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Adrenal Toxicology (Target Organ Toxicology Series Book 26) 🔍
W. Harvey Philip, David J. Everett, Christopher J. Springall Informa Healthcare USA, Target organ toxicology series 26, 1, 2009
英语 [en] · PDF · 10.6MB · 2009 · 📘 非小说类图书 · 🚀/lgli/lgrs/nexusstc/scihub/upload/zlib · Save
描述
Despite being regarded as the most common toxicological target in the endocrine system, the adrenal gland has often been neglected in regulatory testing. **__Adrenal Toxicology__ addresses the increased interest in adrenocortical toxicology and the need for a resource that makes techniques available to examine adrenal endocrine disruption.**
Examining current techniques and the latest advancements, **__Adrenal Toxicology__ reviews the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. This text provides information on the range of drugs and chemicals that affect adrenocortical function and suggests standardized approaches for in vivo and in vitro assessment. This volume also presents recent developments in the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.**
**__Adrenal Toxicology__ :**
* reflects the major developments made over the past decade
* focuses on the latest research techniques, including their uses and limitations
* provides an integrated strategy for adrenal toxicology evaluation
* identifies knowledge and data gaps, providing impetus for regulatory consideration
备用文件名
nexusstc/Adrenal Toxicology/2c902f658ae82b29e5d60f384b0f25d8.pdf
备用文件名
lgli/Adrenal Toxicology.pdf
备用文件名
lgrsnf/Adrenal Toxicology.pdf
备用文件名
scihub/10.3109/9781420061307.pdf
备用文件名
zlib/Medicine/W. Harvey Philip, David J. Everett, Christopher J. Springall/Adrenal Toxicology_599908.pdf
备选作者
Editor-philip W. Harvey; Editor-david Everett; Editor-christopher Springall
备选作者
Philip W. Harvey, David J. Everett, Christopher J. Springall, David Everett
备选作者
Adobe Acrobat 8.1 Combine Files
备用出版商
CRC : Taylor & Francis [distributor
备用出版商
Technomic Publishing Co., Inc.
备用出版商
Taylor & Francis Group
备用出版商
Taylor & Francis Ltd
备用出版商
CRC Press LLC
备用版本
Target organ toxicology series, New York, 2009 [i.e. 2008
备用版本
Target organ toxicology series, v. 26, New York, ©2009
备用版本
Target Organ Toxicology, 26, New York, 2008
备用版本
Target organ toxicology series 26, 1, 2008
备用版本
United Kingdom and Ireland, United Kingdom
备用版本
United States, United States of America
备用版本
CRC Press (Unlimited), New York, 2009
备用版本
Boca Raton, Fla., London, c2009
备用版本
1 edition, October 15, 2008
备用版本
1, PS, 2008
元数据中的注释
Kingdwarf -- to 2009-09
元数据中的注释
lg172523
元数据中的注释
producers:
Creo Normalizer JTP
元数据中的注释
{"edition":"1","isbns":["042914878X","1420061291","1420061305","9780429148781","9781420061291","9781420061307"],"last_page":338,"publisher":"CRC Press","series":"Target organ toxicology series 26"}
备用描述
<p><p>despite Being Regarded As The Most Common Toxicological Target In The Endocrine System, The Adrenal Gland Has Often Been Neglected In Regulatory Testing. Adrenal Toxicology Addresses The Increased Interest In Adrenocortical Toxicology And The Need For A Resource That Makes Techniques Available To Examine Adrenal Endocrine Disruption. </p><br><p></p><br><p>examining Current Techniques And The Latest Advancements, Adrenal Toxicology Reviews The Endocrinology, Pharmacology, Pathology And Toxicology Of The Adrenal Gland. This Text Provides Information On The Range Of Drugs And Chemicals That Affect Adrenocortical Function And Suggests Standardized Approaches For In Vivo And In Vitro Assessment. This Volume Also Presents Recent Developments In The Molecular Mechanisms Of Toxicity To The Adrenal Cortex And Medulla, And Considers Environmental Adrenal Endocrine Disruption In Sentinel Species.</p><br><p></p><br><p>adrenal Toxicology&#58;</p><br><p></p><br><br><br><br><br><p></p><br><br>reflects The Major Developments Made Over The Past Decade<br><br>focuses On The Latest Research Techniques, Including Their Uses And Limitations<br><br>provides An Integrated Strategy For Adrenal Toxicology Evaluation<br><br>identifies Knowledge And Data Gaps, Providing Impetus For Regulatory Consideration</p>
备用描述
Front Cover 1
Title Page 4
Preface 8
Contents 16
Chapter 1- Adrenal Toxicology: Molecular Targets, Endocrine Mechanisms, Hormonal Interactions, Assessment Models, and Species Differences in Toxicity 22
Chapter 2- An Overview of Human Adrenal Dysfunction 58
Chapter 3- The Hypothalamo-Pituitary-Adrenocortical Axis: Endocrinology, Pharmacology, Pathophysiology, and Developmental Effects 96
Chapter 4- The Adrenal Medulla as a Target Organ in Toxicologic Studies of Rats and Mice 130
Color Inserts 158
Chapter 5- Adrenal Gland Background Pathology of Primates in Toxicological Studies 166
Chapter 6- Hypothalamic-Pituitary-Adrenal Toxicity in Dogs 188
Chapter 7- Adrenocortical ToxicologyIn Vitro: Assessment of Steroidogenic Enzyme Expression and Steroid Production in H295R Cells 202
Chapter 8- Comparisons of Adrenocortical Cell Lines as In Vitro Test Systems 210
Chapter 9- Glucocorticoid PharmacotoxicologicalInteractions and Modulation of Toxicity 232
Chapter 10- Adrenocortical Toxicology in Fishes 260
Chapter 11- Adrenal Toxicology in Birds: Environmental Contaminants and the Avian Response to Stress 284
Index 322
Back Cover 338
备用描述
"Adrenal Toxicology addresses the increased interest in adrenocortical toxicology and the need for a resource that makes techniques available to examine adrenal endocrine disruption. Examining current techniques and the latest advancements the book reviews the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. It provides information on the range of drugs and chemicals that affect adrenocortical function and suggests standardized approaches for in vivo and in vitro assessment."--BOOK JACKET
开源日期
2010-01-07
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