This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells. The text covers basic knowledge of stem cell biology, stem cell ethics, development of techniques for applying stem cell therapy, the technology of obtaining appropriate cells for transplantation as well as the role of stem cells in cancer and how therapy may be directed to cancer stem cells. This new volume is essential reading for all scientists currently in the field or allied research areas, and those for those graduate students who envision a career in stem cells.
Erscheinungsdatum: 16.08.2013

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Stewart Sell; Humana

PdfCompressor 3.1.34

Sell, Stewart

Humana Press ; Springer

Springer Science

Springer US

Second edition, Totowa, New Jersey], New York, 2013

United States, United States of America

2nd ed. 2013, July 2013

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Adobe Acrobat 8.0

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Front Matter....Pages i-xvi
Introduction to Stem Cells....Pages 1-27
Contemporary Ethical Issues in Stem Cell Research....Pages 29-37
Front Matter....Pages 39-39
Stem Cells from Early Mammalian Embryos....Pages 41-57
Quantitative Approaches to Model Pluripotency and Differentiation in Stem Cells....Pages 59-74
Growth Dynamics of Fetal Human Neural Stem Cells....Pages 75-89
Immunobiology of Embryonic and Induced Pluripotent Stem Cell Transplantation....Pages 91-104
Front Matter....Pages 105-105
Urodele Limb Regeneration: Mechanisms of Blastema Formation and Growth....Pages 107-117
Mechanism of miR-302-Mediated iPS Cell Generation....Pages 119-127
Bioreactor Expansion of Pluripotent Stem Cells....Pages 129-138
Generation of Hepatocyte-Like Cells from Human Pluripotent Stem Cells....Pages 139-147
Neural Differentiation from Pluripotent Stem Cells....Pages 149-160
Generation of Anterior Foregut Derivatives from Pluripotent Stem Cells....Pages 161-175
Commercial Opportunities for Induced Pluripotent Stem Cells....Pages 177-199
Front Matter....Pages 201-201
Spermatogonial Stem Cells in Adult Mice and Men....Pages 203-210
Characterization of the Hematopoietic Stem Cell Niche: Cellular and Molecular Analysis....Pages 211-221
Glandular Stem Cells (GSCs): Stem Cells in Glandular Organs....Pages 223-233
Human Mammary Epithelial Stem/Progenitor Cells....Pages 235-244
Mammary Epithelial Stem Cells....Pages 245-254
Gastric Stem Cell Biology: Proliferation Kinetics, Differentiation Hierarchies, and Role in Carcinogenesis....Pages 255-269
Progenitors of Islet Cells....Pages 271-281
Front Matter....Pages 201-201
Stem Cell Populations Giving Rise to Liver, Biliary Tree, and Pancreas....Pages 283-310
Liver Regeneration in Health and Disease....Pages 311-320
Human-Induced Pluripotent Stem Cells, Embryonic Stem Cells, and Their Cardiomyocyte Derivatives: An Overview....Pages 321-345
Potential of Glial Cells....Pages 347-361
Stem Cells and Aging....Pages 363-373
Front Matter....Pages 375-375
Translating Stem Cell Discoveries....Pages 377-389
Mesenchymal Stromal/Stem Cell Transplantation: From Tissue Regeneration to Immune Modulation....Pages 391-397
Stem Cells and Tissue Engineering in Burns and Wounds....Pages 399-409
Derivation of Retinal Pigmented Epithelial Cells for the Treatment of Ocular Disease....Pages 411-418
Stem Cells and Diabetes....Pages 419-426
Front Matter....Pages 427-427
Cancer Is a Problem of Developmental Biology: Maturation Arrest and the Hierarchical Model of the Origin of Cancer from Stem Cells....Pages 429-440
Targeting the Stem Cell Plasticity of Tumor Cells....Pages 441-448
Molecular Evolution of Leukemia Stem Cells....Pages 449-458
Rodent Models for Assessing the Role of Stem Cells in Liver Development, Regeneration, and Carcinogenesis....Pages 459-476
Breast Cancer Stem Cells: From Theory to Therapy....Pages 477-489
Nephroblastoma/Wilms Tumor: A Corrupted Cap Stem Cell Caricature....Pages 491-509
Back Matter....Pages 511-534

Stem Cells Handbook, second edition, emphasizes the advances in understanding and working with embryonic and fetal stem cells as well as induced pluripotent stem cells that show the most promise for clinical use. This new edition has been completely rewritten and updated to reflect the significant advances made in this field since publication of the first edition in 2004. The thirty-six chapters in this book - all written by recognized experts in Stem Cell research - reflect the tremendous progress in the understanding of stem cell biology and the appreciation of the potential for using stem cells for therapy of cancer, aging, injury and congenital diseases. Arguably the biggest advances have been made in obtaining different populations of stem cells, inducing mature cells to act like stem cells, and the ever-critical issue of how to get these stem cells to expand and differentiate into the tissue precursor cells that then can be used to replace lost of damaged tissues. No less exciting are the recent advances in understanding how stem cells function to maintain tissue integrity and how to use this knowledge to prevent developmental abnormalities. Other key topics discussed include: properties of tissue stem cells , transplantation of stem cells, the stem cell as a target for cancer treatment and prevention

2013-08-20