Opinion leaders in science and politics examine findings and legislation in alternatives to animal testing!
Refine, reduce, replace - These are the three demands that scientists have placed upon themselves in their search for alternatives to animal testing. Indeed much interdisciplinary research is being carried on today, and new fields have emerged, such as in-vitro toxicology.
The three R's call for new scientific insights. Moreover, validation and acceptance strategies have to be adapted, a process of much ongoing interest and vital concern to the pharmaceutical and cosmetic industries.
Researchers need to know exactly what has been achieved and accepted in alternatives to animal testing in science and politics. In this book they have the opportunity to benefit from the knowledge and expertise of leading researchers and influential representatives of national and international regulatory authorities.
Content:
Chapter 1 Looking Back 33 Years to Russell and Burch: The Development of the Concept of the Three Rs (Alternatives) (pages 1–11): Andrew N. Rowan
Chapter 2 The OECD and International Regulatory Acceptance of the Three Rs (pages 13–19): Hugo M. Van Looy and Herman B. W. M. Koeter
Chapter 3 The European Centre for the Validation of Alternative Methods (ECVAM) (pages 21–25): Erminio Marafante and Michael Balls
Chapter 4 A Timetable for Replacing, Reducing and Refining Animal use with the Help of in Vitro Tests: The Limulus Amebocyte Lysate Test (LAL) as an Example (pages 27–43): Oliver Flint
Chapter 5 The Fund for the Replacement of Animals in Medical Experiments (FRAME): 23 Years of Campaigning for the Three Rs (pages 45–55): Michael Balls and Julia H. Fentem
Chapter 6 Animal Use and Alternatives: Developments in the Netherlands (pages 57–65): L. F. M. van Zutphen
Chapter 7 The RIVM Center for Alternatives to Animal Testing and the Concept of the Three Rs in the Quality Control of Vaccines (pages 67–74): Coenraad F. M. Hendriksen
Chapter 8 ZEBET: Three Years of the National German Center for Documentation and Evaluation of Alternatives to Animal Experiments at the Federal Health Office (BGA) in Berlin (pages 75–84): Horst Spielmann, Barbara Grune?Wolff and Manfred Liebsch
Chapter 9 Reviewed Literature Databank for Alternatives to Animal Experiments – “Gelbe Liste” (pages 85–88): Brigitte Rusche and Ursula G. Sauer
Chapter 10 The SIAT Research, Teaching and Consulting Program in the Area of in Vitro Toxicology. Experimental Research, Screening and Validation (pages 89–98): Christoph A. Reinhardt
Chapter 11 Computer?Aided Drug Design and the Three Rs (pages 99–106): Angelo Vedani
Chapter 12 Computer?Aided Programs in Biomedical Education (pages 107–117): Richard T. Fosse
Chapter 13 Alternatives to Experiments with Animals in Medical Education: A TEMPUS Joint European Project (pages 119–123): Miroslav Cervinka, Zuzana Cervinkova, Michael Balls and Horst Spielmann
Chapter 14 Replacement of Laboratory Animals in the Management of Blood?Sucking Arthropods (pages 125–129): Achim E. Issmer, Thomas H. Schilling, Andreas Vollmer and Jorg Grunewald
Chapter 15 Maintenance of Filarial Cycles in the Laboratory: Approaches to Replacing the Vertebrate Host (pages 131–139): Joachim Rapp, Wolfgang H. Hoffmann, Lisette Keller, Andrea Welzel and Hartwig Schulz?Key
Chapter 16 Improved Drug Metabolizing Capacity of Hepatocytes Co?Cultured with Epithelial Cells and Maintained in a Perifusion System (pages 141–146): Rolf Gebhardt
Chapter 17 Characterization and Use of Long?Term Liver Cultures to Evaluate the Toxicity of Cyclophosphamide or Benzene to Bone Marrow Cultures (pages 147–157): Brian A. Naughton, Benson Sibanda, Julia San Roman and Gail K. Naughton
Chapter 18 European Interlaboratory Evaluation of an in Vitro Ocular Irritation Model (Skin2TM Model ZK1100) Using 18 Chemicals and Formulated Products (pages 159–164): Peter W. Joller, Alain Coquette, Jos Noben, Raffaella Pirovano, Jacqueline A. Southee and Pamela K. Logemann
Chapter 19 Cellular Assays for Testing Peritoneal Dialysis Bags (pages 165–171): Mary Dawson and Zara Jabar
Chapter 20 The Position of the Authorities (pages 173–176): Lavinia Pioda

lgrsnf/A:\compressed\10.1002%2F9783527616053.pdf

nexusstc/Alternatives to Animal Testing: New Ways in the Biomedical Sciences, Trends and Progress/01ec64b63ac606e71ad18e9783479d7c.pdf

zlib/Medicine/Christoph A. Reinhardt/Alternatives to Animal Testing: New Ways in the Biomedical Sciences, Trends and Progress, Second Edition_2149563.pdf

Alternatives to animal testing : new ways in the biomedical sciences, trends and progress [Symposium on Alternatives to Animal Testing, held at the ETH Zurich on the 30th of November in 1992

Alternatives to Animal Testing: New Ways in the Biomedical Sciences, Trends and Progress

Christoph A Reinhardt; Christoph Arnold Reinhardt; Schweizerisches Institut für Alternativen zu Tierversuchen; Symposium on Alternatives to Animal Testing

edited by Christoph A. Reinhardt on behalf of the Swiss Institute for Alternatives to Animal Testing, SIAT

Wiley & Sons, Limited, John

Wiley-VCH Verlag GmbH

VCH; Wiley-Blackwell

Weinheim, New York, Germany, 1994

Weinheim [etc, cop. 1994

Germany, Germany

1, PS, 1994

March 1994

2008

lg995630

{"edition":"1","isbns":["3527300430","3527616055","9783527300433","9783527616053"],"last_page":187,"publisher":"Wiley"}

Includes bibliographical references and index.
Papers from a symposium held at the ETH, Zurich on Nov. 30, 1992, and updated to include developments through fall 1993.

<p>Opinion leaders in science and politics examine findings and legislation in alternatives to animal testing!</p>
<p>Refine, reduce, replace - These are the three demands that scientists have placed upon themselves in their search for alternatives to animal testing. Indeed much interdisciplinary research is being carried on today, and new fields have emerged, such as in-vitro toxicology.</p>
<p>The three R's call for new scientific insights. Moreover, validation and acceptance strategies have to be adapted, a process of much ongoing interest and vital concern to the pharmaceutical and cosmetic industries.</p>
<p>Researchers need to know exactly what has been achieved and accepted in alternatives to animal testing in science and politics. In this book they have the opportunity to benefit from the knowledge and expertise of leading researchers and influential representatives of national and international regulatory authorities.</p>

Can experiments with living animals be replaced? This work offers a survey of alternatives. Recently developed replacement strategies are described in detail from a scientific point of view. The work should be of interest to those engaged in developing or enforcing alternatives to animal testing.

This volume contains the main presentations made at a symposium on alternatives to animal testing held in 1992 and updated to include current developments up to fall 1993 including computer-aided programs

2013-08-01