Michigan State Univ., East Lansing. Translates knowledge into reproducible methods than enable biomedical researchers to explore the role of angiotensin in health and disease. Covers genetic manipulation of targeted genes. Includes methods for functional studies of the renin-angiotensin system. DNLM: Renin - Angiotensin System-physiology

lgrsnf/DVD-022/Wang_D._(ed.)_Angiotensin_Protocols_(2000)(en)(530s).pdf

nexusstc/Angiotensin Protocols/44f8558220b958f923b186ea09d800d3.pdf

zlib/Medicine/Donna H. Wang/Angiotensin Protocols_466176.pdf

Sabine Ellsasser

Wang, Donna H.

Humana ; Springer [distributor

Softcover reprint of the original 1st ed. 2001, July 2013

Methods in molecular medicine, Totowa, N.J., London, 2011

[Place of publication not identified], Unknown, 2012

United States, United States of America

mexmat -- 22

lg29887

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A qualitative leap in the understanding of cardiovascular and n- ral regulation by the renin–angiotensin system, and of the role of this s- tem in tissue damage, has occurred as a result of the many recent advances in molecular genetic techniques. The cloning of the genes for the components of the renin–angiotensin system, the design of specific angiotensin receptor ligands, and the use of embryonic gene targeting te- niques for the creation of mutant strains have established that the renin– angiotensin system is important in blood pressure regulation, ion and fluid homeostasis, and tissue growth and remodeling Further investigation of the mechanisms by which this system p- ticipates in cardiovascular regulation may shed some light on the pat- genesis of several cardiovascular diseases, e. g. , hypertension, congestive heart failure, and chronic renal failure. Despite the promise of this system as a target for therapeutic interventions for these diseases, there are great challenges in the integration of the attempts to close the gap between the traditional literature of medicine and the explosion of information from the new technologies. This book’s title, Angiotensin Protocols, reflects the authors’ strong efforts to translate expert knowledge into easy-to-follow practice. The book opens with introductory chapters, and each specialty section provides detailed methods covering a wide variety of techniques, ranging from genetic manipulation of targeted genes to functional studies of the renin– angiotensin system.
Erscheinungsdatum: 12.12.2011

2009-07-20