In the last decade, research on platelet-activating factor (PAF) has expanded exponentially. Previous conferences on PAF in Paris, 1983, and the subsequent conferences in Gatlinburg, Ten­ nessee, Tokyo, Snowbird, Utah, and Berlin, at three-yearly intervals, have chronicled the devel­ opments in the field ofPAF. This volume records the proceedings of the Fifth International Con­ gress on PAF and Related Lipid Mediators, held at the Free University Medical Hospital Ben­ jamin Franklin in Berlin, from September 12-16, 1995. We are very much indebted to Free Uni­ versity Berlin for providing tremendous facilities and financial support. It was a great pleasure to have positive and generous input from the German Science Council (DFG), Bonn, Germany, and British·Biotech, Oxford, United Kingdom. Their support was crucial in making the congress a scientific success. Twenty other organizations provided additional financial support, for which we extend our deepest appreciation. The editors would like to thank all of those who participated in this congress and the authors for their contributions. The organization and planning of the Berlin Congress were carried out by an organizing committee. We gratefully acknowledge the support and assistance of the organizing commit­ tee members, especially Renate Nigam and Renate Roux for their untiring efforts to make the congress successful. Many colleagues also supported the congress with dedication, hard work, and expert input. We are grateful to them. We also wish to acknowledge the support of G. Sravan Kumar and Louis Kock for their efforts in producing this volume.

lgrsnf/A:\compressed\10.1007%2F978-1-4899-0179-8.pdf

nexusstc/Platelet-Activating Factor and Related Lipid Mediators 2: Roles in Health and Disease/2705f38bf7b6c4f3b35cc082272bb50a.pdf

zlib/Medicine/Donald J. Hanahan (auth.), Santosh Nigam, Gert Kunkel, Stephen M. Prescott (eds.)/Platelet-Activating Factor and Related Lipid Mediators 2: Roles in Health and Disease_2140941.pdf

S. K Nigam

Springer

Springer London, Limited

Advances in Experimental Medicine and Biology Ser, v.416, New York, NY, 1997

Advances in experimental medicine and biology, 416, Boston, MA, 1996

United States, United States of America

Springer Nature, New York, NY, 2013

1996, 2013

lg987014

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Front Matter....Pages i-xiv
The Continuing Biochemical Challenge of PAF and Closely Related Lipid Mediators....Pages 1-3
Biosynthesis of Platelet-Activating Factor and Enzyme Inhibitors....Pages 5-10
Inhibitors of Arachidonate Metabolism and Effects on PAF Production....Pages 11-15
Production of Platelet-Activating Factor by Brain Microvascular Endothelial Cells....Pages 17-20
PAF-Synthesizing Enzymes in Neural Cells during Differentiation and in Gerbil Brain during Ischemia....Pages 21-27
Platelet-Activating Factor Production in the Stimulated Macrophages is Enhanced by the Cyclooxygenase Inhibitors....Pages 29-32
The Role of Peroxisomes in Ether Lipid Synthesis....Pages 33-40
Platelet-Activating Factor Synthesis and Its Role in Salivary Glands....Pages 41-44
Physiological Action of PAF in Yeast Saccharomyces Cerevisiae ....Pages 45-50
Free Radical-Induced Oxidation of Glycerophosphocholine Lipids and Formation of Biologically Active Products....Pages 51-58
A Discovery Trip to Compounds with PAF-Like Activity....Pages 59-63
Biologically Active Lipids from S. Scombrus ....Pages 65-72
Purification and Partial Characterization of the PAF Antagonist from the Saliva of the Leech Hirudo Medicinalis ....Pages 73-77
Platelet-Activating Factor Receptor....Pages 79-84
Transcriptional Regulation of Platelet-Activating Factor Receptor Gene Expression in Leukocytes....Pages 85-87
PAF Receptor Anchors Streptococcus Pneumoniae to Activated Human Endothelial Cells....Pages 89-94
Up-Regulation of the Intracellular Ca 2+ Signaling and mRNA Expression of Platelet-Activating Factor Receptor by Estradiol in Human Uterine Endometrial Cells....Pages 95-100
Functional Role of Platelet-Activating Factor Receptor in Secretory Response in Adrenal Chromaffin Cells....Pages 101-105
Functional and Structural Features of Plasma Platelet-Activating Factor Acetylhydrolase....Pages 107-111
Acetylation of Sphingosine by PAF-Dependent Transacetylase....Pages 113-119
Platelet-Activating Factor Acetylhydrolase Activity in Human Follicular Fluid....Pages 121-127
The Prevention of Necrotizing Enterocolitis....Pages 129-133
Implication of PAF and Acetylhydrolase (PAF-AH) Activity in Periodontal Disease....Pages 135-141
Stimulation of NF-κB Activation and Gene Expression by Platelet-Activating Factor....Pages 143-151
Tyrosine Kinase Activation by PAF Leads to Downstream Gene Expression....Pages 153-155
Heterocyclic Alkylphospholipids with an Improved Therapeutic Range....Pages 157-164
Systemic Administration of Alkylphosphocholines....Pages 165-168
Arachidonate—Phospholipid Remodeling and Cell Proliferation....Pages 169-172
Protein Kinase C Inhibition by ET-18-OCH 3 and Related Analogs....Pages 173-180
Influence of Hexadecylphosphocholine (Miltefosine) on Cytokine Synthesis and Biological Responses....Pages 181-187
Effect of SM-12502 on Disseminated Intravascular Coagulation (DIC) in Tumor-Bearing Rats....Pages 189-193
Platelet-Activating Factor is an Effector of Rapid Reactions and an Inductor of Late Responses in Immune-Mediated Injury....Pages 195-199
Ether Lipid Metabolism, GPI Anchor Biosynthesis, and Signal Transduction are Putative Targets for Anti-Leishmanial Alkyl Phospholipid Analogues....Pages 201-211
PAF Response to Inflammatory and Non-Inflammatory Stimuli....Pages 213-216
Role of Platelet-Activating Factor in Skeletal Muscle Ischemia-Reperfusion Injury....Pages 217-221
Platelet-Activating Factor....Pages 223-230
Platelet-Activating Factor and Angiogenesis....Pages 231-234
Role of Synergistic Action of PAF and Kinin in Bacterial Endotoxin-Induced Hypotension in Rats....Pages 235-238
Epimer-Specific Actions of Hepoxilins A 3 and B 3 on PAF- and Bradykinin-Evoked Vascular Permeability in the Rat Skin in Vivo ....Pages 239-241
The Role of Platelet-Activating Factor in the Biocompatibility of Hemodialysis Membranes....Pages 243-248
Drug-Induced Alteration of Endothelial Permeability in the Rat Aorta....Pages 249-253
PAF Promotes the Development of the Preimplantation Embryo....Pages 255-261
PAF Released by Preimplantation Embryos Binds to Albumin....Pages 263-267
Role of Platelet-Activating Factor in Parturition....Pages 269-275
The Role of Platelet-Activating Factor and Its Receptor in Endometrial Receptivity....Pages 277-290
Non-Specific PAF Binding to Embryonal F9 Cells and Prostacyclin Synthesis in Human Umbilical Vein Endothelial Cells....Pages 291-295
Platelet-Activating Factor (PAF): Signalling and Adhesion in Cell-Cell Interactions....Pages 297-304
Identification and Molecular Characterization of the CalB Domain of the Cytosolic Phospholipase A 2 (cPLA 2 ) in Human Neutrophils....Pages 305-308
Characterization of Plasmalogen-Selective Phospholipase A 2 from Bovine Brain....Pages 309-313
Structure and Function of Phospholipase A 2 Receptor....Pages 315-319
PAF-Induced MAPK Activation is Inhibited by Wortmannin in Neutrophils and Macrophages....Pages 321-326
Activation of 85 kDa PLA 2 by Eicosanoids in Human Neutrophils and Eosinophils....Pages 327-331
Phosphatidylcholine Biosynthesis as a Target for Phospholipid Analogues....Pages 333-336
Endothelin-1 as One of the Mediators of the Interaction between Endothelium and Platelets in Humans....Pages 337-342
Evidence for Activation of Cyclooxygenase-1/-2 by Endogenous Nitric Oxide in Adjuvant Arthritic Lewis Rats....Pages 343-348
Phosphatidylinositol-3-Kinase Pathway is Stimulated by Fungal Lipid Containing Cocoa Butter Equivalents (CBE) in FMet-Leu-Phe (FMLP)- and Phorbolester (PMA)-Challenged Human Neutrophils....Pages 349-353
Platelet-Type Arachidonate 12-Lipoxygenase....Pages 355-359
Lexipafant(BB-882), A Potent PAF Antagonist in Acute Pancreatitis....Pages 361-363
The Use of Lexipafant in the Treatment of Acute Pancreatitis....Pages 365-370
Effect of a Potent Platelet-Activating Factor Antagonist, WEB-2086, on Asthma....Pages 371-380
Ex Vivo Inhibition of PAF-Induced β-Thromboglobulin Release in Man by ABT-299, a Potent PAF Antagonist....Pages 381-387
A Phase II Trial of Autologous Bone Marrow Transplantation (ABMT) in Acute Leukemia with Edelfosine Purged Bone Marrow....Pages 389-396
Back Matter....Pages 397-401

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