143
Bacterial Cell Surface Biological Response Modifiers and their Synthetic Counterparts....Pages 145-164
Determination of the Antiinfectious Activity of RU 41740 (Biostim) as an Example of an Immunomodulator....Pages 165-174
MDP Derivatives and Resistance to Bacterial Infections in Mice....Pages 175-184
Therapeutic and Prophylactic Effects of Romurtide Against Experimental Animal Infections....Pages 185-191
Enhancement of Host Resistance to Opportunistic Infections by Ubenimex (Bestatin)....Pages 193-200
Potentiation of Host Resistance Against Microbial Infections by Lentinan and its Related Polysaccharides....Pages 201-215
Cytokines and Anti-Fungal Immunity....Pages 217-223
Cryptococcal Immunity and Immunostimulation....Pages 225-230
Immunomodulators and Fungal Infections: Use of Antifungal Drugs in Combination with G-CSF....Pages 231-241
Biologic Response Modifiers as Antivirals in Immunosuppressed Hosts....Pages 243-251
Stimulation of Host-Defense Mechanism with Synthetic Adjuvants and Recombinant Cytokines Against Viral Infection in Mice....Pages 253-263
ADF (Adult T Cell Leukemia-Derived Factor)/Human Thioredoxin and Viral Infection: Possible New Therapeutic Approach....Pages 265-274
Antiviral and Adjuvant Activity of Immunomodulator Adamantylamide Dipeptide....Pages 275-286
Immunomodulation by Medicinal Plants....Pages 287-297
Immunomodulating Effects of Polysaccharides from Medicinal Plants....Pages 299-308
Effects of Sho-Saiko-to on Cytokine Cascade and Arachidonic Acid Cascade....Pages 309-317
Effects of Medicinal Plants on Hemopoietic Cells....Pages 319-330
Multiple Immunological Functions of Extracts from the Cone of Japanese White Pine, Pinus Parviflora Sieb. et Zucc ....Pages 331-335
Biological Response Modifiers in Infectious Diseases: Prospectives for the Future....Pages 337-339
Back Matter....Pages 341-347

This volume is based on the Proceedings of the International Conference on "Microbial Infections: Role of Biological Response Modifiers" held in Tampa, FL, May 29-31, 1991. The major purpose of this conference was to bring together in one forum prominent investigators from around the world studying a variety of microbial pathogens, including bacteria, viruses, and fungi, and the effects of biological response modifiers (BRM) on the immune response to these microorganisms. BRM have been widely utilized in the area of antitumor resistance and include not only experimental tumor cell vaccines, but also biologically active substances such as cytokines, i. e., interferons, tumor necrosis factor, and interleukins, as well as products from bacteria which influence host resistance mechanisms. It is the belief of the organizers of this Conference that it was very timely to discuss in detail BRMs as they impact on microbial infections per se. It is now widely accepted that immunocompromised individuals, including those exposed to immunosuppressive substances such as antimetabolites used for chemotheraƯ py of malignancies, or infectious agents, such as the human immunodeficiency virus and other viruses which depress the immune response and, in turn, affect a host so as to become highly susceptible to opportunistic microorganisms, benefit from BRM stimulation of their immune system. A wide variety of immunomodulators are now being studied in terms of treating infectious diseases, as well as malignancy and autoimmune diseases

2013-08-01