Neovascularization isanormalphaseoftissue repair mechanlsm. In theeye, however, sproutingofnewvessels withinavasculartissuesandtheirgreatertendencytobleed havedetrimentaleffectsonvision. Diabeticretinopathy, corneal neovascularization, age-related macular degeneration, retinal veinocclusion, andretinopathy of prematurity are major causes of blindness. In all, uncontrolled proliferationofnewvesselsistheunderlying pathologicalcauseleadingtotheinexorablelossofvision. Development of lasertechnologiesandtheir wide use in ophthalmology have broughtsomehopeforthetreqtment of these diseases. However, itbecameevident that direct closureofthenewvesselsand/orablationoflargepartsof thetissuearenotidealsolutionstotheproblem. Recent advances in molecular biology and genetic engineering have fosteredbasic knowledge regarding the growth factors and intercellular messengers and their association with theproliferationofnew blood vessels. These latter findings sparked a renewed interest in Michaelson's "X-factor" ofocular neovascularization and opened avenues for possible innovative therapeutic approaches. Therefore, the suggestion to organize an international gathering of clinicians and scientists interested in problems of ocular circulation and neovascularization was received with great enthusiasm. Unanimously, it wasdecidedtodedicatethe symposium to Professor I.C. Michaelson, theinnovativescientist, the greatclinician, theindefatigableteacher, andaboveall, thewonderfulhumanbeing. The meeting was highlighted by the outstanding atmosphere of friendshipandscientif·ic exchanges. This book mirrors the information delivered and includes a selectionofpapersfromthescientificprogram. Theorganizationofthismeetingandthepublicationof thebookwouldnothavebeenpossiblewithouttheharmonious teameffortsmadebytheInternational, ScientificandLocal Committees. I am thankful tothe chairpersons of the varioussessionsfortheirtime, keeninterestandendeavor for the realizationofahighscientific level. I also deeplyacknowledgethehelpand & upportofArnallPatz, Bob Murphy, BertGlaser, RobertFrank, LarryHjelmeland, Gordon Klintworth, Neville Welsh, Charles Riva, Alec Garner, DesmondArcher, EphraimFriedman, MyronYanoff, MosheLahav, Willem Manschot, Hans-WaltherLarsenand Masanobu Uyama. The powerful stimulus of Hanan Zauberman, Steve Ryan, GabrielCoscas, GiselleSoubrane, MosheIvry, YuvalYassur and Sue and Peter Ballenwasmost instrumental in the realizationofthese"dreams". Asalways, Iwasfortunate tohavetheinvaluablecollaborationofmyloyalassistants: Evelyne Cohen, Genia Maftzir, Israel Barzel, Arieh Zelikovitch, andJudithBenEzra. Thesmoothrunningofthe meeting andtimelyeditingofthebookcouldnothave been possible without theincalculablehelp and indefatigable typing and councilofJudithFisher, whoseconded me in selectingthepapersandeditingthebook

lgrsnf/A:\Springer\bok%3A978-94-009-3337-8.pdf

nexusstc/Ocular Circulation and Neovascularization/39ba557f9b01bef13f2773ee83e51c83.pdf

zlib/Medicine/David BenEzra (auth.), David BenEzra M.D., Ph.D.,, Stephen J. Ryan M.D., Bert M. Glaser M.D., Robert P. Murphy M.D. (eds.)/Ocular Circulation and Neovascularization_2239253.pdf

David BenEzra; International Symposium on Ocular Circulation and Neovascularization

Springer Science + Business Media BV

Documenta ophthalmologica, 50, Dordrecht, 1987

Springer Nature, Dordrecht, 2012

Netherlands, Netherlands

1, 2011

lg1070287

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Front Matter....Pages I-XXV
Introduction of the First Michaelson Medal Recipient....Pages 1-2
The Isaac C. Michaelson Lecture....Pages 3-10
Retinal Fluorotachometry....Pages 11-22
Isovolemic Hemodilution in Ischemic and Non-Ischemic Retinal Vein Occlusion....Pages 23-29
O 2 Gradients in the Miniature Pig Retina in Normoxia and Hyperoxia....Pages 31-35
Ocular blood supply in internal carotid obstructions....Pages 37-42
Retinal Hemodynamics in Diabetes Mellitus....Pages 43-45
Retinal Artery Emboli Associated with Mitral Valve Prolapse....Pages 47-51
Development of Retinal Neovascularisation in Occlusive Retinal Vascular Disease in Adults....Pages 53-56
Laser Photocoagulation for Retinal Vein Obstruction....Pages 57-63
Prevention of Clot Formation in Cat Retinal Vein by Systemic and Subconjunctival Urokinase....Pages 65-75
The Formation and Maintenance of New Blood Vessels....Pages 77-83
Mechanism of Elevated Membrane Formation and Posterior Vitreous Detachment in Diabetes Mellitus....Pages 85-92
Early Photocoagulation of Focal Diabetic Macular Edema....Pages 93-98
Photocoagulation for Diabetic Macular EDEMA: Results of the Early Treatment Diabetic Retinopathy Study....Pages 99-109
Juxta-Foveal Grid Treatment with Green Monochromatic Argon and with Red Krypton Lasers for Diabetic Macular EDEMA....Pages 111-115
Acute Diabetic Retinopathies....Pages 117-122
Angiogenic Factors in Human Vitreous....Pages 123-129
The Role of Ischaemia in the Pathogenesis of Retinal Neovascularisation....Pages 131-134
Optimal Strategy for ROP Screening....Pages 135-139
Influence of Statistical Methodology and Composition of Patient Populations on the Correlation of Risk Factors with Retinopathy of Prematurity....Pages 141-146
Retinopathy of Prematurity: Age at Onset and the Initial Site of Retinal Involvement. A Preliminary Report....Pages 147-153
Retinopathy of Prematurity: Treatment Approaches....Pages 155-156
Vitamin E at Pharmacologic Serum Levels and Incidence, Progression and Cicatricial Residua of Retinopathy of Prematurity....Pages 157-162
Does Vitamin E Have a Protective Role in the Retina as an Anti-Oxidant and Free Radical Scavenger?....Pages 163-167
Retinopathy of Prematurity, Past and Recent Experience in Denmark....Pages 169-173
“Rush Type” Retinopathy of Prematurity (ROP) - a Report of Three Cases....Pages 175-177
A Controlled Study on the Use of Cryotherapy in Prevention of Retrolental Fibroplasia (Retinopathy of Prematurity)....Pages 179-182
The Effect of Cryotherapy on Oxygen-Induced Retinopathy in the Newborn Kitten....Pages 183-191
ROP in Soroka Medical Center Neonatal I.C.U....Pages 193-196
Scleral Rigidity, Venous Obstruction, and Age-Related Macular Degeneration: A Working Hypothesis....Pages 197-204
Subfoveal Choroidal Neovascular Membranes Secondary to Age-Related Macular Degeneration: A Review....Pages 205-213
Zinc and Copper Metabolism Study in Patients with High Myopia and Senile Macular Degeneration....Pages 215-218
Natural History of Occult Subretinal New-Vessels in Age-Related Macular Degeneration....Pages 219-222
Monochromatic Argon Green Laser in the Treatment of Juxtafoveal Subretinal Neovascularization (SRNV) in Age Related Macular Degeneration (ARMD)....Pages 223-226
Laser Treatment of Occult Subretinal New Vessels in Age-Related Macular Degeneration: Feasability study and comparison with natural history....Pages 227-230
Argon Laser Treatment: Short and Long Term Results of Randomized Clinical Trials....Pages 231-239
Perifoveolar Laser Treatment for Subretinal New Vessels in Age-Related Macular Degeneration....Pages 241-246
Krypton Red Laser and Argon Green Laser Photocoagulation in the Treatment of Sick RPE Due to Age-Related Macular Degeneration....Pages 247-253
Senile Serous Detachment of R.P.E.-Lasertreatment: Controversial Aspects....Pages 255-259
Recurrent Choroidal Neovascularization Following Successful Photocoagulation in Age-Related Macular Degeneration....Pages 261-267
Evaluation of Conventional Therapy Versus Cyclosporin a in Behcet’s Disease....Pages 269-275
The Effects of the Cyclosporines on Ocular Inflammatory Disease....Pages 277-282
Lymphocyte Activity and the Role of Humoral Factors in Patients with Chronic Ocular Inflammation....Pages 283-289
Antibodies to Oral Mucosa in Patients with Ocular Behcet’s Disease....Pages 291-298
Best’s Vitelliform Macular Dystrophy Subretinal Neovascularization....Pages 299-306
Pigment Epitheliopathies-Clinical and Haematological Changes....Pages 307-312
Sub-Retinal Neo-Vascularisations of Uncommon Origin....Pages 313-317
Vasculitis and Morphology of Microvilli of the Conjunctiva in Sjogren Syndrome....Pages 319-325
Corneal Neovascularization: An Overview....Pages 327-333
The Rabbit Cornea - a Model for the Study of Angiogenic Factors....Pages 335-340
Immunologically Mediated Corneal Neovascularization in Inbred Mice....Pages 341-348
Vasoformative Factors in the Corneal Epithelium....Pages 349-354
Macrophage-Induced Neovascularization in the Mouse Eye: Correlation with Other in vivo and in vitro Tests of Angiogenesis....Pages 355-359
Heterogeneity of Vascular Endothelial Cells: Its Possible Role in Selective Neovascularization in the Eye....Pages 361-365
Corneal Endothelialization in Experimental Anterior Synechias and Rubeosis Iridis....Pages 367-372
Neovascular Glaucoma: Etiologic Factors and Management Considerations....Pages 373-378
Neovascular Glaucoma after Extracapsular Cataract Extraction in Diabetic Patients with Diabetic Retinopathy....Pages 379-381
Cryotherapy for Iris Neovascularization and Neovascular Glaucoma....Pages 383-386
Molteno Implants in Neovascular Glaucoma....Pages 387-391
Basement Membranes and Retinal Neovascularization....Pages 393-400
Localization of Angiogenesis Markers to Inner and Outer Retina....Pages 401-407
Pathological Changes in Retinal Vasculature Associated with Hereditary Retinal Dystrophy in RCS-Rats....Pages 409-417
Retinal Pigment Epithelial Tears and Subretinal Neovascularization....Pages 419-427
Interactions between the Retinal Pigment Epithelium and the Choriocapillaris after Krypton Laser Photocoagulation....Pages 429-435
Mechanisms of Lumen Formation: Morphologic Observations on Experimental Subretinal Neovascularization....Pages 437-443
Animal Model of RPE-Choriocapillaris Interactions: Sodium Iodate Retinopathy in the Rabbit....Pages 445-449
Choroidal Neovascularization and the Retinal Pigment Epithelium....Pages 451-459
Experimental Evidence that Capillaries Influence RPE Polarity....Pages 461-465
Involution of Subretinal Neovascularization....Pages 467-474
Choroidal Vascular Repair after Krypton Laser Photocoagulation in the Rat....Pages 475-479
Growth Characteristics of Retinal Microvascular Cells in Culture....Pages 481-488
Storage of Heparin-Binding Endothelial Cell Growth Factors in the Cornea: a New Mechanism for Corneal Neovascularization....Pages 489-498
The Nontumor Perspective: Angiogenesis and Geometry in Growth Control....Pages 499-504
Angiogenesis and Interleukins....Pages 505-509
The Role of Lactic Acid in the Mechanism of Neovascularization....Pages 511-516
Kinetics of Activation of Procollagenase by a Low Molecular Weight Mass, Non Protein Angiogenic Factor....Pages 517-523
Retinal Pigment Epithelial Cells Inhibit Vascular Endothelial Cells Invasion....Pages 525-528
A Mitogenic Factor or Factors Produced by Cultured Human Retinal Pigment Epithelial Cells....Pages 529-534
Retinal Pigment Epithelial Cells Release Inhibitors of Neovascularization....Pages 535-543
Inhibition of Neovascular Stimuli....Pages 545-550
Alec Garner....Pages 551-552
Arnall Patz....Pages 553-554
G. Soubrane....Pages 555-555
Robert B. Nussenblatt....Pages 557-559
M. Yanoff....Pages 561-562
Stephen Ryan....Pages 563-564
Bert M. Glaser....Pages 565-567
David BenEzra....Pages 569-573
Erratum to: Macrophage-Induced Neovascularization in the Mouse Eye: Correlation with Other in vivo and in vitro Tests of Angiogenesis....Pages 574-574

2013-12-12