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The Chemistry of β-Lactams 🔍
J. E. Baldwin, C. Schofield (auth.), Michael I. Page (eds.) Springer Netherlands : Imprint : Springer, Softcover reprint of the original 1st ed. 1992, 2012
英语 [en] · PDF · 7.5MB · 1992 · 📘 非小说类图书 · 🚀/lgli/lgrs/nexusstc/scihub/zlib · Save
描述
It is over sixty years since Alexander Fleming observed antibiosis between a Penicillium mould and bacterial cultures and gave the name penicillin to the active principle. Although it was proposed in 1943 that penicillin (1) contained a tJ-Iactam ring, this was not generally accepted until an X-ray crystallographic determination of the structure had been completed. RCONH )=r)< o '" (I) 'C0 H 2 Penicillin was the first naturally occurring antibiotic to be characterised and used in clinical medicine. It is now seen as the progenitor of the tJ-Iactam family of antibiotics, which are characterised by the possession of the four membered tJ-Iactam ring. Chapters in this book will describe how current research has demonstrated that other lactam structures may also show antibacterial activity. Penicillins and cephalosporins (2), the second member of the tJ-Iactam antibiotic family, were both originally discovered in fungi but later detected in streptomycetes. Until 1970 penicillins and cephalosporins were the only examples of naturally occurring tJ-Iactam antibiotics. The discovery of 7-a-methoxy cephalosporins (3) from Streptomyces in 1971 stimulated the search for novel tJ-Iactam antibiotics from microbes, both by using sensitive new screening procedures, and by laboratory synthesis.
Erscheinungsdatum: 29.10.2012
备用文件名
lgrsnf/A:\compressed\10.1007%2F978-94-011-2928-2.pdf
备用文件名
nexusstc/The Chemistry of β-Lactams/0c01023e5ff4510c60db6871cc07b83a.pdf
备用文件名
scihub/10.1007/978-94-011-2928-2.pdf
备用文件名
zlib/Biology and other natural sciences/J. E. Baldwin, C. Schofield (auth.), Michael I. Page (eds.)/The Chemistry of β-Lactams_2140084.pdf
备选标题
The Chemistry of [beta]-Lactams
备用出版商
Springer Science + Business Media BV
备用出版商
Springer London, Limited
备用版本
Springer Nature, Dordrecht, 2012
备用版本
Netherlands, Netherlands
备用版本
Dordrecht, 1992
元数据中的注释
sm19272996
元数据中的注释
{"edition":"1","isbns":["9401053006","9401129282","9789401053006","9789401129282"],"last_page":351,"publisher":"Springer Netherlands"}
备用描述
It is over sixty years since Alexander Fleming observed antibiosis between a Penicillium mould and bacterial cultures and gave the name penicillin to the active principle. Although it was proposed in 1943 that penicillin (1) contained a tJ-Iactam ring, this was not generally accepted until an X-ray crystallographic determination of the structure had been completed. RCONH)=r)<o '" (I) 'C0 H 2 Penicillin was the first naturally occurring antibiotic to be characterised and used in clinical medicine. It is now seen as the progenitor of the tJ-Iactam family of antibiotics, which are characterised by the possession of the fourƯ membered tJ-Iactam ring. Chapters in this book will describe how current research has demonstrated that other lactam structures may also show antibacterial activity. Penicillins and cephalosporins (2), the second member of the tJ-Iactam antibiotic family, were both originally discovered in fungi but later detected in streptomycetes. Until 1970 penicillins and cephalosporins were the only examples of naturally occurring tJ-Iactam antibiotics. The discovery of 7-a-methoxyƯ cephalosporins (3) from Streptomyces in 1971 stimulated the search for novel tJ-Iactam antibiotics from microbes, both by using sensitive new screening procedures, and by laboratory synthesis
备用描述
Front Matter....Pages i-xix
1 The biosynthesis of ß-lactams....Pages 1-78
Structure-activity relationships: chemical....Pages 79-100
Structure-activity relationships: biological....Pages 101-128
The mechanisms of reactions of ß-lactams....Pages 129-147
Mode of action: interaction with the penicillin binding proteins....Pages 148-197
ß-Lactamase: mechanism of action....Pages 198-228
ß-Lactamase: inhibition....Pages 229-271
Novel ß-lactam structures — the carbacephems....Pages 272-305
Non-ß-lactam mimics of ß-lactam antibiotics....Pages 306-324
Classical ß-lactam structures....Pages 325-347
Back Matter....Pages 349-351
备用描述
This book provides an authoritative review of developments in the chemistry of Beta-lactams: in particular the synthesis, reactivity and mechanisms of reaction, including novel Beta-lactam structures and non-Beta-lactam analogues
开源日期
2013-08-01
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