The rapid advances made in the study of the synthesis, structure and function of biological macromole cules in the last fifteen years have enabled scientists concerned with antimicrobial agents to achieve a considerable measure of understanding of how these substances inhibit cell growth and division. The use of antimicrobial agents as highly specific inhibitors has in turn substantially assisted the investigation of complex biochemical processes. The literature in this field is so extensive, however, that we considered an attempt should be made to draw together in an introductory book the more significant studies of recent years. This book, which is in fact based on lecture courses given by us to undergraduates at Liverpool and Manchester Universities, is therefore intended as an introduction to the biochemistry of antimicrobial action for advanced students in many disciplines. We hope that it may also be useful to established scientists who are new to this area of research. The book is concerned with a discussion of medically important antimicrobial compounds and also a number of agents that, although having no medical uses, have proved invaluable as research tools in bio chemistry. Our aim has been to present the available information in a simple and readable way, empha sizing the established facts rather than more controversial material. Whenever possible, however, we have indicated the gaps in the present knowledge of the subject where further information is required.
Erscheinungsdatum: 29.03.2000

lgrsnf/D:\HDD4\!genesis\1\SPR_NEW_2014-01\bok%3A978-94-010-9127-5.pdf

nexusstc/Biochemistry and Molecular Biology of Antimicrobial Drug Action/5bd126785c3381b26f36f6edfdf79393.pdf

zlib/Science (General)/T. J. Franklin, G. A. Snow (auth.)/Biochemistry and Molecular Biology of Antimicrobial Drug Action_2318901.pdf

Trevor J Franklin

International Thomson Computer Press

Springer Science + Business Media BV

Kluwer Academic Publishers

Springer London, Limited

Cengage Learning EMEA

Thomson Learning

Springer Nature

United Kingdom and Ireland, United Kingdom

Springer Nature, Dordrecht, 2012

5th ed, 3300 AZ Dordrecht, 1998

Fifth edition, Dordrecht, 2000

Fifth edition, Dordrecht, 1998

1st ed. 1998, Dordrecht, 1998

Netherlands, Netherlands

1, 20121206

1998, 2000

lg1150213

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Front Matter....Pages i-x
The development of antimicrobial agents past, present and future....Pages 1-14
Vulnerable shields — the cell walls of bacteria and fungi....Pages 15-41
Antiseptics, antibiotics and the cell membrane....Pages 43-59
Inhibitors of nucleic acid synthesis....Pages 61-76
Inhibitors of protein biosynthesis....Pages 77-96
Antimicrobial drugs with other modes of action....Pages 97-106
Penetrating the defences: how antimicrobial drugs reach their targets....Pages 107-118
The genetic basis of resistance to antimicrobial drugs....Pages 119-131
Biochemical mechanisms of resistance to antimicrobial drugs....Pages 133-157
Back Matter....Pages 159-166

"This book primarily covers medically important antimicrobial agents, but also includes some compounds not in current medical use which have been invaluable as research tools in biochemistry. It will be of great use to medical and biological sciences students taking courses in pharmacology, molecular biology, microbiology, biochemistry and chemotherapeutics."--BOOK JACKET

2014-02-12