This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease.
The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.

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scihub/10.1007/978-981-13-8946-7.pdf

zlib/Medicine/Sajal Chakraborti, Naranjan S. Dhalla, Madhu Dikshit, Nirmal K. Ganguly/Modulation of Oxidative Stress in Heart Disease_5402734.pdf

Chakraborti, Sajal; Dhalla, Naranjan S.; Dikshit, Madhu; Ganguly, Nirmal K.

Author

Springer Science + Business Media Singapore Pte Ltd

SPRINGER Verlag, SINGAPOR

Place of publication not identified, 2019

Springer Nature, Singapore, 2019

1st ed. 2019, Singapore, 2020

1st ed, Singapore, 2019

Singapore, Singapore

Nov 11, 2019

sm78321752

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Front Matter ....Pages i-xiii
Front Matter ....Pages 1-1
Modulation of Oxidative Stress in Heart Disease by Uncoupling Proteins (Zakaria A. Almsherqi, Bernita Yeo Hui Li, Yuling Zhou, Craig S. McLachlan)....Pages 3-21
Oxidant-Dependent and Oxidant-Independent Proangiogenic and Vasomotor Signaling in Coronary Vascular Endothelium (Sarah Aldosari, Maan Awad, May Z. Gao, Isabella G. McCormack, Frank W. Sellke, Md. Ruhul Abid)....Pages 23-61
Modulation of miRNA in Oxidative Stress-Induced Cardiac Remodeling (Sudhiranjan Gupta)....Pages 63-80
Myocardial Oxidative Stress and Metabolic Diseases (Hassan I. H. El-Sayyad)....Pages 81-105
Impact of Genetic and Epigenetic Factors on the Oxidative Stress in Cardiovascular Disease (Shiva Krishna Katkam, Bobbala Indumathi, Shaik Mohammad Naushad, Vijay Kumar Kutala)....Pages 107-128
Role of Monoamine Oxidases in Heart Diseases (Vinayak Gupta, Vikas Arige, Nitish R. Mahapatra)....Pages 129-150
Key Cellular Effectors in ROS-Mediated Cardiac Diseases (Ratul Datta Chaudhuri, Santanu Rana, Kaberi Datta, Sagartirtha Sarkar)....Pages 151-195
Reactive Oxygen Species Generation in Neutrophils: Modulation by Nitric Oxide (Sachin Kumar, Madhu Dikshit)....Pages 197-214
Heat Shock Proteins and Their Associated Oxidative Stress-Induced Heart Disease (Sangeeta Mitra, Rakhi Dasgupta, Angshuman Bagchi)....Pages 215-235
Modulation of Oxidative Stress in Cardiovascular Diseases (Jay C. Jha, Madhura Bose, Karin Jandeleit-Dahm)....Pages 237-253
Front Matter ....Pages 255-255
Oxidative Stress and Heart Failure (Bodh I. Jugdutt, Bernadine A. Jugdutt)....Pages 257-311
Oxidative Stress in Metabolic Syndrome: Experimental Model of Biomarkers (María del Carmen Baez, Mariana Tarán, Mónica Moya, María de la Paz Scribano Parada)....Pages 313-338
Oxidative Stress as a Critical Determinant of Adult Cardiac Progenitor Cell-Fate Decisions (Diego Herrero, Susana Cañón, Guillermo Albericio, Susana Aguilar, Rosa María Carmona, Adrián Holguín et al.)....Pages 339-363
Role of Oxidative Stress in Hyperhomocysteinemia-Induced Heart Diseases (Nevena Jeremic, Jovana Bradic, Anica Petkovic, Gregory Weber)....Pages 365-375
Nitrosative Stress and Cardiogenesis: Cardiac Remodelling Perturbs Embryonic Metabolome (Pavitra Kumar, Lakshmikirupa Sundaresan, Suvro Chatterjee)....Pages 377-391
Oxidative Stress in Pulmonary Artery Hypertension (Vinu Wilson, Subir Kumar Maulik)....Pages 393-402
Free Radicals and Reactive Oxygen Species in Cardiovascular Pathophysiology: An Overview (Shyamal K. Goswami)....Pages 403-418
Epigenetic Basis of Oxidative Stress in Diabetic Coronary Atherosclerosis: A Shift in Focus from Genetic Prerogative (Parimala Narne)....Pages 419-455
Role of Oxidative Stress, Mitochondrial Dysfunction, and Autophagy in Cardiovascular Disease: Its Pathogenesis and Amelioration by Different Small Natural Molecules (Sharmistha Chatterjee, Uday Hossain, Parames C. Sil)....Pages 457-487
Parkin Protein: The Missing Link Between Cardiovascular and Parkinson’s Disease (Angshuman Bagchi)....Pages 489-501
Front Matter ....Pages 503-503
New Technologies in Drug Development Provide New Hope in Targeting of Dysregulated Redox Signalling in Cardiovascular Disease (Soloman Saleh, Kristen Bubb, Gemma A. Figtree)....Pages 505-532
An Exercise Mimetic That Targets Nitroso-Redox Balance as a Therapeutic for Heart Disease (Vikram Shettigar, Mark T. Ziolo)....Pages 533-553
Myocardial Injury Secondary to Intestinal Ischemia/Reperfusion or Microbiota Disturbance: Preventive and Therapeutic Concerns (Emmanuel E. Douzinas, Aikaterini Apeiranthitis)....Pages 555-564
Multi-target Approach for Oxidative Stress Modulation by Aspirin, Salicylates and Other NSAIDs: Clinical Implications in Atherosclerosis (Eugenia Yiannakopoulou)....Pages 565-578
The Evolving Concept of Mitochondrial Dynamics in Heart: Interventional Opportunities (Ashok Sivasailam, Mahalaxmi Ganjoo, Varghese T. Panicker, Vivek V. Pillai, Srinivas Gopala)....Pages 579-627
Pharmacogenetic Implications of Statin Therapy on Oxidative Stress in Coronary Artery Disease (Nivas Shyamala, Surekha Rani Hanumanth)....Pages 629-644
Basic Mechanisms of Ischemia/Reperfusion Injury Leading to Cellular and Tissue Damage: Therapeutic Implications (Emmanuel E. Douzinas, Aikaterini Apeiranthitis)....Pages 645-670
Targeting Mitochondria for Therapy of Cardiovascular Disease (Biaus Samanta, Satabdi Banerjee, Suman K. Nandy, Sajal Chakraborti)....Pages 671-686

2019-11-13