A wealth of information has been accumulated about the function of ion channels of excitable cells since the extensive and pioneering voltage clamp studies by Hodgkin, Huxley, and Katz 36 years ago. The study of ion chan nels has now reached a stage at which a quantum jump in progress is antici pated. There are many good reasons for this. Patch clamp techniques origi nally developed by Neher and Sakmann 12 years ago have made it possible to study the function of ion channels in a variety of cells. Membrane ionic currents can now be recorded practically from many types of cells using the whole-cell patch clamp technique. The opening and closing of individual ion channels can be analyzed using the single-channel patch clamp method. Techniques have also been developed to incorporate purified ion channels into lipid bilayers to reconstitute an "excitable membrane. " Advanced tech niques developed in molecular biology, genetics, and immunology, such as gene cloning and the use of monoclonal antibodies, are now being applied to the study of ion channels. A variety of drugs have now been found or are suspected to interact with ion channels to exert therapeutic effects. In addition to the classical exam ples, as represented by local anesthetics, many other drugs, including cal cium antagonists, psychoactive drugs, cardiac drugs, and anticonvulsants, shown to alter ion channel function. For certain pesticides such as have been pyrethroids and DDT, sodium channels are clearly the major target site.
Erscheinungsdatum: 12.12.2012

lgrsnf/A:\compressed\10.1007%2F978-1-4615-7302-9.pdf

nexusstc/Ion Channels: Volume 1/184418aa5eeb14bfcd8f5669fda595f4.pdf

zlib/Medicine/Kimon J. Angelides (auth.), Toshio Narahashi (eds.)/Ion Channels: Volume 1_2124795.pdf

edited by Toshio Narahashi

United States, United States of America

Springer Nature, New York, NY, 2012

Boston, MA, Massachusetts, 1988

Ion Channels, Boston, MA, 1988

Dec 12, 2012

lg970883

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Source title: Ion Channels: Volume 1 (Ion Channels (1))

A wealth of information has been accumulated about the function of ion channels of excitable cells since the extensive and pioneering voltage clamp studies by Hodgkin, Huxley, and Katz 36 years ago. The study of ion chanƯ nels has now reached a stage at which a quantum jump in progress is anticiƯ pated. There are many good reasons for this. Patch clamp techniques origiƯ nally developed by Neher and Sakmann 12 years ago have made it possible to study the function of ion channels in a variety of cells. Membrane ionic currents can now be recorded practically from many types of cells using the whole-cell patch clamp technique. The opening and closing of individual ion channels can be analyzed using the single-channel patch clamp method. Techniques have also been developed to incorporate purified ion channels into lipid bilayers to reconstitute an "excitable membrane." Advanced techƯ niques developed in molecular biology, genetics, and immunology, such as gene cloning and the use of monoclonal antibodies, are now being applied to the study of ion channels. A variety of drugs have now been found or are suspected to interact with ion channels to exert therapeutic effects. In addition to the classical examƯ ples, as represented by local anesthetics, many other drugs, including calƯ cium antagonists, psychoactive drugs, cardiac drugs, and anticonvulsants, shown to alter ion channel function. For certain pesticides such as have been pyrethroids and DDT, sodium channels are clearly the major target site

Front Matter....Pages i-xiii
Fluorescence Spectroscopy to Probe the Structure and Cellular Dynamics of Ion Channels....Pages 1-54
M Currents....Pages 55-94
Macromolecular Sites for Specific Neurotoxins and Drugs on Chemosensitive Synapses and Electrical Excitation in Biological Membranes....Pages 95-162
Developmental Changes in Acetylcholine Receptor Channel Properties of Vertebrate Skeletal Muscle....Pages 163-182
Intracellular ATP and Cardiac Membrane Currents....Pages 183-212
Calcium Antagonist Receptors....Pages 213-249
The Amiloride-Blockable Sodium Channel of Epithelial Tissue....Pages 251-282
Ionic Channels in Ocular Epithelia....Pages 283-327
Back Matter....Pages 329-334

2013-08-01